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The majority of patients with von Willebrand disease (VWD) have a mild bleeding tendency that primarily involves mucosal bleeding. Some patients with the disorder, however, have severe episodes of mucosal or joint bleeding that can hamper daily activities and lead to significant joint impairment. Experience in the setting of severe hemophilia has shown the feasibility and benefits of prophylactic

CONTEXT AND OBJECTIVE: During medical education and training, the values and attitudes of medical students are shaped both by knowledge and by role models. In this study, the aim was to compare the views of first- and final-year students concerning patients with different medical conditions. PARTICIPANTS AND METHOD: In the spring of 1998 all first- and final-year medical students at Göteborg and L

We have studied the degree of genetic variation at a variable Mhc class II beta gene in four populations of Atlantic salmon Salmo salar by using RFLPs. The class II beta gene encodes the part of the Mhc class II molecule that contains the antigen binding region and is therefore essential for disease resistance. There was extensive genetic variation in all four populations; the expected heterozygos

Serious psychopathology in adulthood may be associated with disturbed foetal brain development, which potentially shows lingering “fossil marks” in the cranial and facial regions. Several methods exist for assessing external craniofacial and internal brain distances but, to our knowledge, no method yet provides simultaneous measurement of cranial, facial and brain dimensions in live subjects. In t

Aims: We investigated whether polymorph isms in candidate genes involved in lipid metabolism and type 2 diabetes are related to liver I, at content. Methods: Liver fat content was measured using proton magnetic resonance spectroscopy (H-1-MRS) in 302 Finns, in whom single nucleotide polymorphisms (SNPs) in acyl-CoA synthetase long-chain family member 4 (ACSL4). acliponectin receptors 1 and 2 (ADIP

Human papillomavirus (HPV) persistence is the major cause of cervical cancer, but most HPV infections will not persist and risk factors for HPV persistence are not well known. Chlamydia (C.) trachomatis infection seems to also be associated with cervical cancer. We investigated whether C. trachomatis infection is a risk factor for HPV persistence. In a cohort of 12,527 women participating in a pop

The native bee fauna provides an important ecosystem function, but a large proportion of this fauna in Europe is threatened as a result of habitat loss and fragmentation. The solitary bee Andrena hattorfiana is specialised on collecting pollen from the plant-family Dipsacaceae. In northern Europe the major pollen resource is the insect-pollinated herb Knautia arvensis. We quantified the available

Urban water balances differ from their rural counterparts due to extreme spatial heterogeneity, water imported from outside catchment boundaries and changed flow paths (e.g., drainage pipes and impervious surfaces). Urban catchments are characterized by increased peak discharges and fast response times, each contributing to specific environmental problems. The water balances of towns in the northe

Migrating birds often alternate between flight steps, when distance is covered and energy consumed, and stopover periods, when energy reserves are restored. An alternative strategy is fly-and-forage migration, useful mainly for birds that hunt or locate their prey in flight, and thus, enables birds to combine foraging with covering migration distance. The favourability of this strategy in comparis

This paper reports the findings of a global survey of practice patterns for the management of patients with haemophilia A. A total of 147 haemophilia treatment centres worldwide responded to the questionnaire, supplying data for 16 115 patients with haemophilia A. From these responses, 38% (range: 25-48%) of patients were under 18 years old. Almost half (47%) of patients were reported to have mild

The early marsh orchid, Dactylorhiza incarnata (L.) Soo s. l., grows in medium-rich to rich fens and marshes over much of Europe and parts of Asia. The species is highly polymorphic and different forms may grow together at the same site. In the present study, I tested the hypothesis that these forms represent different migrant populations that have colonized Scandinavia independently of each other

Due to decreased functional capacity as well as high environmental demands there is a risk of diminishing activity outside home in very old age (age 80+). In order to explore differences according to functional limitations (FL) among very old people with respect to frequency of activity, perceived health, overall perception of neighbourhood environment, and perceived problems in the pedestrian env

The gene PTPN22 is located on chromosome 1p13 and encodes a protein tyrosine phosphatase called the lymphoid-specific phosphatase (Lyp). Lyp is expressed in lymphocytes, where it physically associates through its proline-rich motif ( called P1) with the SH3 domain of the protein tyrosine kinase Csk, an important suppressor of the Src family of kinases Lck and Fyn, which mediate TCR signaling. Ther