The estrogen receptor beta (ER beta) is emerging as an important player in the physiology of the endocrine pancreas. We evaluated the role and antidiabetic actions of the ER beta selective agonist WAY200070 as an insulinotropic molecule. We demonstrate that WAY200070 enhances glucose-stimulated insulin secretion both in mouse and human islets. In vivo experiments showed that a single administratio

Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmö Preventive Medicine (n = 5,415) and Malmö Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD

Emerging technologies allow the high-throughput profiling of metabolic status from a blood specimen (metabolomics). We investigated whether metabolite profiles could predict the development of diabetes. Among 2,422 normoglycemic individuals followed for 12 years, 201 developed diabetes. Amino acids, amines and other polar metabolites were profiled in baseline specimens by liquid chromatography-tan

Background-Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood. Methods and Results-To identify pathways associated with cardiometabolic risk, we used liquid chromatography/mass spectrometry to determine the plasma concentrations of 45 distinct met

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by both genetic and environmental factors. Genome scans in families with SLE point to multiple potential chromosomal regions that harbor SLE susceptibility genes, and association studies in different populations have suggested several susceptibility alleles for SLE. Increased production of type I interferon (IFN) an

Objective: To investigate how persons with late effects of polio perceive their participation and problems with participation in life situations and to determine the association between perceived problems with participation and sex, age, marital status, use of mobility aids and access to instrumental support. Design: Cross-sectional. Subjects: A total of 160 persons with prior polio 6-30 months af

This paper will address the effects of mixing low-calorific fuel in to a natural gas fuelled large size combined cycle plant. Three different biofuels are tested namely; air blown gasification gas, indirect gasification gas and digestion gas. Simulations have been performed from 0-100% biofuel natural gas mixtures. The biofuel impacts on the full cycle performance are discussed. Some more in-depth

The impact of different passive protective measures against external vertical fire spread was investigated using the numerical tool Fire Dynamics Simulator (FDS). The numerical study was divided into a validation study and a comparative analysis. The validation study was performed to evaluate FDS as a calculation tool for modelling external vertical fire spread and was conducted using experimental

Under istider, när stora mängder havsvatten var bundet i inlandsisar, var den globala havsnivån lägre än idag och stora delar av kontinentalsockeln torrlagd. Den senaste istiden (cirka 115 000–12 000 år sedan) var inget undantag, då torrlagda områden utvecklades till ekologiskt rika kustområden som möjliggjorde människans spridning över världen. När inlandsisarna smältesteg havsnivån och dessa lanDuring times of lower global sea level, vast areas of the coastal shelf were exposed and converted into ecologically diverse coastal landscapes that wereattractive for human occupation. The landscapes were subsequently flooded during the deglaciation, but well-preserved remains of these landscapes andtheir inhabitants can today be found on the seafloor. In the southern Baltic Basin, where the comp

Glucose-stimulated insulin secretion is biphasic, with a rapid first phase and a slowly developing sustained second phase; both are disturbed in type 2 diabetes (T2D). Biphasic secretion results from vastly different release probabilities of individual insulin granules, but the morphological and molecular basis for this is unclear. Here, we show that human insulin secretion and exocytosis critical

The new estimates of the Maddison Project show that GDP per capita ratio at purchasing power parity (ppp) between Bolivia and Finland has changed from 0.68 ca. 1850 to 0.16 in 2015; similarly, that between Chile and Norway from 0.65 to 0.28. The aim of this article is to present a review of the literature and available quantitative evidence to understand how these extreme differences became possib