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This study is motivated by two research questions: (1) How is an organizational control system established and maintained in product and process innovation? (2) How are innovation processes facilitated or hindered as a result of the interplay between forms of control and autonomy? The thesis investigates these questions by means of an in-depth longitudinal case study involving 15 innovation projec

Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in patient quality of life or symptom burden over the years. In this review, we ask why this might be and explore the pathophysiologica

Stable carbon isotope measurements (δ13C) made on Quaternary sequences of terrestrial plant subfossils are frequently used to infer palaeoclimatic trends. However, differential decomposition of individual constituents during incorporation of plant material into lake sediments could influence these interpretations. Therefore, we investigated down-core variations in the carbon isotope composition (δ

Rationale: Smoking is a primary risk factor for chronic bronchitis, emphysema, and chronic obstructive pulmonary disease, but since not all smokers develop disease, it has been suggested that some individuals may be more susceptible to exogenous factors, such as smoking, and that this susceptibility could be genetically determined. Objectives: The aim of the present study was to assess, in a popul

Adrenaline is a powerful stimulus of glucagon secretion. It acts by activation of β-adrenergic receptors, but the downstream mechanisms have only been partially elucidated. Here, we have examined the effects of adrenaline in mouse and human α-cells by a combination of electrophysiology, imaging of Ca2+ and PKA activity, and hormone release measurements. We found that stimulation of glucagon secret

Thrombocytopenia is common in patients with invasive bacterial infections. Bacteria can activate platelets, but it is unclear if this affects platelet count. The aim of this study was to examine whether bacteraemia with Staphylococcus aureus, which readily activate human platelets, was more likely to be complicated by thrombocytopenia than bacteraemia with Escherichia coli or Streptococcus pneumon

Background: The exact pathophysiological mechanism(s) underlying endolymphatic hydrops (EH) remain elusive. We have previously shown that chronic administration of vasopressin and inhibitors of the cAMP/cGMP degrading enzymes (PDE3, PDE4, PDE5) results in the development of EH to mice. Aims/objectives: Evaluate the ability of spironolactone, an aldosterone antagonist, to prevent EH, when induced b

We live at a time when the Internet is used increasingly for communication, for information, and for the exchange of goods and services. Questions arise about how people with learning disabilities make use of this new technology. In this article, Bjorn Harrysson, with two of his colleagues, A. Svensk and G. I. Johansson, from the Department of Design Sciences at the Lund Institute of Technology in

The recognition of new venture opportunities has been acknowledged as one of the most important abilities of successful entrepreneurs. Explaining the recognition of new venture opportunities has thus become an important element of the scholarly study of entrepreneurship. Building on this stream of research, we present a study of the influence of prior industry and functional work experience on ent

Industrialized production of building components, or entire houses, reduces activities at the construction site to the assembly of parts and has the potential to increase productivity and reduce the design effort invested in every project. However, in order to realize all of the potential efficiency gains that use of predefined components could deliver effective, interoperable information manageme

1. Real Estate Law consists of several subjects: (a) different interests in land, conveyancing, mortgaging, registration, tenancy, easements and other encumbrances and (b) eminent domain, survey law and planning. A more broad definition would perhaps also include subjects such as environmental law and tax law. Most surveyors are educated in domestic law in these areas. This papers proposes a cours