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Type 1 diabetes (T1D) and other autoimmune diseases (AIDs) often co-occur in families. Leveraging data from 58,284 family trios in Finnish nationwide registers (FinRegistry), we identified that, of 50 parental AIDs examined, 15 were associated with an increased T1D risk in offspring. These identified epidemiological associations were further assessed in 470,000 genotyped Finns from the FinnGen stu
In this study of human carotid endarterectomy plaques (using 1128 regions of interest in a total of 10 plaques), we found that photon counting computed tomography (PCCT) can differentiate between attenuation and the spectral patterns of calcium, intra-plaque haemorrhage, thrombus, fibrosis, necrosis and lipid core. This is the first study to show the potential of PCCT in living patients using clin
This article seeks to contribute to understanding the practical “how” of a just climate transition as a systemic change with a focus on the local level. With the backdrop of the central role of municipalities in terms of governance in achieving climate transition while also fulfilling societal functions, it explores cases of eco-social innovations (ESI) of circular practices, with a specific inter
Forest loss, fragmentation, and transformation negatively impact forest biodiversity and ecosystem functionality worldwide. Improving landscape intactness and connectivity through restoration is critical. Determining where to restore remains, however, a challenge. As an approach for prioritizing restoration areas, we define connectivity forest (CFs) as forests outside recognized high conservation
Gastrointestinal (GI) cancers, including esophageal, gastric, pancreatic, liver, and colorectal malignancies, represent a major global health burden due to their high incidence, aggressive nature, and limited treatment outcomes. This review explores the therapeutic potential of carvacrol, a naturally occurring monoterpenoid phenol predominantly found in oregano and other aromatic plants. Carvacrol
The Nordic countries have been described as generous front-runners in their development assistance, making observers suggest the existence of a ‘Nordic Model’. They have been claimed to play a leadership role in a European and global context. Recently, however, this characterisation has been challenged due to changes in Nordic policies and in the external environment. We investigate the developmenThe Nordic countries have been described as generous front-runners in their development assistance, making observers suggest the existence of a ‘Nordic Model’. They have been claimed to play a leadership role in a European and global context. Recently, however, this characterisation has been challenged due to changes in Nordic policies and in the external environment. We investigate the developmen
The Nordic welfare model is known for universalism, egalitarianism, and public responsibility. Integral to this is the “media welfare state”, in which the media supports democratic participation and welfare ideals. Yet globalization, demographic shifts, and digitalization are challenging these foundations, prompting questions about the media’s evolving role. This article explores how Nordic newspa
The endothelin receptor antagonist atrasentan improved kidney outcomes in the SONAR trial for type 2 diabetes and chronic kidney disease (NCT01858532), though individual responses varied. To identify molecular biomarkers of atrasentan response and outcome, we conducted a nested case-control proteomics study (N = 180) within the SONAR trial population and identified urinary clusterin (uCLU) as the
The great tit Parus major is known for its wide range of innovative foraging behaviours, which have enabled adaptation to anthropogenic habitats such as gardens and city parks. Some of the behaviours are general and common whereas others are rare and seem to have been invented and used by single birds. Here we report on a male great tit that specialised in capturing large butterflies that were for
Higher socioeconomic status (SES) is associated with lower mortality. This has been confirmedusing different indicators across several geographical settings. Nevertheless, the mechanismsbehind this association are still under debate. In particular, the timing of the emergence of theSES gradient remains an open question. In this paper, we study the development of SESinequalities in cause-specific m
