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The small leucine-rich proteoglycans fibromodulin and lumican are functionally related extracellular matrix proteins involved in the regulation of collagen fiber formation. Fibromodulin-deficient apolipoprotein E-null mice have decreased vascular retention of lipids and reduced development of atherosclerosis suggesting that fibromodulin may influence the disease process. The aim of the present stu

During the last 15 years questions concerning gender, technology and knowledge, have become increasingly recognized as central to the field of the sociology of technology. Nonetheless, critical questions remain unanswered. These issues are addressed here through investigations of the relationship between gender, work, knowledge and technology. This thesis is composed of an introduction and four in

Polyglandular Autoimmune (PGA) syndrome type II in idiopathic Addison's disease: In a retrospective study of idiopathic Ad-dison's disease (median age at diagnosis 32.5 years, range 8-62; median observation time 17 years, range 0.5-41), 50% met the criteria for PGA syndrome type II. In PGA syndrome type II, 73% had ATD and 41% had IDDM. The full triad was present in 14%. The sequence of appearance

Empirical research on the knowledge dynamics of biotechnology demonstrates a dual local-global knowledge flow pattern. The sector is characterised by strong spatial concentration around nodes of excellence that are interconnected through a global network. This requires a specification of the notion of proximity as a facilitator of learning processes which emphasises its multifaceted configuration.

A competitive tendering process within a public organization does not always render the anticipated results, i.e., the intended strategy is not always realized. This paper shows that the way the strategy process is managed by the parties involved in the tender is of importance to the outcome. Previous research has mainly focused on the situation ex ante the tendering process. This paper contribute

Context: Immune functions seem to have connections to variations in body fat mass. Studies of knockout mice indicate that endogenous interleukin (IL)-1 can suppress mature-onset obesity. Objective: To systematically investigate our hypotheses that single- nucleotide polymorphisms (SNPs) and/or haplotypes variants in the IL-1 gene system are associated with fat mass. Subjects: The Gothenburg osteop

The present article is part of a larger project investigating the various types of linguistic change that affected and might affect the word class traditionally known under the label of interjection. The results of our research, as outlined here, concern the inter-linguistic mobility of units, i.e., borrowings, which in the source language can be (but not necessarily) interjections, and which are

A study of the ambitions of the managers at AB Robertsfors Bruk and their impact on courses of action in the development of wage policy and social arrangements in the community of Robertsfors during the period 1925-35.This study deals with employer actions during a period of both internal and external change to the organization. The main focus is in the areas of wage policy and social arrangements

AIMS/HYPOTHESIS: The aim of this study was to ascertain whether treatment of GAD65 autoantibody (GADA)-positive diabetic patients with alum-formulated recombinant GAD65 (GAD-alum) is safe and does not compromise beta cell function. METHODS: This Phase 2, placebo-controlled, dose-escalation clinical trial, which was randomized through a central office, was performed in 47 GADA-positive type 2 diabe

High-resolution laser-spectroscopy measurements of hyperfine structure and isotope shifts were performed for the 6snd 1 D 2 sequence of Ba-I in the regionn=12–24. Stepwise laser excitations of a collimated atomic beam were used. A strong influence on the hyperfine structure is observed at the perturbation atn=14, caused by interaction with the 5d7d configuration. Whereas the isotope shift for the

The epidemiological evidence for an obesity-cancer association is solid, whereas the association between obesity-associated lipoprotein levels and cancer is less evident. We investigated circulating levels of Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB), LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) and association to risk of overall cancer and common cancer forms. The Malmö Diet and C