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Nya gemensamma nordiska referensintervall inom klinisk kemi. Bättre bas för klinisk bedömning och samarbete

A project engaging the five Nordic countries has presented common reference intervals for the most frequently used biochemical and haematological analytes. The results are based on samples from up to 3000 healthy adult reference persons and are statistically calculated to include 95 % of the reference population’s values. Reference samples were analyzed together with commutable control materials t

Rye bran alkylresorcinols suppress adipocyte lipolysis and hormone-sensitive lipase activity

The effects of alkylresorcinols (ARs) isolated from rye bran on adipocyte lipolysis, hormone-sensitive lipase activity and phosphorylation and on phosphorylation of protein kinase A substrates were studied. Preincubation with ARs for 18 h suppressed catecholamine-stimulated lipolysis in 3T3-L1 adipocytes. Furthermore, phosphorylation of hormone-sensitive lipase (HSL), a key lipase responsible for

Increased aldehyde-modification of collagen type IV in symptomatic plaques - A possible cause of endothelial dysfunction.

Subendothelial LDL-adhesion and its subsequent oxidation are considered as key events in the development of atherosclerotic lesions. During oxidation of LDL, reactive aldehydes such as malondialdehyde (MDA) are formed, which modify apolipoprotein B100. However, the possibility that these reactive aldehydes could leak out of the LDL-particle and modify surrounding extracellular matrix proteins has

Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a six months exercise intervention.

Adipose tissue has an important function in total energy homeostasis and its dysregulation may contribute to life-style related diseases such as type 2 diabetes, cancer and cardiovascular diseases. The aim of this study was to investigate genome-wide mRNA expression in adipose tissue in healthy men before and after an exercise intervention to identify genes or pathways that mediate the beneficial

Soluble Urokinase Plasminogen Activator Receptor is Associated With Inflammation in the Vulnerable Human Atherosclerotic Plaque.

Recently, plasma soluble urokinase plasminogen activator receptor (suPAR) has gained interest as a marker of cardiovascular risk. suPAR is released through the cleavage of urokinase plasminogen activator receptor (uPAR), which is found in monocytes, activated T-lymphocytes and endothelial cells, all involved in atherosclerosis. suPAR levels have been well studied in plasma, but no studies have foc

Elevated flux of cosmic spherules (micrometeorites) in Ordovician rocks of the Durness Group, NW Scotland

Limestone samples from the Cambro-Ordovician Durness Group were crushed, aciddigested and searched for evidence of micrometeorites. Eleven melted micrometeorites were extracted from the magnetic fraction of samples from the Balnakeil and Croisaphuill formations near the top of the group. Other formations in the Durness Group did not yield micrometeorites. Only melted spherules with a distinctive d

Survey of wintering Whooper Swans Cygnus cygnus in January 2015, and habitat shifts 1995 - 2015.

As wintering Whooper Swans Cygnus cygnus have shiftedtheir winter feeding habitats from water to terrestrialones, the International Waterfowl Counts, covering onlycoastal and lake sites since its start in 1967, cannot monitortrue population change. Therefore, special surveyscovering also the terrestrial habitats have been organizedin mainland NW Europe every ive years since 1995. InJanuary 2015, a