Insulin resistance causes compensatory insulin production, which in humans can eventually progress to β-cell failure and type 2 diabetes (T2D). This disease progression involves multi-scale processes, ranging from intracellular signaling to organ and whole-body level regulations, on timescales from minutes to years. T2D progression is commonly studied using overfed and genetically modified rodents

The article maps the pitfalls and affordances of automatic speech recognition in the study of audiovisual media and digital history more broadly. Three key topics are emphasized: first, the collaboration between scholars and audiovisual archives and the potential of automatic speech recognition to transform the way scholars navigate and engage with audiovisual media history; second, what knowledge

Nordic welfare states continue to rely on strong central and local governments in the regulation, funding, and implementation of social policies. However, decentralization of particular policy areas (e.g. activation policies) have further increased the significance of the local level in Nordic social policy regulation. However, increasing differences between local entities (e.g. between urban and

Using electronic health records data and machine learning to guide future decisions needs to address challenges, including 1) long/short-term dependencies and 2) interactions between diseases and interventions. Bidirectional transformers have effectively addressed the first challenge. Here we tackled the latter challenge by masking one source (e.g., ICD10 codes) and training the transformer to pre

Background: Life's Simple 7 (LS7) aims to promote ideal cardiovascular health (CVH). Its association with different cognitive states in the older old is unclear. Objectives: To assess the associations of LS7 with transitions across normal cognition, cognitive impairment, no dementia (CIND), and dementia and evaluate cognitive impairment-free years of life by LS7-defined CVH levels in older adults.

The embedded verb in North Sámi ECM-constructions can appear in one of three different forms: past participle, progressive and infinitive. The existing descriptions of North Sámi say that the past participle places the embedded event before the higher event, that the progressive (traditionally called aktio essive) expresses temporal coincidence with the higher event, and that the infinitive normal

System verification and validation are performed to secure that a system fulfils the different quality aspects, such as reliability, functionality, maintainability, performance and user friendliness. Since the verification and validation activities take a large share of the total project budget, efficiency and effectiveness are key issues. In this paper, a method is presented for application of th

The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Mela

These days, talk of quantum technologies and the coming “quantum revolution” or “quantum leap” is hard to miss. There is a broad agreement that quantum technologies have a high probability of becoming the next disruptive technological development, and the way they should be regulated and the timing of such intervention are issues that are attracting increasing attention. An analysis of how these q

Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study comple

This chapter aims at analysing the inter-organisational networks emerging from interlocking leaders among the most resourceful, national-level civil society organisations (CSOs) in four European countries. By comparing four different country contexts, we analyse differences in the characteristics of networks, find different mechanisms that seem to structure organisational links across the cases, a