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Galectins are small soluble proteins defined by a conserved sequence motif that forms a defining β-galactoside binding site shared among galectins; adjacent binding sites give each galectin a unique fine specificity for a specific subset of galactose containing glycans. A wealth of data now suggests important roles of galectins in both cancer and inflammation. The aim of this project is to get a c
Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic variation in the polymerase genes may affect gene expression or protein configuration and by that cancer risk and clinical outcome. We selected four gen
OBJECTIVE Growth hormone (GH) deficiency is associated with insulin resistance and diabetes. The aim of the current study was to determine incidence of diabetes during GH replacement therapy (GHRT) and the effect of GHRT on fasting plasma glucose concentrations and HbA(1c) in adult patients with GH deficiency. RESEARCH DESIGN AND METHODS-A total of 5,143 GH-deficient patients (male 49.9%; mean age
Background: Previous studies have focused on weight maintenance following weight loss, i.e. secondary weight maintenance (SWM). The long-term results of SWM have been rather modest and it has been suggested that preventing initial weight gain, i.e. primary weight maintenance (PWM), may be more successful. Therefore, developing a prevention strategy focused on PWM, enabling normal weight or overwei
Early diagnosis and reliable prognosis and treatment prediction of breast cancer will ultimately lead to a decreased mortality rate. This can be achieved by identification of prognostic and treatment predictive biomarkers, and by understanding the mechanisms behind early changes in the breast. The cell cycle is a closely controlled process, involving multiple components with regulation on several
Islands are cradles for new biodiversity and provide natural laboratories for the study of population divergence. In my thesis, I investigated the role of different evolutionary processes in the population divergence in the Skyros wall lizard (Podarcis gaigeae), a species where islet populations have strongly diverged morphologies. I used replicate islet populations and their respective most proxi
Pine sawflies (Hymenoptera: Diprionidae) are severe pine defoliators. This thesis investigated sawfly behaviour related to the use of pheromones in integrated pest management, including monitoring with pheromone traps and mating disruption. Neodiprion sertiferr females were placed on pine twigs in the field and 11–30 % of the females that remained on their twig after the first mating re-mated. Onl
With a view to the aetiology and treatment of preterm labour and primary dysmenorrhoea we studied the influence of sexual steroids on the plasma levels of oxytocin and vasopressin, effect of these peptides on uterine contractility in vitro and in vivo, receptor concentrations and antagonists to oxytocin and vasopressin. In postmenopausal women oestrogen increased the concentrations in plasma of bo
Behaviour of male moths and electrophysiological responses of male pheromone-specific olfactory receptor neurones were studied in two model species, the oriental fruit moth Grapholita molesta and the turnip moth Agrotis segetum. The studies were aimed at elucidating the relative importance of different mating disruption mechanisms. In a wind tunnel study of G. molesta, behavioural response to a r
AIM: The aim was to evaluate the results of endovascular aneurysm repair (EVAR) of abdominal aortic aneurysms (AAA) in terms of intra-AAA pressure and clinical outcomes. METHODS AND RESULTS: 0.014-inch guide-wire-mounted tip-pressure sensors were used for direct intra-aneurysm sac pressure measurement (DISP) through translumbar puncture of the AAA. Mean Pressure Index was calculated (MPI) as the p
This report summarises the work undertaken in the CREDIT project and proposals for how to implement the CREDIT framework. It is the final part of the Nordic/Baltic project CREDIT: Construction and Real Estate – Developing Indicators for Transparency. The report presents the objectives and the research model for CREDIT followed by a summary of the results of CREDIT Reports 2, 3, 4 and 5. The conclu
3,100 non-pregnant women and 85 pregnants were miniconized during the 15-year period ending 1994 . The outpatient procedure of minimal conization using a freehand-guided, high power 60W carbon dioxide laser focused to 0.1 mm in spot-size, giving high power density 165,000 W/cm2, produces single-piece tissue specimens for histological examination. The procedure is performed under local anaesthesia
Conditions are presented for when estimated demand systems automatically satisfy adding up. It is shown that there exist nonlinear demand systems (such as the Almost Ideal Demand System) where adding up is allowed in the model, but where it is not automatically satisfied for the LS and SUR estimates. In these situations it is possible to test the applicability of the model as regards adding up. Th
This thesis deals with the fermentation characteristics of lactic acid bacteria (LAB) in oat-based suspensions, with formulation work of fermented products based on oat and with nutritional studies of these products. Changes in structure in terms of viscosity and ropiness were studied when exopolysaccharide (EPS)-producing LAB strains, namely, Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772,
The global company operates from a number of locations worldwide, resulting in implications for the transport, handling and storage of product and parts transported within the company as well as between the company divisions and suppliers and/or consumers. In these companies, the package becomes a frequently used object to complement product features and achieve an effective and efficient means of
