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Dipeptidyl peptidase 4 (DPP-4) inhibitors are now being clinically utilized as glucose-lowering medications for the treatment of type 2 diabetes. Their widespread use and effective glucose-lowering properties have led to great interest in the mechanism of action of this class of drug. Although it has been well accepted that DPP-4 inhibitors lower glucose in part by increasing postprandial insulin
It is commonly believed that the academic sector does not generate enough value for society. This value is often measured in terms of new firms, patents and products, leading to policy responses which aim to enhance ‘commercialisation’ by academics. However, others maintain that academic research generates benefits in many ways, some of which are difficult to measure, and that policy must look bey
Ecosystem degradation and social sustainability have become important issues in the corporate sphere during the last few decades. However, research discussing corporate social responsibility and related concepts has often focused on larger companies, sometimes neglecting the specifics of small and medium-sized enterprises (SMEs). The main purpose of this study is to examine the relationships betwe
Climate change has become one of the main issues in environmental and sustainability discussions during the last decade. Acting to reduce climate change can be viewed as a prosocial behavior, and previous research has found that personal norms are important in explaining these types of behaviors, together with other attitudinal factors. In this study we use Moral Foundations Theory (MFT) to explor
For business and environmental reasons, increased understanding of green consumer behavior is essential. This paper addresses consumer adoption and non-adoption of a high involvement eco-innovation (the alternative fuel vehicle, AFV). The purpose is to integrate two research streams to explore factors driving and hindering adoption. The factors are rooted in environmental psychology research and t
The catastrophic disruption of the L chondrite parent body in the asteroid belt c. 470 Ma initiated a prolonged meteorite bombardment of Earth that started in the Ordovician and continues today. Abundant L chondrite meteorites in Middle Ordovician strata have been interpreted to be the consequence of the asteroid breakup event. Here we report a zircon U-Pb date of 467.50±0.28 Ma from a distinct be
The aim of the article is to explore the location and the meaning given to the rainbow flag in places outside the hegemonic centre. Through three case studies in the global North and South, held together by a multi-ethnographic approach, as well as a certain theoretical tension between the rainbow flag as a boundary object and/or a floating signifier, we seek to study where the flag belongs, to wh
Type 1 diabetes is associated with abberations of fat metabolism before and after the clinical onset of disease. It has been hypothesized that the absence of the effect of insulin in the liver contributes to reduced hepatic fat synthesis. We measured hepatic gene expression and serum metabolites before and after the onset of hyperglycemia in a BioBreeding rat model of type 1 diabetes. Functional p
The pathophysiology of diabetes is complex and recent research put focus on the pancreatic islets of Langerhans and the insulin-secreting beta cells as central in the development of the disease. MicroRNAs (miRNAs), the small non-coding RNAs regulating post-transcriptional gene expression, are significant regulators of beta cell function. One of the most abundant miRNAs in the islets is miR-375. Th
While previous research has advocated the use of online sales channels as a driver for international expansion, the nature of the relationship between e-commerce and international sales is still unexplored. The purpose of this paper is to create a parsimonious model where we investigate whether, and to what extent, strategies pertaining to the geographical scope of international operations moderat
Despite a growing reliance on evolutionary theories when explaining industrial dynamics, the mechanism of selection has received limited attention. Selection is often taken for granted and conceptualised as product market competition. We go beyond this view and distinguish between different types of selection—formal and social—and consider how these lead to different entities being selected. Forma
This contribution analyses the presence of Economic History in the undergraduate study programmes of some European countries. The objective is to offer a counterpoint to the Spanish experience, which will be addressed by other papers and is also likely the most known framework for most of the participants. We look at the total offer of Economic History courses, as well as at whether they are onl
