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Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. Differentiation of both leukemic and normal hematopoietic cells is believed to be intimately coupled to cell cycle
The neutrophil granulocyte contains a number of multifunctional proteins stored in different subsets of granules. The azurophil granules, synthesized early during differentiation, harbour leukocyte elastase, cathepsin G, proteinase 3, and azurocidin; the members of the serprocidin family. In order to study the biosynthesis, processing, and intracellular sorting of the proteins, human cDNA encoding
Trafikverket ansvarar för data om Sveriges vägnät. Vägnätet och dess egenskaper lagras i NVDB, nationell vägdatabas. Trafikverket levererar, tar emot och presenterar stora mängder data och har flertalet avtal med företag och andra myndigheter. Vägdata har ett stort användningsområde innefattande referenssystem för vägnätsanknuten information, planering av drift och underhåll, planering för trafiks
Brottsoffret har sedan det introducerades som ett begrepp på 1970-talet allt mer kommit att dominera den politiska och akademiska debatten kring brott och straff. Mitt syfte med den här uppsatsen är att ur ett kritiskt perspektiv granska den svenska straffrätten ur ett brottsofferperspektiv. Vem är brottsoffret? Det finns ingen övergripande definition av vem brottsoffret är. En fråga som därför u
Unaccompanied children's migration - a study from the perspective of children The aim of the study was to examine unaccompanied children’s migration from their perspective. The questions that were formulated were those about resources and strategies that child migrants use in their everyday lives and the extent to which these resources and strategies can be considered transnational. I also exa
Timber-concrete composite structures were originally developed for upgrading existing timber oors, but during last decades, they have new applications in multistorey buildings. Most of the research performed on these structures has focused on systems in which wet concrete is cast on top of timber beams with mounted connectors. Recently investigations on composite systems were performed at Luleå Un
Uppsatsens syfte är att utreda vilka möjligheter det finns att ingå ett avtal trots parts passivitet. Begreppet passivitet används i betydelsen underlåtenhet att agera när part, under en process till synes syftande till att avtal ska ingås, normalt kan förväntas agera genom en positiv viljeförklaring, ett nekande eller ett förtydligande. Innan passivitetsfrågan behandlas närmare presenteras den The purpose of this essay is to investigate the possibilities of entering into a binding agreement despite the passivity of one of the parties. The term passivity is used to denote the lack of action when a party, during a process with the apparent aim of entering into an agreement, typically can be expected to act through a declaration of intent, a refusal or a clarification. Before a closer en
Energy users who don’t participate in efficiency and conservation programmes despite ongoing outreach are often referred to as ‘Hard-to-Reach’ (HTR). These individuals or organisations can include, e.g., low income or vulnerable households; renters; and small businesses. More effectively engaging HTR audiences is key to ensuring everyone benefits equitably from low-carbon energy transitions and re
Förlust av biologisk mångfald är ett av de största hoten mot ekosystem och derasfunktioner. Nästan 500 arter i den marina miljön i Sverige anses idag vara hotade ellersårbara. En av dessa är Sveriges enda val, tumlaren (Phocoena phocoena), som lever längs hela Sveriges kust och rör sig över stora områden i sin jakt på fisk att äta. Mänsklig påverkan, framför allt genom oavsiktliga bifångster vid gThe harbour porpoise (Phocoena phocoena) is a small toothed whale with a mainly coastal distribution in the northern hemisphere. As a marine top predator, the species can act as an indicator for early warning signs of ecosystem changes. At the same time, harbour porpoises are globally threatened by human activities and in need of conservation. Successful protection of harbour porpoises requires un
This licentiate dissertation emerges at the crossroads of critical disability studies and critical disasterstudies, with a commitment to justice, equality, and accessibility within the realm of disaster risk reduction(DRR). Its purpose was to develop new insights into strengthening crisis preparedness by activelyinvolving and including people with intellectual disabilities, leveraging their own kn
Background: Medical abortion after 12 gestational weeks often requires a stay in hospital. We hypothesised that administering the first misoprostol dose at home could increase day-care procedures as compared with overnight care procedures, shorten inpatient stays, and improve patient satisfaction. Methods: This multicentre, open-label, randomised controlled trial was done at six hospitals in Swede
Introduction: Self-monitoring of blood glucose (SMBG) is the standard of care for women with gestational diabetes mellitus (GDM). This study aimed to review SMBG profiles in women with GDM and to examine how glucose metrics derived from SMBG relate to fetal overgrowth and infants born large for gestational age (LGA, >90th percentile). Material and Methods: This was a single-center, historical, obs
BACKGROUND: Telehealth services are becoming increasingly popular at primary healthcare centres. Some examples include text-based digital triage and health guidance using chats, emails, images and pre-filled forms. Telephone-based communication has until recent years been the predominant means for triage and health guidance, but now includes written communication via computer or smartphone. Hence
Background: Current guidelines for initial management of traumatic brain injury (TBI) support decision making, but they are rarely validated. The Scandinavian guideline for management of children with TBI (SNC16) was developed to minimise the use of cranial computed tomography (cCT) without compromising safety, but the performance of the guideline in a real-world population is unknown. We aimed to
