Sökresultat

In Paper I, 4703 subjects from the Malmö Cost Cancer cohort, with a mean follow-up of 16.5 years, were evaluated for future risk of ischemic stroke in relation to levels of s-LOX1. An increased risk was found for higher level of sLOX-1 OR 1.75 (1.28-2.39), p<0.001, increasing in presence of carotid plaque OR 2.42 (1.71-3.44), p<0.001. Endothelial cells were exposed to oxLDL, resulting in release o

This study examines whether unstructured and structured activities interact in their association with delinquency and cannabis use. We hypothesize that unstructured activities are more strongly associated with delinquency and cannabis use for those who are less engaged in structured activities. Data are drawn from three nationally representative self-report studies conducted between 2005 and 2011

A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [18F]-metafluorobenzylguanidine (mFBG), [68Ga]Ga-DOTA-TOC and [18F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [123I]-metaiodobenzylguanidine (mIBG). The methods

Introduction Neoadjuvant therapy is the standard of care for the treatment of human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC). Studies on first-generation antibody-drug conjugates, such as trastuzumab emtansine (T-DM1), showed equal or slightly lower efficacy than chemotherapy combined with dual HER2 blockade. Trastuzumab deruxtecan (T-DXd) is a next-generation conjugat

Over the past century, Syria and the broader Middle East and North Africa (MENA) region have undergone profound demographic and economic transformations, yet they remain marked by deep regional, ethnic, and gender-based inequalities. These divisions have shaped development trajectories and contributed to social fragmentation, while successive waves of migration carried these dynamics abroad, from

Background: Evidence is limited on whether alterations in diabetes-related health parameters are detectable before clinical diagnosis in novel diabetes subtypes. We investigated trajectories of diabetes-related health parameters in individuals with recently diagnosed type 2 diabetes (T2D). Methods: Using data from the Stockholm Diabetes Prevention Programme cohort (SDPP) participants (n = 215) wit

BACKGROUND AND OBJECTIVE: Prostate cancer (PC) and dementia may commonly co-occur; yet, prior evidence for bidirectional associations is inconsistent. This study aims to determine the associations between PC and dementia in large population-based studies, which may further inform clinical care. METHODS: To assess the dementia risk in men with PC, a national cohort study was conducted in 178 746 me

IMPORTANCE Risk stratification strategies in primary prevention of coronary events lack precision. OBJECTIVE To determine whether prediction of first coronary events is improved by adding information on coronary atherosclerosis from coronary computed tomography angiography (CCTA) to a model using the pooled cohort equation (PCE) risk score tool and the coronary artery calcification score (CACS). D

The textile industry generates vast wastewater containing synthetic dyes and polymeric additives like poly(vinyl alcohol) (PVA), which pose serious environmental challenges. Conventional treatment methods struggle to remove these contaminants while enabling resource recovery. PVA, widely used as a textile sizing agent, increases treatment complexity, while reactive dyes like Reactive Yellow 145 ar

Background: Air pollution has been linked to breast cancer risk, but previous studies have seldom considered specific exposure windows, like pregnancy. During pregnancy the breast undergoes substantial changes and exposures may have a stronger impact than if they occurred during other time periods. This study aims to identify associations between ambient air pollution exposure during pregnancy and

Background: The clinical management of ER-positive/HER2-negative (ERpHER2n) breast cancer is complicated by a heterogeneous patient population, with some patients exhibiting endocrine resistance and an increased risk of recurrence. Among these high-risk subgroups, ERpHER2n Basal-like (ERpHER2n-Basal) breast cancer, as defined by PAM50 gene expression subtyping, remains poorly characterized due to

Aims/hypothesis: The aetiology of type 1 diabetes remains elusive. Family history of type 1 diabetes increases the disease risk but the role of other autoimmune diseases or type 2 diabetes in the family are unclear. Here, we aimed to analyse the effect of family history of diabetes and autoimmune diseases on development of islet autoimmunity and progression to type 1 diabetes. Methods: The Environ

Det råder idag en trend att förtäta, det vill säga bygga tätt i städer istället för att låta städer växa utåt. Det finns många fördelar med att förtäta då en tät stad ger underlag för bättre service och tätare kollektivtrafik vilket därmed kan leda till mer hållbara städer. Men det finns också nackdelar med att bygga tätt. Genom att förtäta städer samlas fler människor på mindre ytor och därmed ocToday it has become a trend to densify cities instead of allowing them to grow outwards. Densification has many advantages, a dense city provides a basis for better service and denser public transport, which can lead to more sustainable cities. However, building dense also has its disadvantages. By densifying cities, more people gather on a smaller area. This result in more children on a smaller a