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Granulopoietic growth factors. Cytokine and cellular regulation of GM-CSF and G-CSF production.

Granulocyte-macrophage- (GM-) and granulocyte- (G-) colony stimulating factor (CSF) are important cytokines in the regulation of hematopoiesis and for the function of mature blood cells. They are also involved in the cytokine network regulating the inflammatory and immune response. The aim of this study was to investigate the regulation of GM- and G-CSF production at the cellular level. The studie

Calcium Responses in the Renal Afferent Arteriole to Angiotensin II and Norepinephrine Stimulation

Studies were performed to investigate the influence of the vasoconstrictors angiotensin II (AII) and norepinephrine (NE) on calcium metabolism in smooth muscle cells of afferent arterioles. Fura-2 and image analysis techniques were used to evaluate calcium responses in the proximal and distal parts of afferent arterioles with attached glomeruli. AII and NE increase intracellular calcium concentrat

On Cholecystokinin and Phospholipase A2 in Insulin Secretion - an Experimental Study With Reference to the Development of Diabetes

In view of unsolved issues regarding cellular events underlying the adaptation of insulin secretion to insulin resistance, together with the observation that insulin secretion induced by the gastrointestinal hormone and neuropeptide cholecystokinin (CCK) is not solely explained by phospholipase C-protein kinase C (PLC-PKC) pathway activation, this study aimed at delineate mechanisms responsible fo

Chronic Obstructive Pulmonary Disease (COPD) Epidemiological and Pan-airway Aspects

Background – Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. However, there is little information on the prevalence and particularly on the incidence of COPD. Also, apart from the importance of tobacco smoking and a1-antitrypsin deficiency, information on contributing risk factors for the development of COPD is limited. Hypotheses – 1. Spi

Mechanisms of transendothelial and tissue transport in the peritoneum. Experimental studies on rat

In the present thesis, the quantitative role of active transport (transcytosis) in bulk transvascular protein movement in vivo was evaluated. Using chemical transcytosis inhibition (N-ethylmaleimide (NEM) and filipin), we were able to show that NEM actually increases endothelial permeability to macromolecules, probably as a result of unspecific toxic action on endothelial cells. Filipin, on the ot

Omställningsberättelser - podcast

Hur gestaltar vi klimatförändringar? Hur pratar vi om mänsklighetens största utmaning någonsin? Vad innebär det att ställa om? Hur vill vi leva när klimatkrisen är över? Vilka är berättelserna och vad gör de med oss?Välkommen till Omställningsberättelser. Här utforskar vi kulturens roll i övergången till en fossilfri värld.Genom vår podcast låter vi konstnärer komma till tals, i samtal med forskar

Caldicellulosiruptor Saccharolyticus: an Ideal Hydrogen Producer?

Popular Abstract in English What is common between the science of physics and global politics? They both define power in terms of energy. Indeed, the uneven distribution of petroleum reserves has been one of the main reasons of social, political and economic problems worldwide. Even more worrying is the rapid increase in the levels of greenhouse gases in the atmosphere. This is mainly caused by ouCaldicellulosiruptor saccharolyticus is an extremely thermophilic, strictly anaerobic, Gram-positive and cellulolytic microorganism with a natural ability to produce hydrogen (H2) at nearly theoretical maximum yield, i.e. 4 mol/ mol of glucose. Due to its CO2-free combustion and high energy density, among other desirable properties, H2is touted as a fuel of the future. Biological H2 production b