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The prevalence of coeliac disease (CD) was initially estimated to 1/1537. Based on serial analysis [GA and endomysial antibodies (EMA)], the prevalence was 6/1970 (0.30%). In autoimmune chronic hepatitis 5.4% and in IDDM 2.6% had CD, why regular screening for CD in these conditions seems motivated. The frequency of IgA-GA positivity was increased in alcoholic liver disease, PBC, primary sclerosin
Treatment options of head and neck squamous cell carcinoma (HNSCC) usually include combinations of radiotherapy and surgery, and in some cases addition of chemotherapy. In locally advanced cases cure rates are low. Current prognostic factors cannot foresee the outcome for the individual patient. There is consequently a need for reliable prognostic and predictive factors. Through identification of
Protein S is a modular protein and a cofactor in the protein C anticoagulant system. It consists of a Gla-module, a thrombin-sensitive loop, four EGF-modules and a SHBG-like module. Protein S has previously been shown to contain four binding sites with high affinities for Ca2+ (Ka>9x105 M-1 at physiological ionic strength) and at least one of the sites h
This thesis examines the cellular and molecular mechanisms involved in the large diversity of the contractile properties in smooth muscle. Six studies, I-VI, are included. I: a slow smooth muscle (aorta) has a different nucleotide and phosphate dependence compared to a fast type (taenia coli). A slow ADP-release can be one mechanism responsible for the lower shortening velocity of aorta. II: treat
The data presented in this thesis deal with the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in adult sensory neurons. We have used different injury and pain models to determine the involvement of PACAP during such conditions. The role of neurotrophins for PACAP expression was also investigated. PACAP is one of the excitatory neuropeptides expressed in small sized DRG ne
The aim of this thesis has been to increase understanding on the process of smoking cessation during pregnancy from the perspective of learning. The smoking pattern before and after pregnancy related to health, Sense of Coherence (SOC) and social issues was studied among all pregnant women in south-east Skåne during the period March 1994 to August 1995. They were asked to fill in a questionnaire d
The G protein-coupled receptors form one of the largest families of proteins involved in signalling between cells. It contains receptors for molecules as diverse as biogenic amines, glycoproteins and enzymes. The manuscripts included in this thesis together describe the initial characterisation of a previously unknown receptor of this class. A DNA fragment was cloned from a mouse genomic library.
Many bacteria express immunoglobulin(Ig)-binding proteins that interact with Ig in a non-immune manner. Several of these Ig-binding bacterial proteins have been well characterized and are widely used as reagents for analysis and purification of Ig's. Protein G found on group C and G streptococci has affinity for constant regions of IgG heavy chains, whereas protein L found on Peptostreptococcus ma
The Wnt-5a gene encodes a secreted protein that regulates several normal processes in embryonic and adult tissues by as yet unknown mechanisms. Expression of Wnt-5a protein does not cause cell transformation, but it instead counteracts the effects induced by transforming Wnts. Inasmuch as Wnt-5a can activate the Wnt/beta-catenin signalling pathway, we performed experiments to determine whether mol
The purpose was to describe ethical aspects on how do-not-resuscitate (DNR) deci-sions are made, established, and communicated between physicians, nurses, patients and relatives. A random sample of 220 physicians and nurses answered a questionnaire about their attitudes to and experiences of the making and communication of a DNR decision. The re-sponse rate was 73%. Twenty seriously ill patients,
Abstract is not available
Pancreatic beta-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes. An early sign of beta-cell dysfunction is impaired nutrient-induced insulin release. Several insulin secretagogues act by increasing the formation of intracellular cAMP. Thus, accurate regulation of cAMP is of vital importance for the ability of the beta-cell to respond properly to these stimuli. The
The coordination and fundamental transformations of organosulfur compounds to polynuclear metal complexes has been studied as models for possible surface species in industrial HDS processes. Reactions between [Os3(CO)11(NCMe)] and various thiols have been studied by UV-Vis, IR and NMR spectroscopy and all experimental findings indicate that the reactions proceed via a two-step consecutive process
According to the three-pore model of peritoneal transport the major exchange pathway between the blood and the peritoneal cavity is represented by “small pores”, permeable to small solutes and water. Osmotically induced fluid flow, as during peritoneal dialysis (PD), is postulated to occur to a great extent through a water-only pathway, whereas proteins are predicted to reach the peritoneal cavity
Invasive candidiasis (IC) is a serious condition and timely diagnosis with early initiation of antifungal therapy is imerative for improving outcomes. Arabinitol is a sugar alcohol with two stereoisomers, D-arabinitol (DA) and L-arabintiol (LA). Several pathogenic Candida species produce DA in vitro and high DA levels have been detected in serum and urine in patients with IC. Renal dysfunction aff
