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Enterostatin is a peptide formed in the stomach and intestine during the activation of pancreatic/gastric procolipase. Procolipase is a necessary cofactor for lipase. These two proteins contribute to the breakdown of dietary triglycerides in the intestine. Enterostatin has been found to act as a satiety factor, selectively inhibiting fat intake both through sites in the gastrointestinal tract and
It is generally assumed that whereas referential nominal phrases are at least of DP size, predicative nominal phrases are structurally smaller. However, this paper argues that at least in Scandinavian, predicative nominal phrases as well as referential nominal phrases can be bigger than, equal to, or smaller than DP. Hence, the only consistent difference between nominal arguments and nominal predi
The growth of environmental consciousness during the recent decades has led to new ethical challenges. Environmental crises have brought to the fore the seldom acknowledged questions of what duties current generations owe towards future generations and what duties human beings owe towards natural entities. A new subdiscipline - environmental ethics - has emerged that especially focuses on these mo
Coagulation factor V (FV) is activated by thrombin through proteolytic cleavage at Arg-709, Arg-1018 and Arg-1545. Upon thrombin activation, the active form of factor V (FVa) is formed. FVa functions as a cofactor to factor Xa in the conversion of prothrombin to thrombin during coagulation. Recently, it was shown that in addition to being a precursor form of the procoagulant FVa, FV functions as a
Natural killer (NK) cells and T lymphocytes are the major effector cells that can recognize and kill tumor cells. NK cells have a constitutive cytotoxic activity and kill a wide spectrum of tumor cells while T cells recognize specific tumor antigens and need to be activated through their TCR to differentiate into cytotoxic T lymphocyte (CTL) killers or T helper cells. Interleukin-2 is the principa
The pathogenesis of inflammatory arthritides include synovial inflammation and joint tissue destruction. Tissue destruction has traditionally been regarded a consequence of inflammation, but recent observations indicate that the processes are not always closely linked and may proceed uncoupled. The ultimate target organs for the destructive process are articular cartilage and bone. This thesis f
The subject of this thesis is the activated protein C (APC)-mediated inactivation of factor Va. The activated form of factor V (FVa) is a procoagulant cofactor for Factor Xa (FXa) in the conversion of prothrombin to thrombin. The procoagulant function of FVa is down regulated by APC through proteolytic cleavage at three sites, Arg306, Arg506 and Arg679. The cleavage at Arg506 is kinetically favore
Declines in the distribution and abundance of many farmland species during recent decades have been attributed to agricultural intensification. Agri-environment schemes are commonly used in Europe to reduce this loss of farmland biodiversity, but their effectiveness may depend on several external factors. In this thesis, I have used one such scheme, organic faming, as a landscape scale experiment
3,100 non-pregnant women and 85 pregnants were miniconized during the 15-year period ending 1994 . The outpatient procedure of minimal conization using a freehand-guided, high power 60W carbon dioxide laser focused to 0.1 mm in spot-size, giving high power density 165,000 W/cm2, produces single-piece tissue specimens for histological examination. The procedure is performed under local anaesthesia
Many ecosystems have historically been disturbed, either naturally or as part of a cultural management. Due to loss of species as a result of too little disturbance, disturbance must be considered as a potential tool for conservation and restoration in various ecosystems. In this thesis work, disturbance effects on a grassland system were studied. The studied grassland had traditionally been sever
The overarching purpose of this thesis was to investigate if different helping effects can be specifically linked to different psychological mechanisms. Helping effects (i.e. the when of helping) refer to situational differences that can increase or decrease the probability of helping. The three helping effects in focus in this thesis, were (1) the identifiable victim effect (the tendency to be
Background: Treatment of primary breast cancer is individualised and adjuvant systemic treatment is delivered to most patients after surgery. Oestrogen receptor (ER) status and progesterone receptor status (PR) can define patients who would benefit from adjuvant endocrine therapy with tamoxifen (TAM) alone or as chemo-endocrine therapy. In spite of adjuvant treatment with TAM, some patients with h
This thesis deals with single-electron tunneling in transistor-like devices in which the central electrode is either a metal nanoparticle (possibly ferromagnetic) or a molecular magnet. The investigated systems split into two different categories, depending on the size of the central island. The smaller islands, such as ultrasmall magnetic metal nanoparticles and Mn12 molecular magnets, are studie
Antennal detection and central nervous integration of behaviourally relevant odours in scarab beetles (Coleoptera: Scarabaeidae) was investigated, using the two Japanese scarabs Anomala cuprea and Phyllopertha diversa (Rutelinae), and the Central African fruit chafer Pachnoda marginata (Cetoniinae) as model species. Electrophysiological single cell recordings in A. cuprea and P. diversa character
The complement system is critically involved in defence against bacterial infection. C2 deficiency is, apart from mannan-binding lectin (MBL) deficiency, the most common homozygous complement deficiency among Caucasians. The classical pathway of complement activation is not functional in C2 deficiency and the condition is associated with invasive infections caused by the encapsulated bacteria Stre
Calcium homeostasis after thyroid surgery was studied during the immediate postoperative period and after one year. One day after hemithyroidectomy ionised calcium decreased whereas basal PTH did not change. EDTA stimulated maximal and total PTH secretion and set-point decreased on postoperative day 1 and normalised on day 7. One year after hemithyroidectomy (n=10) total calcium and 1.25(OH)2D3 de
When a person becomes critically ill, injured and/or undergoes major surgery and requires intensive care, a complex dilemma can arise. The condition of the illness, the specific caring situation and the environment lead to significant changes and effects in the senses and perceptional abilities. Under these conditions some patients can develop symptoms of the Intensive Care Unit syndrome/delirium.
Some aspects on the use of light for tissue characterization and treatment of malignant tumours are discussed within this thesis. The work presented aims at improving optical techniques for tissue characterization, especially to detect malignant and pre-malignant lesions. A knowledge on the interaction between light and tissue is of utmost importance to understand and improve the various technique
