There is currently a dramatic and global increase in obesity, type 2 diabetes (T2D) and associated metabolic disorders. T2D can be delayed or prevented in individuals at risk and identifying and developing new food concepts for the prevention of obesity and T2D is of utmost importance. This thesis describes our work on exploring new food concepts for the prevention of T2D. We have used 3T3-L1 adip

There are many contributing factors to the development of type 2 diabetes, however, failure of beta-cells to sufficiently secrete insulin is the key component. The underlying mechanism of beta-cell failure is not fully established. In this thesis, we examined the role of high glucagon levels, i.e. hyperglucagonemia, for the development of beta-cell dysfunction in pre-diabetic mice. We found that i

Primary Sjögren´s syndrome (primary SS) is a systemic autoimmune rheumatic disease characterized by lymphocytic infiltrations in the exocrine glands leading to classic dryness complaints such as dry eyes and dry mouth. Non-exocrine complaints also occur, e.g. fatigue, myalgia and arthralgia, as well as disturbed mood. The overall purpose of this work was, from a physiotherapeutic perspective, to i

Atherosclerosis is a chronic inflammatory disease characterized by the formation of lipid rich plaques in the arterial wall. Rupture of a plaque results in clinical manifestations such myocardial infarction or stroke. Atherosclerosis is a complex disease where both autoimmune responses towards atherosclerosis-related antigens and smooth muscle repair responses play important roles. This thesis con

Type 2 Diabetes (T2D) is characterized by dysregulated beta-and alpha-cell hormone secretion leading to elevated blood glucose levels. Several proteins are crucial in maintaining exocytosis of the hormone-containing granules such as Syntaxin1A (Stx1A), SNAP25, Munc-18 (Stxbp1) and the family of Synaptotagmins (Syts). The aim of this thesis has been to investigate functional and genetic events that

The Fountain House Movement – or the Clubhouse Movement - is an organization for community support, meeting the needs of adults suffering from mental illness. It was founded by a self-help group among discharged patients in New York in the 1940s. Today there are more than 300 clubhouses around the world. The aim of this dissertation is to characterize, interpret and understand the Clubhouse Moveme

Popular Abstract in English Disasters continue to affect urban populations and housing infrastructure. They are intensified by extreme weather events caused by climate change. This situation has made the creation of synergies between climate change adaptation (CCA) and disaster risk management (DRM) urgent. Despite their similarities and the recognised need to unite CCA and DRM efforts, the fieldsAn increasing number of disasters continue to affect urban populations and housing infrastructure. The overwhelming majority of them have been caused by climate-related events. This situation has made the creation of synergies between climate change adaptation (CCA) and disaster risk management (DRM) urgent. Despite the recognised need to unite CCA and DRM efforts, the fields remain separate. Furt

Popular Abstract in French Certaines recherches ont suggéré une différence entre l’acquisition d’une première langue (L1) et celle d’une langue seconde (L2) à l’âge adulte. L’une des questions débattues dans ce domaine est de savoir quand et pourquoi s’arrête l’acquisition du type L1 et quand commence l’acquisition du type L2 adulte. Dans ce débat, un troisième mode d’acquisition, enfant L2 ou bil

Background: HPV vaccination programs have been introduced in large parts of the world, but monitoring of effectiveness is not routinely performed. Many countries introduced vaccination programs without establishing the baseline of HPV prevalences. We developed and validated methods to estimate protective effectiveness (PE) of vaccination from the post-vaccination data alone using references, which

Do women with Turner karyotype have increased mortality and morbidity in the years after childbirth? No mortality occurred during pregnancy and follow-up in women with Turner karyotype, but a higher rate of circulatory and endocrine diseases and a high risk of aortic aneurysm were confirmed. Pregnancies in women with Turner karyotype are high-risk pregnancies with an increased risk of maternal mor

Besides individual characteristics, people born in the same country may present a related pattern of health status and health care utilisation, perhaps because they share a number of socioeconomic and cultural characteristics in addition to their common geographic origin and language. Rather than using simple ethnical or geographical categories, we apply multilevel regression analysis with individ