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Pathogenic bacteria express a wide array of surface proteins that interact with the environment. Many of these proteins are believed to be important for the virulence. This thesis deals with the binding of immunoglobulins (Ig) and complement regulating proteins to certain bacterial surface proteins. Protein L from Peptostreptococcus magnus binds to Igk-light chains while protein A from Staphylococ
The purpose of the study was to develop an ultrasound (US) protocol for evaluating congenital clubfoot pathoanatomy before and during early treatment. By using 3 easily defined and reproducible US projections the talonavicular and the calcaneocuboid joints were assessed. Normal configurations of the relationships at these joints were obtained by investigating 54 healthy babies at the ages of 0, 4
People can become sensitive to the general structure of different parts of the environment, often without studying that general structure directly, but through being incidentally exposed to instances that conform to the structure. When such learning proceeds unintentionally and gives rise to knowledge that is difficult to verbalize it is often referred to as implicit learning. One of the most comm
Migration of leukocytes from the circulating blood into the extravascular tissue is a key component in inflammatory reactions. Leukocyte extravasation (rolling-activation-adhesion-transmigration) is strictly coordinated by adhesion molecules and chemokines expressed on cell surfaces and in tissues. Tumor necrosis factor-alpha (TNF-alpha) is pleiotrophic cytokine, which plays an important role in t
This work analyses several aspects of multi-conjugate adaptive optics (MCAO) for astronomy. The research ranges from fundamental and technical studies for present-day MCAO projects, to feasibility studies of high-order MCAO instruments for the extremely large telescopes (ELTs) of the future. The first part is an introductory exposition on atmospheric turbulence, adaptive optics (AO) and MCAO, esta
General characteristics and outcome was evaluated in 177 consecutive patients who underwent a major amputation in a defined population. Smoking and diabetes lowered the mean amputation age. Healing failure at six months was seen in 24% of transtibial and in 11% of transfemoral amputees. Preoperative absence of gangrene and hemoglobin >120 g/L increased the risk of healing failure. Six months after
Aims of the study The aims of this study using Gadodiamide injection were to investigate: · Whether Gadodiamide injection was comparable to Gd-DTPA for the enhancement of CNS lesions. · The contrast effect at different field strengths. · The effective time-window for the enhancement of blood-brain barrier damage. · The relations between the concentration of contrast agent and enhancement in p
"Men born in 1914" is a prospective cohort study on the epidemiology of cardiovascular disease. The study is run by the Department of Community Medicine, Lund University, Malmö. Five hundred men participated in the study when it started with a baseline examination in 1982/83. The men were then 68 years old. The psychological part of the study included tests of cognitive function and the serial Col
Immunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offer an alternative to existing brain tumors treatments, which are unable to cure. We have established an experimental, low immunogenic, brain tumor model in the rat. We have increased tumor cell immunogenicity with mutagen treatment or transfection of IFN-g. Mutagen treated glioma cells (tum-) could c
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the HD gene, that leads to dysfunction and death of striatal neurons. The pathogenetic mechanisms underlying HD are not known, but excitotoxicity and dopamine (DA) have been suggested to play a role. In this thesis, the effects of excitotoxicity and DA have been studied in striatal in vit
In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. a set of multigenerational families, in order to locate the loci corresponding to the underlying disease genes or, at least, to narrow down the interesting genome regions. I
Åren 1999–2003 avled drygt 3 000 patienter under intensivvård södra sjukvårdsregionen. I endast 6 procent av fallen (174 patienter) hade man konstaterat total hjärninfarkt med medicinska möjligheter till organdonation. Samtycke till organdonation gavs i drygt hälften av fallen. En motsvarande registrering kan i kvalitetssäkringsprogrammet för intensivvården (PASIVA) bli en rikstäckande kvalitetssä
This dissertation comprises a corpus-based study of the form and function of sentential object complements in Modern Standard Arabic (MSA). The study is motivated by the scarcity of investigations into MSA syntax as opposed to the syntax of Classical Arabic. Complements to three classes of complement-taking predicates (CTPs) manipulation, cognition and utterance are considered. The major part
