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Preterm infants undergo intensive care during a vulnerable period with hemodynamic instability and a rapidly developing and immature CNS. Adequate pain management is essential, since pain experience might lead to acute physiological reactions as well as neurological and neuropsychological sequels. There is no “golden standard” for objective pain assessment, and no evidence-based recommendations fo
The aim of physiotherapy is to promote health and well-being, and to facilitate increased activity and participation of individuals with diseases and injuries. The profession is influenced by different health paradigms which have emerged from different knowledge traditions. The biomedical paradigm of health adopts a dualistic view of mankind in which the normal is regarded as the standard, and the
In this thesis, user friendly and efficient methods for the design of glass structures are developed. The glass structures comprise various boundary conditions. Several types of glass are considered: single layered glass as well as laminated and insulated glass units. Typical load cases for strength design of glass are applied. A recently developed finite element is suggested to be suitable for th
The endothelial glycocalyx is the carbohydrate rich inner layer of the blood vessels. Important components of the glycocalyx are the proteoglycans with their attached glycosaminoglycans. At this location these molecules contribute to the adhesion and transport of leucocytes to inflamed tissue, the anticoagulation as well as the transport of fluid across the vessel wall. All these functions are dis
This dissertation deals with the subject of altars in the churches of the medieval diocese of Lund. The main work on altars in the Catholic church is Joseph Braun´s Der christliche Altar in seiner geschichtlichen Entwicklung (1924). However, despite its extensive content it does not deal with the conditions in Northern Europe. The general aim of this dissertation is to broaden our knowledge about
Shikimic acid production using recombinant E.coli has been developed during the past 15 years due to the increased demand of this product, primarily as a starting material for the anti-influensa medicine Tamiflu?. A detailed metabolic analysis of a shikimic acid producing E.coli strain was made in the current work in order to increase the understanding of shikimic acid production and identify mean
A new energy regime has recently become accessible in collisions at the Large Hadron Collider at CERN. Abundant in hadron collisions, the two-jet final state explores the structure of the constituents of matter and the possible emergence of new forces of nature, in the largest momentum transfer collisions produced. The results from searches for phenomena beyond the Standard Model in the dijet angu
The main scope of this thesis has been to study and develop new purification methods and also to further develop existing methods for purification to enhance their efficacy. Important parameters in the development of the methods are that they should be suitable for scale-up and possible to be integrated into recovery processes. The studies in this thesis describe that a hydrophobic peptide tag ca
In this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. The influence of bioenergetic failure on K+e concentration and Ca2+e homeostasis were also investigated in transient focal ischemia. Moreover, the free radical formati
Background - The effects of intervention can be evaluated in different ways, and objective measurements of changes in lung function are commonly used as the outcome measure. Patient-reported outcome (PRO) is an umbrella term used for all patient-based assessments. One important PRO is health-related quality of life (HRQL), which may be used as an evaluative or discriminative measure. Objectives -
Proteins carry out the instructions encoded in genes and are crucial for many important tasks in the living organism. Often the specific three dimensional structure, or fold, of a protein enables it to carry out a given task. It is an open question whether protein folds have arisen independently or whether mutations to existing protein sequences have caused switches to new folds. In the main part
This thesis deals with different aspects of fatigue crack propagation in IN718. The ultimate objective of the work is to gain understanding of the fatigue process, from the macroscopic stress-strain relations to microscopic fatigue crack growth mechanisms. First, the stress-strain relations, which are fundamental in order to understand what the material encounter, are dealt with. The high temperat
Engagement in daily activities is central for people’s health and well-being. Today, our activity arenas mostly cover great geographical areas, and to reach different activities we must travel. However, people with functional limitations are sometimes restricted in their travelling. In order to investigate accessibility problems in different travel chains, the overarching objective of this thesis
Streptomycetes are Gram-positive bacteria with a complex developmental life cycle. They form spores on specialized cells called aerial hyphae, and this sporulation involves alterations in growth, morphogenesis and cell cycle processes like cell division and chromosome segregation. Understanding the developmental mechanisms that streptomycetes have evolved for regulating for example cell division i
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are omega-3 fatty acids, which have health promoting effects. Since they are highly prone to oxidation, they should be protected, in particular DHA. Several lipids containing DHA were evaluated with respect to the ability of the lipids to protect DHA against peroxidation using an HPLC method developed as part of this research. Furthermore,
Under Indonesia's authoritarian New Order regime of President Suharto, the role envisaged for the small nationalist-Christian coalition the Indonesian Democratic Party (PDI) was that of a pliant state corporatist party, the existence of which was meant to demonstrate the ostensibly democratic character of the regime. From the second half of the 1980s, however, the party began to develop in a criti
An efficient transfer of energy in molecular systems has proven to be of fundamental importance both in nature and industrial applications. The ability of molecules to work together forming collective excitations, so-called excitons, plays a key role in for example the extraordinary fast energy transfer involved in the first steps of photosynthesis. The characterization of excitonic states in conj
Rheumatoid arthritis (RA) is probably the most common source of treatable disability in the Western world. There are several disease-modifying antirheumatic drugs (DMARDs), which have proven to be of therapeutic efficacy in RA, but the lack of a potent, reliable treatment for early RA is a major problem in modern medicine. An obvious line of approach in the quest for better antirheumatic drugs is
Volatile agents are economically and ecologically acceptable only when administered via low-flow systems. However, sevoflurane degrades during low-flow anaesthesia to compound A, and a high carbon dioxide absorber temperature increases this degradation. This thesis suggests that there is a correlation between apparatus dead-space volume and absorber temperature during low- and minimal-flow sevoflu
Most cells are crowded with solutes, enzymes, nucleic acids, structural proteins and membranes. Crowding promotes macromolecular interactions and determines major properties of the cellular environment such as viscosity, diffusion and inhomogeneity. Macromolecular interactions that involve enzymes can affect the kinetic and regulatory properties of these, hence the interactions are part of the met
