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Cardiac fibrosis, associated with a decreased extent of microvasculature and with disruption of normal myocardial structures, results from excessive deposition of extracellular matrix, which is mediated by the recruitment of fibroblasts. The source of these fibroblasts is unclear and specific anti-fibrotic therapies are not currently available. Here we show that cardiac fibrosis is associated with
Promoter methylation is a common phenomenon in tumours, including haematological malignancies. In the present study, we investigated 36 cases of high hyperdiploid (> 50 chromosomes) acute lymphoblastic leukaemia (ALL) with methylation-specific multiplex ligase-dependent probe amplification to determine the extent of aberrant methylation in this subgroup. The analysis, which comprised the promoters
OBJECTIVE-We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study. RESEARCH DESIGN AND METHODS-Complete eight-locus HLA genotyping data were generated. Expected patient class I (HLA-A, -B, and -C) allele frequencies were cal
The World Health Organization (WHO) classification of myeloid leukaemia was revised in 2008. It incorporates newly recognized entities and emphasizes the pivotal role of cytogenetic abnormalities. The aim of this study was to evaluate the usability of the WHO classification when applied to a large population-based paediatric acute myeloid leukaemia (AML) cohort. We included children diagnosed with
OBJECTIVE: This study utilized the evidence-gap map method and critically examined the scope, methodologies, and focus of the studies that investigated the influence of the built environment on inpatient healthcare settings over a decade (2010-2021).METHODS: We conducted a systematic review per the preferred reporting items for systematic reviews and meta-analyses guidelines and surveyed 406 artic
Mars science fiction (SF) has interacted with Mars science ever since the advent of modern science, and has largely influenced public perceptions of the red planet and its exploration. In this chapter, it is argued that it has not only shaped numerous (mis)conceptions about the possibilities of indigenous Martian life, eventual human settlement and its challenges, but that it also has a large outr
Subjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep problems with changes in brain and behaviour. This study aimed to investigate whether subjective reports of sleep problems in HD are associated with brain volume, neurocognitive decline, and neuropsychiatric symptoms. This retros
Obesity is a major threat to global health and metabolically associated with glycerol homeostasis. Here we demonstrate that in human adipocytes, the decreased pH observed during lipolysis (fat burning) correlates with increased glycerol release and stimulation of aquaglyceroporin AQP10. The crystal structure of human AQP10 determined at 2.3 Å resolution unveils the molecular basis for pH modulatio
Chronic obstructive pulmonary disease (COPD) is a leading cause of death world-wide. Recently, we showed that COPD is associated with gene polymorphisms in SUMF1, a master regulator of sulfatases. Sulfatases are involved in extracellular matrix remodeling and activated by SUMF1, but their role in the lung is poorly described. We aimed to examine how sulfatases are affected in the airways of patien
Popular Abstract in Danish Omkring halvdelen af den globale kulstof mængde som findes i jorden, er lagret i de arktiske jorde. Arktiske jorde har været anset for at være vigtige kulstof reservoirs de sidste 10.000 år, hvor der bliver optaget mere kulstof end der frigives. Dette skyldes blandt andet den langsomme omsætning af organiske materiale på grund af de kolde forhold, men også de store mængdArctic ecosystems hold massive amounts of the global carbon in their soils and are of great importance for the global terrestrial exchange of greenhouse gases to the atmosphere. The arctic region has in general been acting as a C sink for the past 10000 years, however with climate change the C balance in some areas is shifting towards becoming a C source. Herbivory are an important part of many ec
Glacial-interglacial variations in CO 2 and methane in polar ice cores have been attributed, in part, to changes in global wetland extent, but the wetland distribution before the Last Glacial Maximum (LGM, 21 ka to 18 ka) remains virtually unknown. We present a study of global peatland extent and carbon (C) stocks through the last glacial cycle (130 ka to present) using a newly compiled database
Diabetes is a bihormonal disorder resulting from combined insulin and glucagon secretion defects. Mice lacking fumarase (Fh1) in their β cells (Fh1βKO mice) develop progressive hyperglycemia and dysregulated glucagon secretion similar to that seen in diabetic patients (too much at high glucose and too little at low glucose). The glucagon secretion defects are corrected by low concentrations of tol
Aquaglyceroporins are channels that facilitate the flux of glycerol and water across lipid bilayers. Although structural information is available for several aquaglyceroporins, the details of how water and glycerol selectivity are maintained and how protons are excluded remain elusive. An approach to obtaining data on the hydrogen atom positions is to apply neutron macromolecular crystallography.
“Wear a Dress, Keep Clean, Keep Your Legs Together” - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Ev
https://rwi.lu.se/2017/09/29/wear-dress-keep-clean-keep-legs-together/ - 2025-07-06
1 Utbildningsplan 1. IDENTIFIKATION • Programmets namn och inriktning: musikerutbildning, symfoniorkesterinstrument. • Omfattning i högskolepoäng: 180. • Nivå: G. • Programkod: KGMUS. Inriktning: SYMF. • Utbildningsplanen är beslutad i Konstnärliga fakultetsstyrelsen den 11 augusti 2008. Utbild ningsplanen träder i kraft den 11 augusti 2008. 2. PROGRAMBESKRIVNING Musikerutbildning, symfoniorkeste
https://www.mhm.lu.se/en/sites/mhm.lu.se.en/files/kgmus_symf_sve_uppdaterad.pdf - 2025-07-06
1 Utbildningsplan 1. IDENTIFIKATION • Programmets namn och inriktning: musikerutbildning, sång. • Omfattning i högskolepoäng: 180. • Nivå: G. • Programkod: KGMUS. Inriktning: SÅNG. • Utbildningsplanen är beslutad i Konstnärliga fakultetsstyrelsen den 11 augusti 2008. Utbild ningsplanen träder i kraft den 11 augusti 2008. 2. PROGRAMBESKRIVNING Musikerutbildning, sång, syftar till att utbilda musik
https://www.mhm.lu.se/sites/mhm.lu.se/files/kgmus_sang_sve.pdf - 2025-07-06
1 Utbildningsplan 1. IDENTIFIKATION • Programmets namn och inriktning: musikerutbildning, symfoniorkesterinstrument. • Omfattning i högskolepoäng: 180. • Nivå: G. • Programkod: KGMUS. Inriktning: SYMF. • Utbildningsplanen är beslutad i Konstnärliga fakultetsstyrelsen den 11 augusti 2008. Utbild ningsplanen träder i kraft den 11 augusti 2008. 2. PROGRAMBESKRIVNING Musikerutbildning, symfoniorkeste
https://www.mhm.lu.se/sites/mhm.lu.se/files/kgmus_symf_sve.pdf - 2025-07-06
– 26 – Utbildningsplan 1 Identifikation • Programmets namn och inriktning: musikerutbildning, symfoniorkesterinstrument. • Omfattning i högskolepoäng: 180. • Nivå: G. • Programkod: KGMUS. Inriktning: SYMF. • Utbildningsplanen är beslutad i Konstnärliga fakultetsstyrelsen den 11 augusti 2008. Utbild ningsplanen träder i kraft den 11 augusti 2008. 2 Programbeskrivning Musikerutbildning, symfoniorke
https://www.mhm.lu.se/sites/mhm.lu.se/files/utbildnings_utbplan_kandidat_symf.pdf - 2025-07-06
https://www.jur.lu.se/utbildning/studievagledning - 2025-07-05
Doktorandkurs vid Institutionen för informatik Kursöversikten nedan är skriven på engelska.Course overviewThe course focuses on different traditions, concepts, perspectives, and applications within the field of Philosophy of Technology (PoT). You will explore analytical, phenomenological, and critical approaches, and learn about key philosophers and ideas in relation to the essence of technology.
