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Importance: Trastuzumab emtansine (T-DM1) is presently approved for treatment of advanced breast cancer and after incomplete response to neoadjuvant therapy, but the potential of T-DM1 as monotherapy is so far unknown. Objective: To assess pathologic complete response (pCR) to standard neoadjuvant therapy of combination docetaxel, trastuzumab, and pertuzumab (DTP) vs T-DM1 monotherapy in patients
In this work, we present the misspecified Gaussian Cramér-Rao lower bound for the parameters of a harmonic signal, or pitch, when signal measurements are collected from an almost, but not quite, harmonic model. For the asymptotic case of large sample sizes, we present a closed-form expression for the bound corresponding to the pseduo-true fundamental frequency. Using simulation studies, it is show
Novel biomarkers are key to addressing the ongoing pandemic of type 2 diabetes mellitus. While new technologies have improved the potential of identifying such biomarkers, at the same time there is an increasing need for informed prioritization to ensure efficient downstream verification. We have built BALDR, an automated pipeline for biomarker comparison and prioritization in the context of diabe
MEMORANDUM OF UNDERSTANDING MEMORANDUM OF UNDERSTANDING BETWEEN THE EUROPEAN COMMISSION AND THE LEAGUE OF EUROPEAN RESEARCH UNIVERSITIES Page 1 of 5 MEMORANDUM OF UNDERSTANDING BETWEEN THE EUROPEAN COMMISSION AND THE LEAGUE OF EUROPEAN RESEARCH UNIVERSITIES The European Commission, hereinafter referred to as `the Commission´, and the League of European Research Universities, the headquarters of wh
https://www.lu.se/sites/www.lu.se/files/era_final_mou_leru.pdf - 2026-07-15
LUDC-IRC Postdoctoral Program 2020 – Project 3 LUDC-IRC Postdoctoral Program 2020 – Project 3 Role of intracellular C3 in homeostatic autophagy and survival in pancreatic β-cells PI: Anna Blom Co-PI: Erik Renström Purpose and aims To investigate the function of intracellular C3 within pancreatic β-cells, in cytoprotective autophagy. • Firstly, to investigate blood glucose homeostasis in a new nove
https://www.ludc.lu.se/sites/ludc.lu.se/files/blom_project_3.pdf - 2026-07-15
Denna uppsats behandlar den svenska lagen (2023:560) om granskning av utländska direktinvesteringar (UDI-lagen) och dess definition av begreppet portföljinvestering. Särskilt analyseras lagens anmälningsskyldighet för portföljinvesteringar som motsvarar eller överstiger ett innehav om tio procent och hur denna reglering förhåller sig till den fria rörligheten för kapital enligt arti-kel 63 FEUF. UThis thesis examines the Swedish Act (2023:560) on the Screening of Foreign Direct Investments (the FDI Act) and its definition of the concept of portfolio investments in relation to the corresponding definition of portfolio investments under EU law. The thesis specifically analyzes the scope of the Act’s notification requirement as it applies to portfolio investments corresponding to or exceeding
The purpose of this study is to highlight the interaction in the press between the indigenous people -the Orang Ulu- in Sarawak state, Borneo, and the Malaysian government. The focus lies on the Kayan tribe in the Uma Juman settlement, and how the government controlled media and lack of an open two-way dialogue affects them. A people without freedom of speech are a people in permanent danger of ab
This paper introduces a new substrate for reverse-phase protein microarray applications based on macroporous silicon. A key feature of the microarray substrate is the vastly surface enlarging properties of the porous silicon, which simultaneously offers highly confined microarray spots. The proof of principle of the reverse array concept was demonstrated in the detection of different levels of cyc
Objective A common threonine481serine polymorphism (T481S) has been shown in vitro to strongly activate the chloride channel Kb (CLC-Kb) expressed in the kidney, and the 481S allele has been associated with human hypertension. The study aim was to evaluate the association of the T481 S polymorphism with blood pressure (BP) levels and the BP progression rate in Swedes. Design and methods The cardio
”Residents are refusing to pay until an effort is made to clean up, while authorities are refusing to remove refuse until residents pay”. This is the front-page headline of a prominent morning newspaper in Cape Town, South Africa that strikes to the core of what this research seeks to explore. For somewhere between this deadlock lurks a social phenomenon, the “culture of non-payment” borne as a re
Prostate cancer is the most common malignancy of men in Western countries. Patients with advanced prostate cancer suffer from incurable bone metastases. Recent data indicate that interactions between prostate cancer cells, osteoblasts, osteoclasts and the bone matrix are essential in the formation of bone metastases. FGF-8 is widely overexpressed in prostate cancer. Recently, FGF-8 has been found
Future wireless systems envision higher speeds and more reliable services but at the same time face challenges in terms of bandwidth being a limited resource. Two promising techniques that can provide an increased throughput without requiring additional bandwidth allocation are multiple-input multiple-output (MIMO) systems and ultra-wideband (UWB) systems. However, the performance of such systems
Based on toxicological evidence, human exposure to phthalates (PHs) and diisononylcyclohexane-1,2-dicarboxylate (DINCH) may contribute to adverse health effects, especially during vulnerable developmental stages. To support the exposure assessment for this group of endocrine disruptors, we developed and validated a method for the analysis of 14 PH and 3 DINCH metabolites in human urine and materna
Why join the union? | Sveriges akademikers centralorganisation Hoppa till huvudinnehåll About Saco Our issues Join a union Contact Employees About saco.se How we process your personal data Cookies and pixels Saco Student Fairs For exhibitors Sweden: A strong market for international recruitment Rates & stand solutions Book your stand FAQ for exhibitors Opinion & facts International activities Saco
https://www.saco.se/en/worklife/why-join-the-union/ - 2026-07-11
Methylation of the cytosine bases in CpG dinucleotides of DNA is important in many cellular functions including gene regulation, chromosome inactivation, as well as in cancer and other diseases. In this report we investigate the structural effects of methylation of cytosines in CpG sites. Hereditary diseases are frequently caused by mutations in CpG dinucleotides. Aqueous solution molecular dynami
This Master's thesis project aims to explore the possibility of a mixed simulation environment in which parts of a software model for emulating a hardware design may be swapped with their corresponding RTL description. More specifically, this work focuses on the sofware model for Arm's next-generation Mali GPU, which is used to understand system on chip properties, including functionality
This thesis is about the intersection between Corporate Social Responsibility and Supply Chain Management. I call this upstream CSR, the phenomenon that arises when an issue on a company’s CSR agenda becomes an issue for its sourcing and supply management operations. Upstream CSR as a phenomenon is not without controversies, but it also holds an important potential for reducing negative environm
Estimating the change in groundwater recharge from an introduced artificial recharge system is important in order to evaluate future water availability. This paper presents an inverse modeling approach to quantify the recharge contribution from both an ephemeral river channel and an introduced artificial recharge system based on floodwater spreading in arid Iran. The study used the MODFLOW-2000 to
Arthritides are musculoskeletal diseases, which predominantly affect the joints e.g. osteoarthritis (OA) and rheumatoid arthritis (RA). Modern treatment strategies include early detection and careful monitoring of the disease course. Close monitoring is also the basis for individualized treatment. Monitoring should be done using methods reflecting different aspects of the disease to get a broad pe
Building owners are encouraged to reduce energy use in order to both contribute to national energy-saving goals and reduce the costs of heating and operation. It is important to choose the most optimal renovation measures available so as to achieve cost-effective energy use while maintaining excellent indoor environments, without sacrificing architectural quality or negatively affecting the enviro
