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När ett barn föds är det mycket i samhället som det ännu inte har träffat på. Ja, faktiskt det mesta. Vem barnet blir och vilka vägar det väljer genom livet kommer att påverkas av många faktorer, däribland utformningen av alla de produkter och miljöer det över tid möter och interagerar med. I detta kapitel ägnar vi oss åt fysiska aspekter av interaktionen mellan individ och samhälle, med fokus på
Wooden multi-story buildings have increased their market share in Europe over the last decades, mainly due to their relatively small carbon footprint and rapid onsite construction. Compared to more conventional heavy concrete buildings, wooden buildings are more sensitive to dynamic loads at low frequencies. Moreover, the dynamic response is generally more difficult to predict. This is, for exampl
The use of wood as load-bearing material in residential and office buildings has increased significantly in Europe over the last decades. Such buildings often have wooden floors built with boards supported by joists and/or beams. The modal properties of such floors are important regarding the floors’ dynamic response to walking and other usage as well as structure-borne vibration and re-radiated n
The digitalization of the process for building permit (involving the use of 3D information systems) is seen as a priority in a wide part of the world. Since it is a very multidisciplinary use case, involving a variety of stakeholders tackling complex issues and topics, some of them joined their efforts and skills in the European Network for Digital Building Permit. The initial activity of the netw
This paper addresses the quantification of the value of damage detection system and algorithm information on the basis of Value of Information (VoI) analysis to enhance the benefit of damage detection information by providing the basis for its optimization before it is performed and implemented. The approach of the quantification the value of damage detection information builds upon the Bayesian d
Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect association with an ATM L2307F (rs56009889) mutation in adenocarcinoma for discovery (adjusted Odds Ratio = 8.82, P = 1.18 × 10−15) and replication (adjusted OR = 2.93, P = 2
In this study we used a large previously built database of 2,892 mammograms and 31,650 single mammogram radiologists' assessments to simulate the impact of replacing one radiologist by an AI system in a double reading setting. The double human reading scenario and the double hybrid reading scenario (second reader replaced by an AI system) were simulated via bootstrapping using different combinatio
Co-feeding of renewable feedstocks in general, and lignin streams in particular, in petroleum refineries is an attractive means of increasing the proportion of renewable fuel. Four separate units in an integrated refinery can be envisioned using lignin as a feedstock: the hydrotreater, the fluidised catalytic cracker, the hydrocracker and the slurry hydrotreater. A conceptual process design study,
With the construction sector being responsible for about 40% of the energy and material use, the sector has a great responsibility for lowering the consumption if we are to succeed in our global pursuit for the green transition. However, buildings must still comply with the demands of users. For long-span, openspace lightweight, multi-storey buildings, this provides a potential risk related to ann
As part of the green transition, a current trend in the construction sector is to utilize more wood and lightweight composites, aiming at a reduction of the embodied energy in buildings. At the same time, with a focus on circularity and reuse, large-span structures are preferable, since they provide more flexibility for future uses of the building. The mix of large spans and lightweight structures
Timber buildings are intrinsically lightweight and hence can be susceptible to low-frequency vibrations and structure-borne noise. So, within the development of technical solutions for mitigating unwanted vibrations and noise, accurate and computationally efficient numerical models are considered to be of great value. Such models should take into account all physical phenomena that are relevant fo
Tissue clearing allows 3D-imaging of large biomedical samples, but can be affected by blur effects limiting individual cells detection. Using a structured illumination light sheet we solve this issue, obtaining high-contrast images in turbid samples.
CONTEXT: The I148M (rs738409-G) variant in PNPLA3 increases liver fat content but may be protective against cardiovascular disease. Insulin resistance (IR) amplifies the effect of PNPLA3-I148M on liver fat. OBJECTIVE: To study whether PNPLA3-I148M confers an antihyperlipidemic effect in insulin-resistant patients. DESIGN: Cross-sectional study comparing the impact of PNPLA3-I148M on plasma lipids
At DESY the Synchrotron Light Source PETRA III offers scientists outstanding opportunities for experiments with hard X-rays of exceptionally high brilliance since 2009. Research activities have been started towards a future upgrade scenario of PETRA III which envisions the conversion of the PETRA ring into a ultra-low emittance hard X-ray radiation source: PETRA IV. The lattice design is aiming fo
Recombinant antibody libraries can provide a source of renewable and high-performing binders tailored for use in affinity proteomics. In this context, the process of generating site-specific 1:1 tagging/functionalization and/or orientated surface immobilization of antibodies has, however, proved to be challenging. Hence, novel ways of generating such engineered antibodies for use in affinity prote
Computer-based design analysis is nowadays of utmost importance for most engineering design projects. However, this brings some challenges, among them that of the collaboration between engineering designers and design analysts. Since they work with, and are responsible for, different areas, they do not necessarily have full insight into each other’s way of working. The issue of integration between
Objective: To review the literature on progress regarding (1) effectiveness of vaccines for prevention of otitis media (OM) and (2) development of vaccine antigens for OM bacterial and viral pathogens. Data Sources: PubMed database of the National Library of Science. Review Methods: We performed literature searches in PubMed for OM pathogens and candidate vaccine antigens, and we restricted the se
Aims Postural tachycardia syndrome (POTS), a common and debilitating cardiovascular disorder, is characterized by an exaggerated heart rate increase during orthostasis and a wide spectrum of adrenergic-related symptoms. To determine the aetiology of POTS, we examined a possible pathophysiological role for autoantibodies against α1-adrenergic (α1AR) and β1/2-adrenergic receptors (β1/2AR). Methods a
