In FDCP2 myeloid cells, IL-4 activated cyclic nucleotide phosphodiesterases PDE3 and PDE4, whereas IL-3, granulocyte-macrophage CSF (GM-CSF), and phorbol ester (PMA) selectively activated PDE4. IL-4 (not IL-3 or GM-CSF) induced tyrosine phosphorylation of insulin-receptor substrate-2 (IRS-2) and its association with phosphatidylinositol 3-kinase (PI3-K). TNF-alpha, AG-490 (Janus kinase inhibitor),

Introduction: Cyclic adenosine 3’5’-monophosphate (cAMP) and cyclic guanosine 3’5’-monophoshpate (cGMP) are critical intracellular second-messengers involved in the transduction of a wide variety of extracellular stimuli, including peptide hormones, growth factors, cytokines, neurotransmitters and light. These messengers modulate many fundamental biological processes, including growth, differentia

Popular Abstract in Swedish Under de senaste decennierna har innemiljön och dess relation till hälsa rönt ett allt större intresse. En viktig aspekt i detta sammanhang har varit kopplingen mellan fukt i byggnader och hälsa. Cementbaserade material innehåller ofta överskottsvatten ("byggfukt") när de gjuts då detta är nödvändigt för deras arbetbarhet och flytegenskaper. Förutom det höga vatteninnIn recent decades there has been an increasing interest in the indoor environment and its connections with public health. One important topic discussed has been the relation between the moisture in buildings and health. Cementitious materials, when cast, contain excess water since this is necessary for workability and for flow properties. The pore solutions in cementitious materials, besides bei

Current views on the mechanism of the formation of nodular graphite in cast iron are examined with respect to their explanatory power. The aim of this review is to find, if possible, a rationale for further studies. Arguments are presented in favour of a comprehensive model, encompassing the characteristics of both the nucleation and the growth of the graphite. A plea is made for focusing on the m

Elongation factor Ts (EF-Ts) is the guanine nucleotide-exchange factor for elongation factor Tu (EF-Tu) that is responsible for promoting the binding of aminoacyl-tRNA to the mRNA-programmed ribosome. The structure of the Escherichia coli EF-Tu-EF-Ts complex reveals a protruding antiparallel coiled-coil motif in EF-Ts, which is responsible for the dimerization of EF-Ts in the crystal. In this stud

This article describes a PIXE system designed and constructed for routine longitudinal scanning of single hair strands. In constructing a PIXE system for trace elemental scans of single hair strands on a routine basis, a fairly intense beam has to be used but the heating damage must be kept to a minimum. The experimental conditions (charge integration, beam homogeneity etc.) have to be carefully c

In the Prince Charles Mountains (PCMs) the conformable Permian-Triassic (P-T) succession is characterised by an abrupt transition from coal-bearing to coal-lacking strata, which coincides with the demise of the Permian Glossopteris-dominated flora. About 32% of the typical Permian spores and pollen are registered for the last time in the uppermost coal. Throughout the earliest Triassic an addition

Popular Abstract in EnglishStudies of an organizational intervention on staff turnover and fatigue in the staff and Changes in goal-attainment in the patientgroup.Quasi-experimental study with Three different phases (Before), under and after the intervention.Quasi-experimental study of effects of an organizational intervention on staff and patients over a 8 year perspective; Before, under and after an organizational change. Effects on staff are staff-turnover, fatigue and burnout (n=268) on Three wards including the intervention ward. Independent variables are staff demographics, education, experience, job status, sick-leave and responses on a burn-ou

Popular Abstract in Swedish Det övergripande syftet för denna avhandling är att bidra till utvecklingen av en teori om förändringsarbete och lärande i arbetslivet. De specifika förändringsprocesser som studerades skedde inom ramen för en interaktiv förändringsansats som syftade till en emancipatorisk utveckling: att de anställda skulle få ökat inflytande över sin arbetssituation, vilket i sin tur The general aim of the investigation is to contribute to the development of a theory of change and learning within the working environment. The specific change processes that were examined, emerged from an interactive initiative for change, intending to facilitate an emancipatory development: employees increasing their control of the work situation, thus improving the quality of service. The empir

For the extrapolation of data obtained from experimental animals to the human situation, it is important to know the similarities and differences between human and animal species. Some important characteristics of nitric oxide synthase (NOS) in myometrium and vagina from human and rat were compared. NOS-activity was measured by the formation of 14C-citrulline from 14C-arginine and the expression o

Hur ska den svenska samhällsstrukturen vara utformad? Vem ska egentligen göra vad? Detta är centrala frågor som idag diskuteras flitigt när man både på nationell och lokal nivå konstaterar att det är gott om framtida utmaningar. Delvis råder det nu en situation där 'hela havet stormar' när den befintliga samhällsstrukturen är under utredning genom t ex Ansvarskommittén. Inom avfallsområdet har eme

The bismuth-stabilized (2 x 4)-reconstructed InP(100) surface [Bi/InP(100)(2 x 4)] has been studied by synchrotron-radiation core-level photoelectron spectroscopy. The spectra are compared with previous core-level data obtained on a clean InP(100)(2 x 4) surface. The findings support that the P 2p surface-core-level shift (SCLS) of the clean InP(100)(2 x 4), which has higher kinetic energy than th

This article attempts to show how the concept of the body - as it has been applied in feminist thought - can be utilised in trying to understand the changing and at times problematic working relations between doctors and nurses in Sweden. Three approaches are applied with respect to the body: (1) Doctors and nurses belong to two different collective bodies which embody historical constructions of

Photosynthesis in light which is so weak that excitation rates are comparable to the decay rates of S-states is modelled. It is found that oxygen evolution rate varies in a non-linear way with Photosystem II excitation rate in this region, but asymptotically approaches a linear relationship (with a slope of one oxygen molecule per four excitations) as excitation rate increases. The asymptote gives

BACKGROUND: Human exposure to persistent organic pollutants (POPs) is ubiquitous and found in all individuals. Studies have documented endocrine disrupting effects and impact on reproduction. The aim of the present study was to compare the level of xenoestrogenic activity in serum of groups with varying POP exposure, and to evaluate correlations to the POP biomarkers, 2,2',4,4',5,5'-hexachlorobiph