Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. Serotonin (5-HT) signaling via the 5-HT 2B receptor has been recognized as a promising preclinical target for fibrosis. Despite this, the involvement of the

Accurate communication of the severity of violence in intimate relations is essential for the appropriate evaluation of offenders and victims in contexts such as court trials, custody cases, and the continuation of relationships. Using a new paradigm, this study quantifies discrepancies in how the severity of violence is communicated in texts written by offenders, victims, and bystanders who witne

Previous research of gender differences in power has largely focused on the public domain (e.g., leadership positions), and to a lesser extent power on the private domain (e.g., power in private relationships), where people may perceive these domains to be more or less important in their lives. We studied gender differences in preference weighted power (PWP) in different domains by weighting the p

In Sweden, a sustainability index (SI) has been used since 2014 as an internal benchmark management tool to analyse and steer municipal water and wastewater (WW) activities toward sustainability. A consistent trend in national results from SI across all years is that while day-to-day operations are working well, there are deficiencies in strategies for long-term planning. The nationalresults show

We present a recipe for building a portable DIY toolkit, entitled Kitchen-Based Light Tomography (KBLT) for performing tomography using visible light with low-cost and easily accessible components. We also present different use cases to mimic different challenges in tomography, such as imaging time evolving samples. All the software for motor controls, image acquisition, image reconstruction and a

Comparing 3D neutron and X-ray microtomography (NCT and XCT) results of fully pyrolyzed and pristine samples, we observed that the contrast in the neutron images increased for the carbonized samples, suggesting that H would be concentrated at the surface of the carbonized material structure.

The aim of this thesis was to explore the perceptions of, prerequisites for and benefits of user involvement among older people, persons with functional impairments and other user groups important to the research area. By using an adapted conceptual tool to categorize the various user involvement studies comprising the thesis, the aim wasalso to reflect on the importance of study design for the ou

I varje svensk kommun finns ett bibliotek som alla invånare ska ha tillgång till. Men vilken roll ska bibliotek ha i framtidens stadsrum? Detta undersöks i projektet ILIT där forskarna Johanna Rivano Eckerdal och Lisa Engström medverkar.

Hard learning problems are central topics in recent cryptographic research. Many cryptographic primitives relate their security to difficult problems in lattices, such as the shortest vector problem. Such schemes include the possibility of decryption errors with some very small probability. In this paper we propose and discuss a generic attack for secret key recovery based on generating decryption

The prevalence of mental ill-health is increasing among young people in many developed countries, raising concerns about their well-being. Experts have pointed to several potential contributing factors, including a heightened emphasis on educational achievement and performance evaluation, as well as shifting demands in the high-skilled job market. In this paper, we study the effect of introducing

Monitoring insects of different species to understand the factors affecting their diversity and decline is a major challenge. Laser remote sensing and spectroscopy offer promising novel solutions to this. Coherent scattering from thin wing membranes also known as wing interference patterns (WIPs) have recently been demonstrated to be species specific. The colors of WIPs arise due to unique fringy

In-situ characterization of combusting iron particles is of great importance for understanding the combustion mechanism. Here, magnified holographic imaging is employed to investigate the transient morphology and dynamics of iron particles during combustion. The volume expansion behavior of combusting particles (mean diameter: 85 μm) is observed in situ. The particle volume increases to eight time

Semaphorin 3B (SEMA3B) is a secreted axonal guidance molecule that is expressed during development and throughout adulthood. Recently, SEMA3B has emerged as a tumor suppressor in non-neuronal cells. Here, we show that SEMA3B is a direct target of GATA3 transcriptional activity. GATA3 is a key transcription factor that regulates genes involved in mammary luminal cell differentiation and tumor suppr

Eye tracking has been used as part of software engineering and computer science research for a long time, and during this time new techniques for machine learning (ML) have emerged. Some of those techniques are applicable to the analysis of eye-tracking data, and to some extent have been applied. However, there is no structured summary available on which ML techniques are used for analysis in diff

Why do some genomes stay small and simple, while others become huge, and why are some genomes more stable? In contrast to angiosperms and gymnosperms, liverworts are characterized by small genomes with low variation in size and conserved chromosome numbers. We quantified genome evolution among five Marchantiophyta (liverworts), measuring gene characteristics, transposable element (TE) landscape, c

The accuracy of pore size distributions (PSD) obtained from gas adsorption and cryoporometry is compromised by the presence of advanced adsorption and advanced melting effects, respectively. In order to improve PSD accuracy, it is necessary to know the extent of such effects. In this work cryoporometry and adsorption have been combined to study the onset of advanced melting effects in a sample par

Two competing predictions regarding highly dispersible clonal plants, such as bryophytes, expect levels of genetic diversity to either increase or decrease over time following a disturbance that opens habitat for colonization. Following up on previous research that found higher levels of genetic variation in bryophytes from relatively undisturbed forest sites, we examined unisexual, haploid specie

Surtsey island was formed in a volcanic eruption south of Iceland in 1963 – 1967 and has since then been protected and monitored by scientists. It is the youngest island in the Vestmannaeyjar archipelago. The archipelago is of volcanic origin, but the other islands are ca. 5 000 to 40 000 yrs old. The first two moss species were found on Surtsey as early as 1967 and several new bryophyte species w

In Europe, individualist societies, in which people more highly value independence, have fewer people who are lonely. Yet these societies also have more people who live alone, a strong determinant of loneliness. Evidence suggests that some unrecognized societal-level resources or characteristics can explain this.We uncover multiple pathways toward a lower degree of loneliness among European societ

UNLABELLED: Isocitrate dehydrogenase 1 and 2 (IDH) are mutated in multiple cancers and drive production of (R)-2-hydroxyglutarate (2HG). We identified a lipid synthesis enzyme [acetyl CoA carboxylase 1 (ACC1)] as a synthetic lethal target in mutant IDH1 (mIDH1), but not mIDH2, cancers. Here, we analyzed the metabolome of primary acute myeloid leukemia (AML) blasts and identified an mIDH1-specific