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The ECM exerts great effects on cells, and changed composition may therefore have profound impact. Small leucine-rich proteoglycans, e.g. fibromodulin, are essential in collagen assembly. Our aim was to investigate the role of fibromodulin in healthy and fibrotic lung parenchyma, theorizing that fibromodulin-deficient animals would be protected against fibrosis. Repeated subcutaneous bleomycin-inj
It can be said that literary texts do not have any obligation to reality, and that literature destabilises our relations to the everyday use of words and to established perspectives. Literature stands in relation to something that cannot be explained or conceptualised, and in this respect it is close to religion. I argue that many of these characteristics of literature are also features of philoso
Objective. The current study used islet amyloid polypeptide (IAPP) knockout mice (KO mice) to investigate the physiological role of IAPP in the regulation of food intake (FI). Material and methods. FI and body weight were measured in KO and wild-type (WT) mice for 27 weeks. In an additional short-term experiment, IAPP (25 pmol . kg(-1)min(-1)) was infused subcutaneously for 3 days in KO and WT mic
Iterated filtering is an algorithm for estimating parameters in partially observed Markov process (POMP) models. The real-world performance of the algorithm depends on several tuning parameters. We propose a simple method for optimizing the parameter governing the joint dynamics of the hidden parameter process (called the Sigma matrix). The tuning is implemented using a fixed-lag sequential Monte
This paper presents a decoder for multi-carrier modulated signals employing Faster-than-Nyquist (FTN) signaling. FTN signaling is a method of improving bandwidth efficiency at the expense of higher processing complexity in the transceiver. The decoder can switch between orthogonal and FTN signaling modes and exploits channel properties to improve bandwidth efficiency. The decoder is fabricated in
The legitimacy of the judiciary hinges on the presumption that truth can be found through the judicial process. Even though a distinction can be made between "truth" in a legal sense and "real truth", the legal truth can only be justified by its anchorage in "real truth". During the last few decades, the previosly all-powerful assumption of the objective nature of reality and knowledge has been ch
The dynamic phase diagram of triethylene glycol dodecyl ether (C12E3) in D2O was determined for 40, 50, and 60 wt % of surfactant. The shear flow effect on the nonionic lamellar phase was investigated as a function of temperature and concentration. The transition from planar lamellae (L-alpha)-to-multilamellar vesicles (MLVs) was characterized by means of rheology, rheo-small-angle neutron and lig
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb[Formula: see text] of [Formula: see text] TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with [Formula: see text] GeV and no leptons. Nine signal regions are considered with increasing mi
GaP < 111 > B nanowires are dominated by (111) twins orthogonal to the growth direction and show well-developed {111} side-facets. Based on this, a 3D-model has been constructed with a cross-section of an octahedron used as a building block. The twins can be of ortho- or para type i.e. by 60 degrees about the growth axis or 180 degrees in the twin plane. The segment thickness variation follows an
This special issue celebrates the work of Bengt-Ake Lundvall on his 70th birthday. In the 1980s and 1990s he was a key player among a small group of academics in the USA and Europe that developed a new, systemic approach to the study of the interactions between science, innovation, and policy. He contributed to the popularity of the approach in the policy community in several ways, among other thi
Downscaling of microfluidic cell culture and detection devices for electrochemical monitoring has mostly focused on miniaturization of the microfluidic chips which are often designed for specific applications and therefore lack functional flexibility. We present a compact microfluidic cell culture and electrochemical analysis platform with in-built fluid handling and detection, enabling complete c
Quantitative measurements of hydrogen cyanide (HCN) were nonintrusively performed using mid-infrared polarization spectroscopy (IRPS) in atmospheric pressure flames. The lifted flat, laminar, premixed CH4/N2O/O-2/N-2 flames were stabilized on a 7 cm diameter home-built McKenna-type burner with variable proportion of N2O and O-2. The characteristic spectral structure of HCN molecules was identified
We present the design of a split-and-delay unit for the production of two delayed replicas of an incident extreme ultraviolet (XUV) pulse. The device features a single grazing incidence reflection in combination with attenuation of remaining infrared light co-propagating with the XUV beam, offering a high throughput without the need of introducing additional optics that would further decrease the
This paper presents a framework for policies development enabling growth of Nearshore in information and communications technologies (ICT) services inside European Community (EC), which are based in Portuguese companies, emphasizing what is needed to explore the huge opportunity to develop exportations, employability and the national economy. In a market of ICTs Outsourcing services forecasted in
