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Nearly all mammalian cells express a set of genes known as clock genes. These regulate the circadian rhythm of cellular processes by means of negative and positive autoregulatory feedback loops of transcription and translation. Recent genomewide association studies have demonstrated an association between a polymorphism near the circadian clock gene CRY2 and elevated fasting glucose. To determine
Background: Hip fracture is associated with high mortality. Cardiovascular disease and other comorbidities requiring long-term anticoagulant medication are common in these mostly elderly patients. The objective of our observational cohort study of patients undergoing surgery for hip fracture was to study the association between preoperative use of low-dose acetylsalicylic acid (LdAA) and intraoper
Ageing populations and higher ambitions continuously drive healthcare costs in Sweden and worldwide. During the last two decades, downsizing hospital bed capacity has been the strategy for cutting expenditure in the Swedish healthcare system. However, the lack of implementation of new and viable outpatient alternatives has led to a widespread overcrowding problem in Swedish hospitals and emergency
In this paper the Dirichlet problem for a class of standard weighted Laplace operators in the upper half plane is solved by means of a counterpart of the classical Poisson integral formula. Boundary limits and representations of the associated solutions are studied within a framework of weighted spaces of distributions. Special attention is given to the development of a, suitable uniqueness theory
This paper investigates why all-inclusive travel packages are offered at some hotels but not at others. Using the theory of transaction cost, it is argued that all-inclusive contracts mitigate a hold-up problem and that the severity of this problem varies with regard to the hotel's distance from the resort centre. This hypothesis is tested empirically against data from 3,798 hotel offers and is st
Aluminium oxyhydroxide, Al(OH)(3) is one of few compounds approved as an adjuvant in human vaccines. However, the mechanism behind its immune stimulating properties is still poorly understood. In vitro co-culture of an aluminium adjuvant and the human monocytic cell line THP-1 resulted in reduced cell proliferation. Inhibition occurred at concentrations of adjuvant several times lower than would b
This study compares glomerular filtration rate (GFR) equations in children based on standardized cystatin C (CYSC) and creatinine (CREA) and their combinations with renal clearance of inulin (C-inulin). A total of 220 children with different renal disorders were referred for C-inulin (median 84 ml/min/1.73 m(2)). Bias, precision (interquartile range, IQR), and accuracy (percentage of estimates +/-
This article reports on a search for dark matter pair production in association with bottom or top quarks in [Formula: see text] of [Formula: see text] collisions collected at [Formula: see text] TeV by the ATLAS detector at the LHC. Events with large missing transverse momentum are selected when produced in association with high-momentum jets of which one or more are identified as jets containing
Aerosols affect precipitation by modifying cloud properties such as cloud droplet number concentration (CDNQ. Aerosol effects on CDNC depend on aerosol properties such as number concentration, size spectrum, and chemical composition. This study focuses on the effects of aerosol chemical composition on CDNC and, thereby, precipitation in a mesoscale cloud ensemble (MCE) driven by deep convective cl
Enteral exposure of suckling rats to phytohaemagglutinin (PHA) has been shown to induce growth and precocious functional maturation of the gastrointestinal tract. The aim of the present study was to explore the mechanism of this action. Suckling rats, 14 d old, were fed a single dose of PHA (0.05 mg/g body weight) or saline. The binding of PHA to the gut epithelium and its effect on the morphology
We investigated the smooth muscle contraction in response to noradrenaline (NA), endothelin-1 (ET) and 5-hydroxytryptamine (5-HT) in the omental artery and vein segments from a 67-year-old woman with idiopathic orthostatic hypotension. The blood vessels were obtained during the abdominal surgery and investigated in vitro. Noradrenaline, endothelin-1 and 5-hydroxytryptamine all induced a contractio
A novel technique for measuring droplet temperatures has been demonstrated. Laser-induced phosphorescence from thermographic phosphors, seeded to distilled water and iso-octane, was used to measure temperatures of single falling droplets. The phosphors were excited by the fourth and third harmonies of a Nd:YAG laser. The subsequent emission was evaluated by spectral and temporal investigations of
Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22 called the Philadelphia (Ph) chromosome. In 2-10% of the cases, this chimeric gene is generated by variant rearrangements, involving 9q34, 22q11, and one or several other genomic regions. All chromosomes hav
Porous network structures were prepared by in situ polymerisation of a mixture of N-phenylmaleimide and 1, 1'-(methylenedi-4,1-plienylene)bismaleimide (95:5 w/w) in poly(vinylidene difluoride-co-hexafluoropropylene) (PVDH). The mixture of the maleimide monomers was found to form thermoreversible gels with PVDH. Thermodynamic analysis of the gelation process using calorimetry data indicated the for
This paper focuses on older peoples’ needs as pedestrians by examining their perceptions of the outdoor environment in both bare-ground and snow/ice conditions. Qualitative and quantitative methods are used, including focus group interviews, participant observations, and questionnaires. The results show that older people consider accessibility/usability issues as very important and that the import
The effects from thermal shock loading on pre-existing microcracks within thermal barrier coatings (TBCs) have been investigated through a finite element based fracture mechanical analysis. The TBC system consists of a metallic bond coat and a ceramic top coat. The rough interface between the top and bond coats holds an alumina oxide layer. Stress concentrations at the interface due to the interfa
High-level quantum-chemical methods show that the binding in the inclusion complex of hexamethylbenzene (HMB) in 6-cycloparaphenitacetylene (6-CPPA) cannot be explained only in terms of electrostatic interactions-caused by the polarization associated to curved a-conjugated systems-and the inclusion of dispersion forces is definitely needed. The theoretical description of van der Wools interactions
