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No benefit of ticagrelor pretreatment compared with treatment during percutaneous coronary intervention in patients with ST-segment⇓elevation myocardial infarction undergoing primary percutaneous coronary intervention

Background—The effects of ticagrelor pretreatment in patients with ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI) is debated. This study investigated the effects of ticagrelor pretreatment on clinical outcomes in this patient group. Methods and Results—Patients with ST-segment–elevation myocardial infarction undergoing primary PCI were includ

Lightguiding of Fluorescence in Nanowires : Principles, Optimization and Implementation for Biosensing

Due to their unique optical properties, III-V nanowires are promising candidates for the development of efficient solar cells, LEDs and nanoscaled lasers. The interaction of nanowires with fluorescent molecules is also of interest, as these nanostructures can act as nanoscaled optical fibers. The light emitted by a fluorophore close to a nanowire surface can in fact couple into the supported waveg

Search for B - L R-parity-violating top squarks in √s=13 TeV pp collisions with the ATLAS experiment

A search is presented for the direct pair production of the stop, the supersymmetric partner of the top quark, that decays through an R-parity-violating coupling to a final state with two leptons and two jets, at least one of which is identified as a b-jet. The data set corresponds to an integrated luminosity of 36.1 fb-1 of proton-proton collisions at a center-of-mass energy of √s= 13 TeV, collec

Neuroblastoma with flat genomic profile : A question of representativity?

Neuroblastoma is one of the most common paediatric malignancies. Detection of somatic genetic alterations in this tumour is instrumental for its risk stratification and treatment. On the other hand, an absence of detected chromosomal imbalances in neuroblastoma biopsies is difficult to interpret because it is unclear whether this situation truly reflects the tumour genome or if it is due to subopt

Kylbehandling efter förlossningsasfyxi minskar skadeutveckling : Barn med cerebral pares får bättre funktion, visar retrospektiv genomgång i kvalitetsregistret CPUP

Hypothermic treatment after birth asphyxia was introduced as a recommended practice in Sweden in 2007. CPUP is a national quality register and surveillance program that encompasses the total population of children with cerebral palsy (CP) in Sweden. In an analysis of CPUP data children with CP and asphyxia treated with cooling were compared to children with CP and asphyxia who were not cooled. A l

Fluid deficits during prolonged overnight fasting in young healthy adults

Background: Overnight fasting is often prolonged before scheduled surgery, and the extent of perioperative fluid replacement may influence outcome. In clinical practice, basic requirements are estimated at 1.2-2.0 mL·kg−1·h−1, but there is little contemporary clinical data on what deficits result from complete fasting. This prospective preclinical study was designed to determine total fluid loss d

Making sense of YouTubers : how Swedish children construct and negotiate the YouTuber Misslisibell as a girl celebrity

When children use the Internet, they commonly choose to watch their favorite YouTubers. In this article, we aim to deepen the understanding of how children make sense of YouTubers as a phenomenon, and the role of microcelebrities in children’s everyday life. The study is based on group interviews with 9- and 12-year-old Swedish children, and pays specific attention to how they make sense of the vi

Non-alcoholic fatty liver disease is a strong predictor of coronary artery calcification in metabolically healthy subjects : A cross-sectional, population-based study in middle-aged subjects

Objectives This study aims to estimate the relationship between non-alcoholic fatty liver disease (NAFLD) and measures of atherosclerotic cardiovascular disease (ASCVD), and to determine to what extent such relationships are modified by metabolic risk factors. Methods The study was conducted in the population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot cohort (n = 1015, age 50–64 y

Re-inforcing the cell death army in the fight against breast cancer

Metastatic breast cancer is responsible for most breast cancer-related deaths. Disseminated cancer cells have developed an intrinsic ability to resist anchorage-dependent apoptosis (anoikis). Anoikis is caused by the absence of cellular adhesion, a process that underpins lumen formation and maintenance during mammary gland development and homeostasis. In healthy cells, anoikis is mostly governed b

Continuous Model Validation using Reference Attribute Grammars

Just like current software systems, models are characterised by increasing complexity and rate of change. Yet, these models only become useful if they can be continuously evaluated and validated. To achieve sufficiently low response times for large models, incremental analysis is required. Reference Attribute Grammars (RAGs) offer mechanisms to perform an incremental analysis efficiently using dyn

Density-based particle fractionation

We present a label-free method capable of rapidly sorting particles based on their densities. Our device relies on deterministic lateral displacement (DLD) and achieves density fractionation by the use of T-shaped posts. By combining it with a lateral density gradient we achieve a density separation that is independent of size within a range given by the device geometry. Herein we present a proof-