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Objective: Evaluation of colposcopic and histopathological findings in women screened for cervical human papillomavirus deoxyribonucleic acid persistence. Study design: A total of 12527 women, aged 32 to 38 years old, attending the population-based cervical cancer screening program in Sweden were randomized 1:1 to mock testing or human papillomavirus deoxyribonucleic acid testing by general primer

Objective. To investigate the prevalence of current and chronic pain and their relationship to pain intensity, sex, age, income, employment status, citizenship, marital status, urban residence, occupational activity, and healthcare-seeking based on a representative sample from a Swedish county. Methods. A cross-sectional survey using a postal questionnaire was sent to a representative sample (n =

Previous studies on patients with breast cancer, who received postsurgical irradiation, displayed a markedly suppressed inflammatory response in the lung of smoking patients compared to nonsmokers. The aim of the present study was to investigate further the effect of exposure to tobacco smoke on the development of irradiation-induced pneumonitis in the rat. Four groups of animals were used: contro

The hallmark of severe haemophilia, defined as a circulating level of factor (F) VIII (haemophilia A cases) or FIX (haemophilia B cases) of < 1%, is recurrent bleeding into muscles and joints (haemarthroses) from an early age of life. The inevitable result of such bleeding is progressive joint damage, leading to disabling arthritis that is typically evident within the first 2 decades of life in pe

Web sites are exposed to high rates of incoming requests. Since web sites are sensitive to overload, admission control mechanisms are often implemented. The purpose of such a mechanism is to prevent requests from entering the web server during high loads. This paper presents how admission control mechanisms can be designed and implemented with a combination of queueing theory and control theory. S

Chromosome segment 12q13 -> q15 recombines with many different chromosome bands in lipomas and at least ten recurrent translocations have been identified. The HMGA2 gene is often rearranged, but little is known about the molecular consequences at other breakpoints. Fusion genes between HMGA2 (12q14 -> q15) and LPP (3q27 -> q28), LHFP (13q12) and CMKOR1 (2q37) have been reported. In the present stu

In neonatal retinal explants cultured long-term green cones are missing. Recently it was reported that thyroid hormone beta2 receptors (TR-beta2) are essential for these green cones to differentiate. Therefore transcript level of these receptors was investigated in our mouse retinal explants. However, thyroid receptors function as heterodimers with retinoid receptors (RR); so the fate of selected

Background New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with early rheumatoid arthritis. Methods We undertook a randomised trial in 15 rheumatology uni

Recent studies show that plant organ positioning may be mediated by localized concentrations of the plant hormone auxin. Auxin patterning in the shoot apical meristem is in turn brought about by the subcellular polar distribution of the putative auxin efflux mediator, PIN1. However, the question of what signals determine PIN1 polarization and how this gives rise to regular patterns of auxin concen

The objective of the present study was to assess the performance and recent improvements of the land surface scheme used operationally in the European Centre for Medium-Range Weather Forecasts (ECMWF) in a Scandinavian boreal forest climate/ecosystem. The previous (the 1999 scheme of P. Viterbo and A. K. Betts) and the new (Tiled ECMWF Surface Scheme for Exchange Processes over Land, TESSEL) surfa

Structural and mechanistic aspects of orthoplatination of acetophenone and benzaldehyde oximes by the platinum(II) sulfoxide and sulfide complexes [PtCl2L2] (2, L = SOMe2 (a), rac-SOMePh (b), R-SOMe(C6H4Me-4) (c), and SMe2 (d)) to afford the corresponding platinacycles cis-(CS)-[Pt-II(C6H3-2-CR'=NOH-5-R)CI(L)] (3, R, R' = H, Me) have been investigated. The reaction of acetophenone oxime with sulfo

We investigated the variation in concentration of orientation among nocturnally migrating passerine birds. Using tracking radar, we recorded flight tracks of birds during spring and autumn migration and, with the aid of concurrent wind recordings, we calculated heading directions. The concentrations of track and heading directions were compared between seasons and also between different categories

In a prospective pilot study nested in the EPIC-Oxford cohort, we examined the seroprevalence of antibodies against the L1 antigen of 38 human papilloma virus (HPV) types among 39 cases of cutaneous squamous cell carcinoma (SCC) for whom plasma was collected prior to diagnosis (incident) and 80 controls. Fifteen cases having already developed SCC at blood collection (prevalent) were also tested. T

E3B1, a human homologue of the mouse gene product Abi-1, has been implicated in growth-factor-mediated regulation of the small GTPases p21(Ras) and Rac. E3b1 is a regulator of Rac because it can form a complex with Sos-1 and eps8, and such a Sos-1-e3B1-eps8 complex serves as a guanine nucleotide exchange factor for Rac. In the present study, we found that overexpression of e3B1 in NIH3T3/ EGFR cel

Conversion of lignocellulosic material to monomeric sugars and finally ethanol must be performed at low cost, i.e, with limited consumption of chemicals, yeast and enzymes while still reaching high yields, if it is to compete with other fuel conversion processes. The objective of this study was thus to investigate ethanol production from steam-pretreated wheat straw by simultaneous saccharificatio