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Analysing cylindromatosis and the associated defects in the CYLD gene is providing novel insights into the molecular principles of epithelial growth control and carcinogenesis in, and beyond, the skin. In this review, we summarize the histopathology and histogenesis of cylindromas, and the available genetic information on patients with these skin appendage tumors. Focusing on recent data concernin

Purpose: To assess the performance of activities of daily living (ADL) in individuals with moderate to severe multiple sclerosis (MS). Method: A total of 12 men and 32 women with MS ( Expanded Disability Status Scale, EDSS, 6.0-8.5) were studied. The performance of personal ADL (P-ADL) and instrumental ADL (I-ADL) was assessed with the Functional Independence Measure (FIM) and the Assessment of Mo

In the present study, using retinal ischemia as a model, we examined if different periods of ischemia and recirculation influenced the generation of reactive oxygen species, i.e. in hydrogen peroxide generation and nitroblue tetrazolium (NBT) reduction. Ischemia was induced for 30 and 90 min by ligation of the optic nerve with the vessels and recirculation was established by removing the ligature.

The Ulvo Gabbro Complex (UGC) belongs to the 1.27-1.25 Ga Central Scandinavian Dolerite Group (CSDG), which manifests a major event of intra-cratonic mafic magmatism possibly related to break-up between Laurentia and Baltica. Lopolithic, layered intrusions of the UGC outcrop in east central Sweden and west central Finland. Fresh baddeleyite grains in a pegmatoidal gabbro were dated by the TIMS U-P

We demonstrate high-fidelity guidance of axons using rows of nanowires. The axons are prevented from crossing the rows, making it possible to guide and sort a large number of axons as opposed to when chemical patterns are used. Focal adhesion forms at the nanowires establishing a possible site of information transfer between the surface and the cells. Rows of gallium phosphide (GaP) nanowires were

We report on the shear-induced transition from an oriented lamellar phase (L, phase) to multilamellar vesicles (MLV) in two nonionic surfactant systems, namely, a 40 wt % sample of triethylene glycol monodecyl ether (C10E3) and a 40 wt % sample of tetraethylene glycol monododecyl ether (C12E4) in D2O. This transition was studied by time-resolved small-angle neutron and light scattering under shear

High-pressure homogenization of modified starches is a type of treatment used within the food and pharmaceutical industry for the production of emulsions. Such intense mechanical treatment may, however, influence the size and size distribution of the starch polymer, which may affect the properties of the emulsions. In this work, asymmetrical flow field-flow fractionation (AsFIFFF) connected on-lin

Ezetimibe inhibits cholesterol absorption in the intestine. Sphingomyelin has strong interactions with cholesterol. We investigated the effects of ezetimibe on Sphingomyelinase (SMase) expression in intestine and liver. After feeding rats with ezetimibe (5 mg/kg per day) for 14 days, acid SMase activities in the liver and in the proximal part of small intestine were reduced by 34 and 25%, respecti

Prevotella bivia has been associated with female upper genital tract infections and an increased risk of preterm delivery. In this study, the adherence and invasion capacity of P. bivia was investigated using a cervix epithelial cell line. P. bivia was furthermore analysed for its ability to evoke a proinflammatory cytokine response in epithelial cells. The invasion capacity, defined as the number

Purpose: To describe an alternative hybrid endovascular/open approach to revascularizing the occluded superior mesenteric artery (SMA) in patients with acute ischemia. Technique: A laparotomy is performed to assess any visceral ischemia. The SMA is exposed, clamped distally, and cannulated proximally. The SMA occlusion is crossed in a retrograde fashion. Balloon embolectomy or stent implantation m

The adsorption of cellulases on steam-pretreated willow has been measured for2, 4, and 8 wt% willow and with varying enzyme concentrations (2–100 wt% based on substrate). The enzyme concentration was measured as soluble protein, filter paper activity (FPA), CMC-ase activity, and activity toward willow. The adsorption data were modeled with a Langmuir isotherm. The maximum adsorption capability dep

Iron uptake in Arabidopsis thaliana is mediated by ferric chelate reductase FRO2, a transmembrane protein belonging to the flavocytochrome b family. There is no high resolution structural information available for any member of this family. We have determined the transmembrane topology of FRO2 experimentally using the alkaline phosphatase fusion method. The resulting topology is different from tha

This study investigates four questions: First, whether there is a relationship between imaginary companions and creative potential; second, whether children with negative self-images are more likely to have imaginary companions; third, whether there are gender differences among those children who have imaginary companions; and, finally, what aspects of imaginary companions and what characteristics

We present a combined theoretical and experimental study of ultrafast wave-packet dynamics in the dissociative ionization of H-2 molecules as a result of irradiation with an extreme-ultraviolet (XUV) pulse followed by an infrared (IR) pulse. In experiments where the duration of both the XUV and IR pulses are shorter than the vibrational period of H-2+, dephasing and rephasing of the vibrational wa