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Identification of two C-terminal autophosphorylation sites in the PDGF beta-receptor: involvement in the interaction with phospholipase C-gamma

Two novel sites of autophosphorylation were localized to the C-terminal tail of the PDGF beta-receptor. To evaluate the importance of these phosphorylation sites, receptor mutants in which Tyr1009, Tyr1021 or both were replaced with phenylalanine residues, were expressed in porcine aortic endothelial (PAE) cells. These mutants were similar to the wild type receptor with regard to protein tyrosine

Alltings mått: frågan om Protagoras' humanism

Förhärskande tolkningstraditioner betraktar sofisten Protagoras som företrädare för en antropocentrisk humanism, som gör allt relativt till en värdeskapande och meningsgivande mänsklighet eller mänsklig individ, och därmed en centralgestalt (vid sidan av Sokrates) i den grekiska vändningen från natur till kultur under 400-talet f.Kr. Det är dessa betydelser som brukar ges hans välkända maxim: ”MänIn opposition to the traditional interpretation of Protagoras's Homo Mensura-Satz ("Man is the measure of all things") as a founding tenet of Western humanism, this essay challenges the notion of an inherent anthropocentrism of the dictum (that all things are relative to man as species or individual). In a reading of the most important sources of antiquity, namely Plato, Aristotle and Sextus Empir

Jejunal pouch reconstruction but not preservation of duodenal passage after total gastrectomy reduces plasma cholecystokinin and pancreatic polypeptide long term in pigs.

AIM: The long-term effects of reconstructions of the gastrointestinal tract after gastrectomy on plasma levels of gastrointestinal hormones that contribute to food intake controls were evaluated. MATERIALS AND METHODS: Domestic pigs were randomly assigned to sham-surgery or total gastrectomy followed by reconstruction with oesophagojejunostomy on a Roux-en-Y loop (OJRY), jejunal interposition betw

Optimization of Radiation Exposure and Image Quality of the Cone-beam O-arm Intraoperative Imaging System in Spinal Surgery.

STUDY DESIGN: Retrospective study. OBJECTIVES: To optimize the radiation doses and image quality for the cone-beam O-arm surgical imaging system in spinal surgery. SUMMARY OF BACKGROUND: Neurovascular compromise has been reported after screw misplacement during thoracic pedicle screw insertion. The use of O-arm with or without navigation system during spinal surgery has been shown to lower the rat

Landscape Change in Peri-Urban Areas: a Comparison of Kenya and Southern Sweden

Peri-urban development has in recent years been given increasing attention in different regions all over the world. Peri-urban areas are defined as zones of conflict or competition where new and traditional land uses collide with outer reaches demarcated by daily commuting distances based on common modes of transport into urban cores. In this article an effort to compare peri-urban development in

Age and gender differences in the association between Nt-proBNP and glucometabolic disturbances.

Abstract Objectives. Glucometabolic disturbances are associated with myocardial dysfunction. Brain natriuretic peptides (BNP) are used for detecting myocardial dysfunction in clinical practice. However, studies on elderly subjects and gender-specific analyses are sparse. Design. We examined cross-sectional associations between Nt-proBNP and 1) fasting plasma glucose (FPG), and 2) categories of glu

Fatigue in out-patients with inflammatory bowel disease is common and multifactorial.

Background Patients with inflammatory bowel disease (IBD) often complain of fatigue. Aim To investigate the prevalence and characteristics of fatigue among IBD out-patients in Scandinavia and to provide normative values for fatigue in IBD patients. Methods A cross-sectional study was conducted on 425 IBD patients from six out-patient centres in Denmark, Norway and Sweden. Fatigue was measured usin