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Spectral sensitivity in Onychophora (velvet worms) revealed by electroretinograms, phototactic behaviour and opsin gene expression.

Onychophorans typically possess a pair of simple eyes, inherited from the last common ancestor of Panarthropoda (Onychophora + Tardigrada + Arthropoda). These visual organs are thought to be homologous to the arthropod median ocelli, whereas the compound eyes most likely evolved in the arthropod lineage. To gain insights into the ancestral function and evolution of the visual system in panarthropo

Wave propagation in birefringent materials with off-axis absorption or gain

The polarization direction of an electromagnetic field changes and eventually reaches a steady state when propagating through a birefringent material with off-axis absorption or gain. The steady state orientation direction depends on the magnitude of the absorption (gain) and the phase retardation rate. The change in the polarization direction is experimentally demonstrated in weakly doped (0.05%)

Talking work in a bank: A study of organizing properties of leadership in work interactions

Leadership is generally seen not only as an inspiring and motivating force but also as having important organizing properties. Despite this common assumption, the organizing properties of leadership have not yet been clarified sufficiently or demonstrated empirically. In this study, such organizing properties are revealed through a detailed analysis of one single work episode, drawn from an ethnog

A unique 3D endoanal ultrasound feature of perianal Crohn's fistula:the "Crohn ultrasound fistula sign" (CUFS).

Aim: Using a high-resolution 3D endoanal ultrasound, we have observed that some perianal fistulas show a hypoechogenic fistula tract surrounded by a well-defined hyperechogenic area with a thin hypoechogenic edge outside characterized fistulas in patients with Crohn's disease ("Crohn's Ultrasound Fistula Sign" (CUFS)), unlike conventional fistula tracks.. The study aimed to determine the prevalenc

Moisture sorption and swelling of Norway spruce [Picea abies (L.) Karst.] impregnated with linseed oil

The moisture sorption and swelling of spruce specimens impregnated with linseed oil and unimpregnated controls were studied in two sorption experiments: from 0 to 55% relative humidity (RH) and from 55% RH to water saturation. Sorption isotherms were also determined using a sorption balance. The impregnated specimens had lower rates of both moisture sorption and swelling than the unimpregnated con

Cysteinyl leukotrienes and their receptors: Bridging inflammation and colorectal cancer.

Long-standing inflammation has emerged as a hallmark of neoplastic transformation of epithelial cells and may be a limiting factor of successful conventional tumor therapies. A complex milieu composed of distinct stromal and immune cells, soluble factors and inflammatory mediators plays a crucial role in supporting and promoting various types of cancers. An augmented inflammatory response can pred

Safety, tolerability, and antibody response of active A beta immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study

Background Immunotherapy targeting the amyloid beta (A beta) peptide is a potential strategy to slow the progression of Alzheimer's disease. We aimed to assess the safety and tolerability of CAD106, a novel active A beta immunotherapy for patients with Alzheimer's disease, designed to induce N-terminal A beta-specific antibodies without an A beta-specific T-cell response. Methods We did a phase 1,

A generalized birthday approach for efficiently finding linear relations in l-sequences

Feedback with carry shift registers (FCSRs) have previously been available in two configurations, the Fibonacci and Galois architectures. Recently, a generalized and unifying FCSR structure and theory was presented. The new ring FCSR model repairs some weaknesses of the older architectures. Most notably, the carry cell bias property that was exploited for an attack on the eSTREAM final portfolio c

Organizational Adaptation in Multi-Stakeholder Crisis Response: An Experimental Study

Modern day crises demand organizations to collaborate and adapt to new roles, functions and structures. In such situations, lack of collaborative behaviour and openness between organizations can result in reduced adaptive ability. Therefore, it is important to facilitate collaboration between organizations.We have studied the extent to which crisis managers are prepared to work with personnel and

g-factor Measurements at RISING: The Cases of 127Sn and 128Sn

We report on g-factor measurements of the 19/2(+) T-1/2 = 4.5(3) mu s isomer in Sn-127 and the 10(+) T-1/2 = 2.69(23) mu s isomer in Sn-128. These isomers were produced and spin-aligned in relativistic heavy-ion fragmentation at GSI and were selected and separated by the GSI fragment separator ( FRS). The gamma-rays of the isomeric decay were detected by the RISING gamma-ray spectrometer. The meth

Stroke: working toward a prioritized world agenda

Background and Purpose The aim of the Synergium was to devise and prioritize new ways of accelerating progress in reducing the risks, effects, and consequences of stroke. Methods Preliminary work was performed by seven working groups of stroke leaders followed by a synergium (a forum for working synergistically together) with approximately 100 additional participants. The resulting draft document

Response of a free-flying songbird to an experimental shift of the light polarization pattern around sunset

The magnetic field, the sun, the stars and the polarization pattern of visible light during twilight are important cues for orientation in nocturnally migrating songbirds. As these cues change with time and location on Earth, the polarization pattern was put forward as a likely key reference system calibrating the other compass systems. Whether this applies generally to migratory birds is, however

Knock-down of SOX11 induces autotaxin-dependent increase in proliferation in vitro and more aggressive tumors in vivo

Abstract in UndeterminedThe transcription factor SOX11 is a novel diagnostic marker for mantle cell lymphoma (MCL), distinguishing this aggressive tumor from potential simulators. Recent data also show that the level of SOX11 correlates to in vitro growth properties in MCL, as well as the clinical progression. We have previously shown that MCL-associated pathways, such as Rb-E2F, are dysregulated

How can measurement, monitoring, modeling and control advance cell culture in industrial biotechnology?

This report highlights the potential of measurement, monitoring, modeling and control ((MC)-C-3) methodologies in animal and human cell culture technology. In particular, state-of-the-art of (MC)-C-3 technologies and their industrial relevance of existing technology are addressed. It is a summary of an expert panel discussion between biotechnologists and biochemical engineers with both academic an

Hot spots of vegetation-climate feedbacks under future greenhouse forcing in Europe

We performed simulations of future biophysical vegetation-climate feedbacks with a regional Earth System Model, RCA-GUESS, interactively coupling a regional climate model and a process-based model of vegetation dynamics and biogeochemistry. Simulated variations in leaf area index and in the relative coverage of evergreen forest, deciduous forest, and open land vegetation in response to simulated c