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Commutativity and Ideals in Algebraic Crossed Products

We investigate properties of commutative subrings and ideals in non-commutative algebraic crossed products for actions by arbitrary groups. A description of the commutant of the coefficient subring in the crossed product ring is given. Conditions for commutativity and maximal commutativity of the commutant of the coefficient subring are provided in terms of the action as well as in terms of the in

Visualization of atomic processes on ruthenium dioxide using scanning tunneling microscopy

The visualization of surface reactions on the atomic scale provides direct insight into the microscopic reaction steps taking place in a catalytic reaction at a (model) catalyst's surface. Employing the technique of scanning tunneling microscopy (STM), we investigated the CO oxidation reaction over the RuO2(110) and RuO2(100) surfaces. For both surfaces the protruding bridging O atoms are imaged i

Protein GRAB of streptococcus pyogenes regulates proteolysis at the bacterial surface by binding alpha2-macroglobulin

In the molecular interplay between pathogenic microorganisms and their host, proteolytic mechanisms are believed to play a crucial role. Here we find that the important human pathogen Streptococcus pyogenes (group A Streptococcus) expresses a surface protein with high affinity (Ka = 2.0 x 10(8) M-1) for alpha2-macroglobulin (alpha2M), the dominating proteinase inhibitor of human plasma. The immuno

Activation of Hormone-sensitive Lipase Requires Two Steps, Protein Phosphorylation and Binding to the PAT-1 Domain of Lipid Droplet Coat Proteins

Lipolysis is an important metabolic pathway controlling energy homeostasis through degradation of triglycerides stored in lipid droplets and release of fatty acids. Lipid droplets of mammalian cells are coated with one or more members of the PAT protein family, which serve important functions in regulating lipolysis. In this study, we investigate the mechanisms by which PAT family members, perilip

Static and dynamic modeling of cardboard drying - Part 2: Simulations and experimental results

A general, dynamic model describing the drying mechanisms of paper has been developed. The model includes shrinkage and predicts temperature, moisture, and pressure profiles. It has been evaluated against steady-state as well as dynamic measurements oil a multicylinder paper dryer. The results revealed critical sections where low web strength and maximum gas pressure Occur. Measurements of the out

Silica: an essential nutrient in wetland biogeochemistry

Recent research has emphasized the importance of terrestrial ecosystems in the global biogeochemical cycle of silica (Si). The production, retention, and dissolution of amorphous silica of biological origin in soils and vegetation effectively control terrestrial Si fluxes. However, surprisingly little is known about the role of wetlands in these processes. Wetlands are known hotspots for both nitr

Lung edema formation during cold perfusion: Important differences between rat and porcine lung

Background: The aim of this study was to investigate the effect of different perfusion pressures on edema formation during cold flush perfusion with the 2 most commonly used preservation solutions in clinical lung transplantation: Euro-Collins and Perfadex solutions. Methods: Isolated rat and porcine lungs were perfused for 3 minutes at 4 degrees C to 8 degrees C at a pressure of either 10, 15 or

An invariant for unbounded operators

For a class of unbounded operators, a deformation of a Bott projection is used to construct an integer-valued invariant measuring deviation of the non-commutative deformations from the commutative originals, and its interpretation in terms of K-theory of C*-algebras is given. Calculation of this invariant for specific important classes of unbounded operators is also presented.

Autism spectrum conditons in myotonic dystrophy type 1: A study on 57 individuals with congenital and childhood forms

Myotonic dystrophy type 1 (DM1) is an autosomal dominant disorder, caused by an expansion of a CTG triplet repeat in the DMPK gene. The aims of the present study were to classify a cohort of children with DM1, to describe their neuropsychiatric problems and cognitive level, to estimate the size of the CTG expansion, and to correlate the molecular findings with the neuropsychiatric problems. Fifty-

Mass transfer in eccentric binaries: the new oil-on-water smoothed particle hydrodynamics technique

To measure the onset of mass transfer in eccentric binaries, we have developed a two-phase smoothed particle hydrodynamics (SPH) technique. Mass transfer is important in the evolution of close binaries, and a key issue is to determine the separation at which mass transfer begins. The circular case is well understood and can be treated through the use of the Roche formalism. To treat the eccentric

Naturally occurring mutations in the thrombomodulin gene leading to impaired expression and function

Sporadic mutations in the thrombomodulin (TM) gene occur in patients with both arterial and venous thrombosis, but the effects of these mutations on expression and function are largely unexplored. Full-length wild-type TM complementary DNA (cDNA) was incorporated into vector pcDNA6 for transfection into COS-7 cells for transient expression. Mutagenesis was performed to create 7 TM mutants with nat

One year boundary layer aerosol size distribution data from five nordic background stations

Size distribution measurements performed at five different stations have been investigated during a one-year period between 01 June 2000 and 31 May 2001 with focus on diurnal, seasonal and geographical differences of size distribution properties. The stations involved cover a large geographical area ranging from the Finnish Lapland (67degrees N) down to southern Sweden (56degrees N) in the order V

Surface-enhanced Raman scattering of rhodamine 6G on nanowire arrays decorated with gold nanoparticles

We investigate the surface-enhanced Raman scattering (SERS) of rhodamine 6G (R6G) adsorbed on Au nanoparticles attached to InP nanowires. We find that nanowire arrays act as frameworks for effective SERS substrates with a significantly higher Raman signal sensitivity than a planar framework of Au nanoparticles adsorbed two-dimensionally on a flat surface. The SERS signal displays a clear polarizat

Delivering needle-free insulin using AERx (R) iDMS (Insulin Diabetes Management System) technology

Background and Methods: Inhaled insulin has recently emerged as an alternative to subcutaneous insulin administration. One inhaled insulin device, AERx (R) (a registered trademark of Aradigm Corp., Hayward, CA, or its affiliates in the United States and other countries) insulin diabetes management system (iDMS) (Novo Nordisk A/S, Bagsvoerd, Denmark), uses a unique liquid human insulin strip to del

Role of group A streptococcal IgG-binding proteins in triggering experimental glomerulonephritis in the rabbit

Our previous studies have indicated that the IgG-binding M-family proteins (IgGBP) of group A streptococci may be involved in eliciting experimental acute poststreptococcal glomerulonephritis (APSGN) in the rabbit. These surface proteins were also found to trigger production of anti-IgG, which might conceivably act to enhance renal deposition of immune complexes (IC). In the present study, a clini

Treatment of end-of-dose wearing-off in Parkinson's disease: Stalevo (R) (levodopa/carbidopa/entacapone) and levodopa/DDCI given in combination with Comtess (R)/Comtan (R) (Entacapone) provide equivalent improvements in symptom control superior to that of traditional levodopa/DDCI treatment

The aim of this study was to evaluate the efficacy of the new optimised levoclopa, Stalevo(R) (levoclopa, carbidopa and entacapone) in patients with Parkinson's disease experiencing end-of-close wearing-off. Treatment with Stalevo was compared to treatment with traditional immediate-release levodopa and dopa-decarboxylase inhibitor (DDCl) formulations along with adjunct entacapone (Comtess(R)/Comt