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This article explores the intersection of pricing strategies and pricing capabilities by summarizing four distinct streams of research. By doing so, it provides insights into the challenges involved in implementing value-based pricing strategies as well as the generic challenges of building pricing capabilities. It also outlines the strategic importance of pricing capabilities.
To investigate the precision, accuracy, and repeatability of water/fat imaging-based fat quantification in muscle tissue using a large flip angle (FA) and a fat reference for the calculation of the proton density fat fraction (FF). Comparison is made to a small FA water reference approach.
Glypicans are a family of cell-surface proteoglycans that regulate Wnt, hedgehog, bone morphogenetic protein and fibroblast growth factor signaling. Loss-of-function mutations in glypican core proteins and in glycosaminoglycan synthezing enzymes have revealed that glypican core proteins and their glycosaminoglycan chains are important in shaping animal development. Glypican core proteins consist o
Small scale particles/pores from micrometers and down to nanometers often occur in multi-functional porous electrodes in fuel cells, to enhance the catalytic reaction activities and accordingly the cell performance. Multi-component and -phase mass transport phenomena of reactants and products are strongly coupled with other transport processes as well as various reactions. All these processes form
Multiple studies have established the superior diagnostic accuracy of video capsule endoscopy (VCE) for the diagnosis of small bowel (SB) Crohn's disease (CD). However, data on the clinical impact of VCE in patients with established CD are scarce. The aim of this study was to examine the impact and safety of VCE on the clinical management of patients with established CD.
Background: The Patient-Reported Indices for Multiple Sclerosis (PRIMUS) comprises a suite of three scales for assessing symptoms, activity limitations, and quality of life in multiple sclerosis (MS). It was developed in the UK and has been shown to have excellent psychometric properties. This study describes the adaptation of eight language versions for Canadian English, Canadian French, French,
BACKGROUND The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. METHODS We used a genetic approach to investigate the association between height and CAD, using 180 height-associated genetic variants. We tested the association between a change in genetically determined height of 1 SD (6.5 cm) with the risk of
The ecological debt concept emerged in the early 1990s from within social movements driven by rising environmental awareness, emerging Western consciousness of responsibility for past colonial subjugations, and a general sense of unease during the debt crisis. First developed organically, mainly in locally-scaled, civil contexts, ecological debt has since gained attention in academia and internati
In this work 80-picosecond laser pulses of 266-nm wavelength with intensities up to (2.0 +/- A 0.5) x 10(11) W/cm(2) were used for fragmentation of methane/air gas mixtures at ambient pressure and temperature. Emission spectra are, for the first time, studied with ultrahigh temporal resolution using a streak camera. Fluorescence spectra from CH(A(2)Delta-(XI)-I-2 , (BI)-I-2 (-)-(XI)-I-2 pound , (C
To realize selective mineralization of low-level chlorophenols (CPs) in the presence of high-level ordinary pollutants, molecularly imprinted polymers (MIPs) coated photocatalyst was prepared using substrate analog as template. The pseudo-template imprinted photocatalysts showed rapid decomposition ability toward a group of CPs. Based on the complete dechlorination and spectrophotometry, a new met
The aim of this cross-sectional study was to investigate the prevalence of overweight and obesity in children and adolescents (6-16 years), and relationships between being overweight and sleep, experiencing of fatigue, enjoyment of school, and time spent in watching television and in sitting at the computer. Trained school nurses measured the weight and height of 2891 children aged 6, 7, 10, 14, a
Women occupy a small minority of elite positions in contemporary society. In addition, the minority of women who gain access to influential elite positions are often assumed to have their actual influence circumscribed by mechanisms of marginalization. However, systematic evidence to support the latter view is relatively scarce. We apply social network analysis to study sex differences in local el
Several Zn-porphyrin (ZnP) derivatives were designed to build highly efficient dye-sensitized solar cells (DSC). It was found that solar cell efficiencies normalized for surface coverage (eta(rel)) are affected by the molecular spacer connecting the porphyrin core to the TiO2 surface, the sensitization conditions (solvent and time), and, to a lesser extent, the nature of the terminal group of the
Bipolar disorder (BD) is a severe illness that has a serious impact on the lives of those affected and on their families. The aim of this study was to elucidate what it means for family members to live with an adult person who has BD, with reference to their views concerning the condition of the person affected and the future. During 2005, 17 family members of people with the disorder were intervi
Introduction: Five different molecular subtypes of breast cancer have been identified through gene expression profiling. Each subtype has a characteristic expression pattern suggested to partly depend on cellular origin. We aimed to investigate whether the molecular subtypes also display distinct methylation profiles. Methods: We analysed methylation status of 807 cancer-related genes in 189 fresh
A variety of analyses, including fluorescence in situ hybridization (FISH), quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series of chordomas from 181 patients. Twelve of 181 (7%) tumours displayed amplification of the T locus and an additional two cases showed focal amplification; 70/181 (39%) tumours were polysomic for chromosome 6, and 8/181 (4.5%) primary tumours showe
BACKGROUND: Despite marked improvement in therapy and monitoring of patients with insulin-dependent (type 1) diabetes, diabetic nephropathy remains a serious complication, with subsequent end-stage renal disease in about 20% of cases. OBJECTIVE: To investigate in young patients with type 1 diabetes whether urine α-Glutathione S-transferase to creatinine ratio (α-GST:crea) relates to markers of s
Introduction: Airway remodelling refers to a wide pattern of patophysiological mechanisms involving smooth muscle cell hyperplasia, increase of activated fibroblasts and myofibroblasts with deposition of extracellular matrix. In asthma, it includes alterations of the epithelial cell layer with goblet cell hyperplasia, thickening of basement membranes, peri-bronchial and peri-broncheolar fibrosis.
