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Intralymphatic allergen-specific immunotherapy: An effective and safe alternative treatment route for pollen-induced allergic rhinitis

Background: Allergen-specific immunotherapy is the only causative treatment of IgE-mediated allergic disorders. The most common administration route is subcutaneous, which may necessitate more than 50 allergen injections during 3 to 5 years. Recent evidence suggests that direct intralymphatic injections could yield faster beneficial results with considerably lower allergen doses and markedly reduc

Hypothalamic Involvement Predicts Cognitive Performance and Psychosocial Health in Long-term Survivors of Childhood Craniopharyngioma

Context: Hypothalamic damage caused by craniopharyngioma (CP) is associated with poor functional outcome. Objective: To assess cognitive function and quality of life in childhood-onset CP on hormonal replacement, including GH treatment. Design: A cross-sectional study with a median follow-up time of 20 years (1-40). Setting: Patients were recruited from the South Medical Region of Sweden. Particip

Formation and consumption of NO in H-2 + O-2 + N-2 flames doped with NO or NH3 at atmospheric pressure

Flat premixed burner-stabilized H-2 + O-2 + N-2 flames, neat or doped with 300-1000 ppm of NO or NH3, were studied experimentally using molecular-beam mass-spectrometry and simulated numerically. Spatial profiles of temperature and concentrations of stable species, H-2, O-2, H2O, NO, NH3, and of H and OH radicals obtained at atmospheric pressure in lean (phi = 0.47), near-stoichiometric (phi = 1.1

Speech is Silver; Silence is Golden

This paper experimentally investigates free-riding behavior on communication cost in a coordination game and finds strong indications of such free-riding. Firstly,the subjects wait for others to send a message when communication is costly, which does not happen when communication is costless. Secondly, the proportion of games where no communication or one-way communication takes place is much high

Evaluating national guidelines for the prophylactic treatment of respiratory syncytial virus in children with congenital heart disease

Aim: This is the first study to evaluate compliance with the 2003 Swedish national guidelines for prophylactic treatment of respiratory syncytial virus (RSV) in children with congenital heart disease (CHD). We estimated the relative risk (RR) of children with CHD being hospitalised with a RSV infection, studied the extent to which RSV prophylactic treatment with palivizumab corresponded to the gui

The Nordic medical birth registers - a potential goldmine for clinical research

The Nordic medical birth registers have long been used for valuable clinical research. Their collection of data for more than four decades offers unusual possibilities for research across generations. At the same time, serum and blotting paper blood samples have been stored from most neonates. Two large cohorts (approximately 100000 births) in Denmark and Norway have been described by questionnair

Dynamic systems in semiotic development: The transition to reference

Semiotic development involves the development of at least two different kinds of meaning: intersubjective and representational. By attending to these two kinds of meaning we are able to predict one of the major transitions in early childhood: the transition to reference. From a dynamic systems perspective we track essential developments which, when all have reached critical values, prompt the tran

On Microstructural Analysis of Porous Media Existing in Fuel Cells Using the Lattice Boltzmann Method

This Licentiate thesis aims to gain understanding related to the fluid behavior in porous media existent in fuel cells (FCs) at microscale. In order to achieve this; the widely used methodology for solving problems in porous media has been applied, the Lattice Boltzmann Method (LBM). LBM presents several advantages to solve problems where the microstructural architecture is complex. The introduc

Medial Temporal Lobe Atrophy Increases the Specificity of Cerebrospinal Fluid Biomarkers in Alzheimer Disease with Minor Cerebrovascular Changes.

Background: Although cerebrospinal fluid (CSF) biomarkers and medial temporal lobe atrophy (MTA) contribute to the diagnosis of Alzheimer disease (AD), they may not be specific. Relatively little is known about how they correlate with each other. Purpose: To identify the validity of the radiological linear measurements of brain atrophy in AD diagnosis by examining the correlation with CSF biomarke

Difficult cannulation as defined by a prospective study of the Scandinavian Association for Digestive Endoscopy (SADE) in 907 ERCPs

Background. The definition of a "difficult" cannulation varies considerably in reports of endoscopic retrograde cholangiopancreatography (ERCP). Aims. To define a difficult cannulation, which translates into higher risk of post-ERCP pancreatitis. Patients and methods. Prospective consecutive recording of 907 cannulations in Scandinavian centers done by experienced endoscopists. Inclusion: indicati

Proxy global assessment of land degradation

Land degradation is always With Lis but its causes, extent and severity are contested. We define land degradation as a long-term decline in ecosystem function and productivity, Which may be assessed using lone-term, remotely sensed normalized difference vegetation index (NDVI) data. Deviation from the norm may serve as a proxy assessment of land degradation and improvement - if other factors that

Electronic Structure of Genomic DNA: A Photoemission and X-ray Absorption Study.

The electronic structure of genomic DNA has been comprehensively characterized by synchrotron-based X-ray absorption and X-ray photoelectron spectroscopy. Both unoccupied and occupied states close to the Fermi level have been unveiled and attributed to particular sites within the DNA structure. A semiconductor-like electronic structure with a band gap of approximately 2.6 eV has been found at whic

Continuous-Time Delta-Sigma Modulators for Ultra-Low-Power Radios

Popular Abstract in Swedish Små, trådlösa och portabla apparater utgör idag en stor del av vår uppkopplade värld. Under det senaste decenniet har dock flera teknologiska framsteg lett mot en utveckling där allt från maskiner till kläder kommunicerar med varandra. Detta brukar kallas för "sakernas internet" och uppskattas involvera 50 miljarder enheter år 2020. Genom att förse dessa enheter med småThe modern small devices of today require cheap low power radio frequency (RF) transceivers that can provide reliable connectivity at all times. In an RF transceiver, the analog-to-digital converter (ADC) is one of the most important parts and it is also one of the main power consumers. There are several architectures for implementing an ADC, but in the last decade, continuous-time Delta-Sigma mod

Discourses of the Heian Era and National Identity Formation in Contemporary Japan

This paper investigates the relationship between history and national identity, specifically how “golden ages” in a nation’s past are used for nationalist ends. Using discourse analysis, it examines how two types of popular historical venues, museums and textbooks, present Japan’s Heian period (794-1185) and explores what this reveals about Japanese national identity formation. The Heian era has a

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts

Objective IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies. Design We conducted a GWA study (GWAS) of IBS in a general population sample of 11 326 Swedish twins. IBS cases (N=534) and asymptomatic controls (N=4932) w

Influence of probe flexibility and gelatin embedding on neuronal density and glial responses to brain implants.

To develop long-term high quality communication between brain and computer, a key issue is how to reduce the adverse foreign body responses. Here, the impact of probe flexibility and gelatine embedding on long-term (6w) tissue responses, was analyzed. Probes of same polymer material, size and shape, flexible mainly in one direction, were implanted in rat cerebral cortex (nimplants = 3 x 8) in two

Quantitative image contrast enhancement in time-gated transillumination of scattering media

Experimental work in turbid media has shown that transillumination images can be significantly improved by limiting light collection to a subset of photons which are minimally distorted by scattering. The literature details numerous schemes (commonly termed ballistic imaging), most often based on time-gating and/or spatially filtering the detected light. However, due to the complex nature of the d