Objective- The Wnt/β-catenin pathway orchestrates development of the blood-brain barrier, but the downstream mechanisms involved at different developmental windows and in different central nervous system (CNS) tissues have remained elusive. Approach and Results- Here, we create a new mouse model allowing spatiotemporal investigations of Wnt/β-catenin signaling by induced overexpression of Axin1, a

The incidence of stroke and dementia are diverging across the world, rising for those in low- and middle-income countries and falling in those in high-income countries. This suggests that whatever factors cause these trends are potentially modifiable. At the population level, neurological disorders as a group account for the largest proportion of disability-adjusted life years globally (10%). Amon

The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously

Background and objectives: The aim of our study is to validate the registration of knee arthroplasty revisions in the Lithuanian Arthroplasty Register (LAR) and thus give an indication of the accuracy of the published revision rates. Materials and methods: A total of 4269 primary total knee arthroplasties (TKAs) registered in the LAR between 2013 and 2015 were included. Two years after surgery the

While dietary factors are important modifiable risk factors for type 2 diabetes (T2D), the causal role of carbohydrate quality in nutrition remains controversial. Dietary glycemic index (GI) and glycemic load (GL) have been examined in relation to the risk of T2D in multiple prospective cohort studies. Previous meta-analyses indicate significant relations but consideration of causality has been mi

BACKGROUND: Several therapies are available for psoriasis, including in some countries oral fumaric acid derivatives (FADs). Even if FADs are not available in the Italian market, they can be prescribed and reimbursed by the National Health Service, on request from the treating physician, when considered as a valuable option in selected patient.METHODS: We performed a retrospective analysis of the

Necrobiosis lipoidica diabeticorum (NLD) is a chronic condition, which is characterized by single or multiple lesions on the legs, and occurs in 0.3% of patients with diabetes. Recently, platelet-rich plasma (PRP) has been used in several clinical settings to promote sustained healing and better outcome. We propose the use of PRP for the treatment of NLD-associated recalcitrant wounds. In this stu

Fat Embolism Syndrome (FES) is a rare and often lethal condition, associated with trauma or surgery. It is more serious than a typical fat embolism seen after a fracture in a long bone. FES is a triad of symtoms, including respiratory failure, abnormal neurology and petechial bleeding. FES is a diagnosis of exclusion. The incidence of FES is higher among adults compared to children. One possible e

Electric vehicles have recently garnered significant attention in the research community due to their potential has a large, highly controllable load which can be used in demand response, load shaping, and renewable energy integration. However, research into practical charging algorithms has been hampered by the lack of a widely available, realistic simulation environment. To meet this need in the

Limits are set on the pair production of scalar leptoquarks, where all possible decays of the leptoquark into a quark (t, b) and a lepton (τ, ν) of the third generation are considered. The limits are presented as a function of the leptoquark mass and the branching ratio into charged leptons for up-type (LQ3 u → tν/bτ) and down-type (LQ3 d → bν/tτ) leptoquarks. Many results are reinterpretations of

This commentary on Wooffitt’s lucid article discusses three major implications of the phenomenon of poetic confluences or ESP puns to our understanding of minds and selves. The first reinforces the view of mind as associative and metaphorical, rather than merely computational. The second reviews various strands of evidence, including experimental research on psi phenomena, to reveal that selves an

The problem of estimating receiver or sender node positions from measured receiver-sender distances is a key issue in different applications such as microphone array calibration, radio antenna array calibration, mapping and positioning using UWB or using round-trip-time measurements between mobile phones and WiFi-units. In this paper we address the problem of optimally estimating a receiver positi

In this paper optimal spectral analysis window shapes, using weighted discrete prolate spheroidal sequences as basis functions, are proposed. These windows are not typically positive or even. The windows are time-shifted, combining the computational efficiency of the Welch method and the appealing property of predefined frequency resolution of the Thomson spectral estimator. The parameters of the

We analyze the sensitivity of hadronic τ decays to nonstandard interactions within the model-independent framework of the standard model effective field theory. Both exclusive and inclusive decays are studied, using the latest lattice data and QCD dispersion relations. We show that there are enough theoretically clean channels to disentangle all the effective couplings contributing to these decays