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Dihydropyrimidinase (DHPase) is a key enzyme in the pyrimidine pathway, the catabolic route for synthesis of β-amino acids. It catalyses the reversible conversion of 5,6-dihydrouracil (DHU) or 5,6-dihydrothymine (DHT) to the corresponding N-carbamoyl-β-amino acids. This enzyme has the potential to be used as a tool in the production of β-amino acids. Here, the reaction mechanism and origin of ster

Purpose: Tensor-valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional diffusion weighting. In this work, we investigate the technical feasibility of tensor-valued diffusion encoding at high b-values with q-space trajectory imaging (QTI) analysis, in the human heart in vivo. Methods: Ten healthy volunteers were scanned on a 3T sca

We explore the regional engagement of universities in non-core regions in a Global South context and uncover how new universities form and institutionalize regional ties. Through case studies of five new universities in India, we identify three routes–personal, organizational and brokered–through which new universities form regional ties, and four logics–incrementalism, social responsibility, legi

Objective: Despite recommendations, assessment using spirometry or peak expiratory flow is insufficient in the clinical evaluation of suspected obstructive pulmonary disease. The aim was to investigate factors associated with performing spirometry or peak flow expiratory flow assessment. Methods: Randomly selected subjects from the general population aged 50–65 completed a respiratory questionnair

Global warming and more frequent climate extremes have caused bark beetle outbreaks of unprecedented scale of these insects in many conifer forests world-wide. Conifers that have been weakened by drought and heat or damaged by storms are highly susceptible to bark beetle infestation. A large proportion of trees with impaired defences provides good conditions for beetle population build-up of beetl

The association between pesticide exposure and non-Hodgkin lymphoma (NHL) including hairy cell leukemia (HCL) was analyzed in a pooled study of three case-control studies. Results on exposure to pesticides were based on 1,425 cases and 2,157 controls participating in the studies. Exposures were assessed by self-administered questionnaires completed as needed by phone. In the pooled univariate anal

PURPOSE: To determine whether β-microseminoprotein or any of the kallikrein forms in blood-free, total or intact PSA or total hK2-predict metastasis in patients with evidence of detectable levels of PSA in blood after radical prostatectomy.METHOD: We determined marker concentrations in blood from 173 men treated with radical prostatectomy and evidence of detectable levels of PSA in the blood (PSA

Introduction: Antineoplastic drugs (ADs) are commonly used pharmaceuticals for anticancer treatments. It has previously been shown that the external surface of drug vials frequently is contaminated with ADs. More than a decade ago methods to prevent occupational exposure were introduced by using plastic coverage of the glass vials or packing vials in a secondary plastic container. The aim of the p

For language learners who aspire to become multilingual, commitment involves a personal journey. Defining persistence as a preoccupation with goal-focused action directed to a desired future state and drawing on research from cognitive psychology and the mental time travel paradigm, this article presents an identity-based framework of persistence in multiple language learning. In the framework, pe

Background: Outcome after colorectal liver metastases (CRLM) resection has improved over time, despite increased resection rates. Hence, it's crucial to identify all patients possible to treat with curative intent. The objectives of this study were to map recurrence pattern, treatment strategy and survival depending on treatment and follow-up strategy. Methods: In the COLOFOL-trial, patients with

Ska allt vi förknippar med den offentliga sfären – tillgång till offentliga miljöer, arbetsliv, sociala relationer – vara tillgängligt för personer med funktionsnedsättning? Knappast någon skulle idag svara ”nej”. Men hur resonerar vi kring den privata sfären, kring frågor om intimitet och sexualitet? Är det möjligt att öka tillgängligheten också till dessa viktiga delar i en människas liv? Och ka

The article gives an overview of Crip Theory, a diverse assembly of critical perspectives on dis/ability, and outlines how it can be used to analyse social relations and intersectionality in contemporary societies. Arguing that Crip Theory is indebted not only to cultural studies but also to materialist models of disability and feminist theory, the authors conclude that it can contribute significa

The paper presents novel studies on the impact of different ignition control parameters on combustion stability and spark plug wear. First, experimental results from a 32.4-liter biogas fueled large bore single cylinder spark ignition engine are discussed. Two different ignition systems were considered in the experiment: a DC inductive and an AC capacitive. The spark plugs used in the experiment w

This contribution is an analysis of the philosophical construction of the dignity of the human, with a critical but hopefully constructive engagement with Dan Egonsson’s reflections on social attitudes about the dignity of humanity and how and why moral philosophers ought to account for then. I agree that philosophers should account for actual social attitudes, but my discussion will tend towards

Unga vuxna nämns ofta som bland de mest ekonomiskt utsatta grupperna och Sverige karakteriseras ofta som ett av de länder i EU som har de mest skuldsatta hushållen. Även om hushållens skuldsättning främst är kopplad till bostadslån, har även andra former av kreditanvändning blivit allt vanligare. Mot bakgrund av en ökande tillgången till lättillgängliga konsumentkrediter, en tuff bostadsmarknad meYoung adults are often mentioned as among the most financially vulnerable groups, and Sweden is often characterized as being one of the countries in the EU with the most indebted households. While this houshold indebtedness mainly is linked to home loans, also other forms of credit usage have become increasingly common. Given the increasing access to readily availabe consumer credits, a difficult