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Phase-synchronous detection of coherent and incoherent nonlinear signals

The nonlinear optical response of a material system contains detailed information about its electronic structure. Standard approaches to nonlinear spectroscopy often use multiple beams crossed in a sample, and detect the wave vector matched polarization in transmission. Here, we apply a phase-synchronous digital detection scheme using an excitation geometry with two phase-modulated collinear ultra

Sense of Touch in Robots with Self-Organizing Maps

We review a number of self-organizing-robot systems that are able to extract features from haptic sensory information. They are all based on self-organizing maps (SOMs). First, we describe a number of systems based on the three-fingered-robot hand, i.e., the Lund University Cognitive Science (LUCS) Haptic-Hand II, that successfully extracts the shapes of objects. These systems explore each object

The role of HOXB2 and HOXB3 in acute myeloid leukemia.

Acute myeloid leukemia (AML) is a heterogeneous aggressive disease and the most common form of adult leukemia. Mutations in the type III receptor tyrosine kinase FLT3 are found in more than 30% of patients. Drugs against FLT3 have been developed for the treatment of AML, but they lack specificity, show poor response and lead to the development of a resistant phenotype upon treatment. Therefore, a

Scanning gate imaging of quantum dots in 1D ultra-thin InAs/InP nanowires

We use a scanning gate microscope (SGM) to characterize one-dimensional ultra-thin (diameter approximate to 30 nm) InAs/InP heterostructure nanowires containing a nominally 300 nm long InAs quantum dot defined by two InP tunnel barriers. Measurements of Coulomb blockade conductance versus backgate voltage with no tip present are difficult to decipher. Using the SGM tip as a charged movable gate, w

Classification, epidemiology and clinical subgrouping of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.

It is now 25 years since the first European studies on vasculitis-the anti-neutrophil cytoplasmic antibody (ANCA) standardization project. Over that period of time, there have been major developments in the classification of the vasculitides, which has permitted the conduct of high-quality epidemiology studies. Studying the epidemiology of rare diseases such as the ANCA-associated vasculitides (AA

Effects of fuel cetane number on the structure of diesel spray combustion: An accelerated Eulerian stochastic fields method

An Eulerian stochastic fields (ESF) method accelerated with the chemistry coordinate mapping (CCM) approach for modelling spray combustion is formulated, and applied to model diesel combustion in a constant volume vessel. In ESF-CCM, the thermodynamic states of the discretised stochastic fields are mapped into a low-dimensional phase space. Integration of the chemical stiff ODEs is performed in th

Stable Cation Inversion at the MgAl2O4(100) Surface

From an interplay of atom-resolved noncontact atomic force microscopy, surface x-ray diffraction experiments, and density functional theory calculations, we reveal the detailed atomic-scale structure of the (100) surface of an insulating ternary metal oxide, MgAl2O4 (spinel). We surprisingly find that the MgAl2O4(100) surface is terminated by an Al and O-rich structure with a thermodynamically fav

Transverse resonant properties of strained gold nanowires

In this work, resonant and elastic properties of single crystal gold nanowires have been studied through classical molecular dynamics simulations. The considered nanowires have perfect square cross sections and are oriented with the [100] direction along the wire axis and with {100} side surfaces. Three different sizes were simulated; 4.08×4.08 nm2, 5.71×5.71 nm2, and 7.34×7.34 nm2 cross sectional

Rituximab for the treatment of eosinophilic granulomatosis with polyangiitis (Churg-Strauss).

Conventional treatment of eosinophilic granulomatosis with polyangiitis (EGPA) (Churg-Strauss) with glucocorticoids, with or without additional immunosuppressive drugs, is limited by partial efficacy, frequent toxicity and a high relapse rate. Rituximab is a licensed treatment for granulomatosis with polyangiitis and microscopic polyangiitis and is of potential benefit to patients with EGPA.

Maxillary sinus augmentation with iliac autograft - a health-economic analysis.

PURPOSE: To estimate and compare the costs of maxillary sinus augmentation performed with autologous bone graft either from the iliac crest or from local bone harvested from the mandibula. To evaluate post-operative health-related quality-of-life parameters for patients subjected to sinus augmentation and iliac bone surgery. MATERIAL AND METHODS: The hospital records of 14 patients subjected to si

Obstetric outcome after in vitro fertilization with single or double embryo transfer

BACKGROUND: IVF children, including singletons, are known to have a poorer obstetric outcome than children born after spontaneous conception. With a broad introduction of single embryo transfer (SET), this scenario might change. This study compares the obstetric outcome after IVF with SET, elective SET (eSET), non elective SET (non-eSET) and double embryo transfer (DET) with outcomes in the genera

Mutations in TP53 tumor suppressor gene in wood dust-related sinonasal cancer

The causal role of work-related exposure to wood dust in the development of sinonasal cancer has long been established by numerous epidemiologic studies. To study molecular changes in these tumors, we analyzed TP53 gene mutations in 358 sinonasal cancer cases with or without occupational exposure to wood dust, using capillary electrophoresis single-strand conformation polymorphism analysis and dir

The importance of adequate stem anteversion for rotational stability in cemented total hip replacement: A radiostereometric study with ten-year follow-up.

Progressive retroversion of a cemented stem is predictive of early loosening and failure. We assessed the relationship between direct post-operative stem anteversion, measured with CT, and the resulting rotational stability, measured with repeated radiostereometric analysis over ten years. The study comprised 60 cemented total hip replacements using one of two types of matt collared stem with a ro

Molecular Architecture of the Goodpasture Autoantigen in Anti-GBM Nephritis

BACKGROUND In Goodpasture's disease, circulating autoantibodies bind to the noncollagenous-1 (NC1) domain of type IV collagen in the glomerular basement membrane (GBM). The specificity and molecular architecture of epitopes of tissue-bound autoantibodies are unknown. Alport's post-transplantation nephritis, which is mediated by allo-antibodies against the GBM, occurs after kidney transplantation i

Search for direct third-generation squark pair production in final states with missing transverse momentum and two b-jets in root s=8 TeV pp collisions with the ATLAS detector

The results of a search for pair production of supersymmetric partners of the Standard Model third-generation quarks are reported. This search uses 20.1 fb(-1) of pp collisions at root s = 8 TeV collected by the ATLAS experiment at the Large Hadron Collider. The lightest bottom and top squarks ((b) over tilde (1) and (t) over tilde (1) respectively) are searched for in a final state with large mis

Theoretical investigation of magnetic-field-induced 2p(5)3s 3P(0,2)-2p(6) S-1(0) transitions in Ne-like ions without nuclear spin

We report theoretical results for magnetic-field-induced 2p(5)3s 3P(0,2)-2p(6) S-1(0) E1 transitions in Ne-like ions with zero nuclear spin (I = 0) between Mg III and Zn XXI as well as in Ne I. We demonstrate that it is important to include both "perturber" states 2p(5)3s P-1(1) and 2p(5)3s P-3(1) in order to produce reliable transition rates. Furthermore, we investigate the trends of the rates al

Patient-Reported Outcome Measures and Risk Factors in a Quality Registry: A Basis for More Patient-Centered Diabetes Care in Sweden

Diabetes is one of the chronic diseases that constitute the greatest disease burden in the world. The Swedish National Diabetes Register is an essential part of the diabetes care system. Currently it mainly records clinical outcomes, but here we describe how it has started to collect patient-reported outcome measures, complementing the standard registry data on clinical outcomes as a basis for eva

Soil food web properties explain ecosystem services across European land use systems

Intensive land use reduces the diversity and abundance of many soil biota, with consequences for the processes that they govern and the ecosystem services that these processes underpin. Relationships between soil biota and ecosystem processes have mostly been found in laboratory experiments and rarely are found in the field. Here, we quantified, across four countries of contrasting climatic and so

Perceived and anticipated discrimination in people with mental illness-An interview study.

Background. Studies on perceived discrimination of people with mental illness are largely lacking. The purpose of the study was to investigate perceived discrimination in a sample of users in contact with mental health services in Sweden. Methods. Interviews were conducted with 156 users, asking for perceived and anticipated discrimination during the last 2 years. Background characteristics were a