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During regulation of blood glucose levels, various hormones interact and counteract with each other in a complex manner. Together, these hormones maintain stable glucose levels. The recent mapping of hormonal interactions, carried out by scientists at Lund University Diabetes Centre (LUDC), aimed to explain why an imbalance occurs and to increase our understanding of the causes of diabetes. Insuli

https://www.ludc.lu.se/article/stable-glucose-levels-are-result-complex-hormonal-balancing-act - 2025-10-05

For the first time, scientists are able to describe the exact mechanism for how a common genetic variant leads to a disruption in blood lipid levels that significantly increases the risk of heart disease. The one in every three persons who carries both copies of the risk allele engages a 40 percent higher risk of suffering a heart attack than persons who do not carry either copy of the risk allele

https://www.ludc.lu.se/article/mechanism-behind-common-heart-attack-gene-explained-scientific-breakthrough-nature - 2025-10-05

As a PhD student he made a significant discovery when he identified ghrelin cells in the pancreatic islands. Four hormone-producing cells were already known to exist in the islands, including the insulin cell. The ghrelin cell became the fifth such cell. “In the scientific world, the discovery of a new type of cell in a human organ is a big deal. So naturally this was an important find. Especially

https://www.ludc.lu.se/article/flying-start-fifth-cell - 2025-10-05

In competition with more than a thousand entries for the Presidential Poster Competition at the 2010 Endocrine Society congress in San Diego, USA, the winning contribution was that of Rajesh Kumar, scientist at Lund University Diabetes Centre. The research in question relates to the positive effects of the oestrogen hormone on the survival rates of insulin cells. Rajesh Kumar’s summary of the ongo

https://www.ludc.lu.se/article/oestrogen-protects-transplanted-cells-and-organs - 2025-10-05

The goal is set high, that during the coming ten years develop new methods to prevent, cure and treat diabetes. - Ambitious, but not unrealistic, says Leif Groop, coordinator for EXODIAB, the joint research project that Lund and Uppsala now will launch with a conference in Malmö September 9-10th. Wide range and conductingEXODIAB (Excellence Of Diabetes Research in Sweden) is one of the governments

https://www.ludc.lu.se/article/kick-large-venture-diabetes-research - 2025-10-05

Marju Orho-Melander, professor of genetic epidemiology in Malmö, has been awarded Lund University’s Fernström prize. Her research is about genetic variants that are associated with blood lipids and lipoproteins and can therefore increase the risk of cardiovascular disease. Many genes exist in different variants. Sometimes, some of the variants have a negative effect, in particular if they are comb

https://www.ludc.lu.se/article/lunds-fernstrom-prize-goes-research-genes - 2025-10-05

Leif Groop, professor in diabetes and endocrinology at Lund University Diabetes Centre and consultant at the Endocrinological Department at Skåne University Hospital Malmö, has been elected to the diabetologist of the year by the Swedish Society of Diabetology. - I am of course honored and happy that my work is appreciated, comments Leif Groop.In the motivation for the appointment his focus to ide

https://www.ludc.lu.se/article/leif-groop-diabetologist-year-2010 - 2025-10-05

An extensive global gene-mapping project has identified a large number of loci that dictate whether a person is tall or short. The aim of the project is to find out more about how many genes interact to form biologically interesting mechanisms behind diseases. "Height on its own is perhaps not tremendously interesting but it serves as a good indicator when determining how genetic mechanisms work",

https://www.ludc.lu.se/article/height-study-casts-light-genetic-mechanisms - 2025-10-05

TrialNet studies are now starting in Sweden, with the initial trials in Skåne. TrialNet is an international network of researchers who are investigating possible ways to prevent, delay and reverse the development of type 1 diabetes. The TrialNet network is currently made up of 18 research centres – in the USA, Canada, Finland, Sweden, the United Kingdom, Italy, Germany, Australia and New Zealand.

https://www.ludc.lu.se/article/are-you-related-someone-type-1-diabetes - 2025-10-05

Research groups in close collaboration in Malmö have shed light on the pathway whereby a common genetic risk variant leads to impaired mitochondrial function of insulin cells. The variant in question impairs the capacity to secrete insulin and increases the risk of developing diabetes. The discovery is published in the highly ranked scientific journal Cell Metabolism. It is widely established that

https://www.ludc.lu.se/article/disturbance-cellular-power-plant-increases-risk-diabetes - 2025-10-05

Researchers are now asking the question the other way around. They want to know why some diabetic patients do not develop complications. What is protecting them? The PROLONG study may provide the answer. - The majority of diabetics will over time develop severe or lethal complications, but 10-15 percent never do. They are the ones we are interested in the PROLONG study, explains Valeriya Lyssenko

https://www.ludc.lu.se/article/why-are-some-diabetics-free-complications - 2025-10-05

The professors Patrik Brundin and Leif Groop have from the European Research Council (ERC) been awarded the Advanced Grant for 2010. The Advanced Grants are awarded to support excellent and innovative research performed or led by established and wold leading research leaders.Leif Groop researches about genetic causes to Type 2 Diabetes. The project for which he receivs the award for is called "Gen

https://www.ludc.lu.se/article/two-world-leading-researchers-receivs-erc-advanced-grant - 2025-10-05

Type 2 Diabetes is the fastest growing disease in the world of today. The cause is that we are not biologically adapted to our way of living. The highest increase of diabetes occurs in countries where the living standards increases very fast. Only 20 years ago the disease was almost unknown in the developing countries. Today it is very common, only in China nearly 100 millions suffers from diabete

https://www.ludc.lu.se/article/collision-between-genes-and-life-style - 2025-10-05

DPP-4 inhibitors are a group of drugs used to treat type 1 diabetes that lower high blood usgar levels by stimulating insulin production in the body. Researchers at Lund University in Sweden have now discovered that DPP-4 inhibitors are also effective against low blood sugar levels. The study, which was carried out on mice, has been published in the journal Diabetologia. “If these inhibitors also

https://www.ludc.lu.se/article/diabetes-drug-could-protect-against-low-blood-sugar - 2025-10-05

Charlotte Ling, researcher at Lund University Diabetes Centre, receives this year´s Novo Nordisk Foundation Excellence Project grant, five millions Danish crowns allocated during five years. Her project is about exploring whether epigenetic factors are underlying the development of Type 2 Diabetes. - This means very much to me and my research group. We will be able to expand and it will speed up t

https://www.ludc.lu.se/article/large-grant-exporing-epigenetics-diabetes - 2025-10-05

No one can explain this strange phenomenon. The majority of type 2 diabetics who undergo metabolic surgery recover from diabetes only a few days after the procedure, long before any weight loss has occurred. Now researchers at Lund University Diabetes Centre plan to find out what is happening by studying both patients and pigs before and after metabolic surgery. - Since the recovery from diabetes

https://www.ludc.lu.se/article/how-can-metabolic-surgery-cure-diabetes-so-fast - 2025-10-05

Sofia Enhörning is the younger researcher in Scandinavia who wrote the best scientific article of the year within diabetes research. This means the Scandinavian Society for the Study of Diabetes (SSSD) which gives away the prize to her at the recent congress in Reykjavik.  - Really positive. And an acknowledgement that we have discovered something that others also find important, says Sofia Enhörn

https://www.ludc.lu.se/article/prize-best-scientific-article-scandinavia - 2025-10-05

Despite the disappointing results in trying to treat children suffering from type 1 diabetes with the GAD vaccine, the treatment has not been written off entirely. DIAPREV-IT, the study in which healthy high-risk children are vaccinated, is continuing as planned, and now with more money behind it. "I am still hopeful that the GAC vaccine will work", says Helena Elding Larsson. Dr Elding Larsson is

https://www.ludc.lu.se/article/still-hope-gad-diabetes-vaccine - 2025-10-05

Professor Olle Melander at Lund University Diabetes Centre and Skåne University Hospital in Malmö recieves Heart- and Lung Foundation´s large grant of 15 millions swedish crowns. By investigating the genome in tens of thousands has Olle Melander succeeded to identify markers in the blood which increase the risk of suffering from cardiovascular diseases. The next step is to investigate the markers

https://www.ludc.lu.se/article/heart-research-recieves-15-millions-swedish-crowns - 2025-10-05

The fact that diabetes rases the risk of certain types of cancer is already well known, but the reasons have been unclear. Now researchers at Lund University in Sweden have mapped a molecular link that explains the connection between the two widespread diseases. Developing type 2 diabetes is a lengthy process. An early sign that it has begun is high levels of insulin in the blood. As long as the i

https://www.ludc.lu.se/article/molecular-link-between-diabetes-and-cancer-described - 2025-10-05