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Evidence for dysfunction of the nigrostriatal pathway in the R6/1 line of transgenic Huntington's disease mice

Petersén Å, Puschban Z, Lotharius J, NicNiocaill B, Wiekop B, O´Connor, WT and Brundin P.Neurobiology of Disease 11: 134-146 (2002)AbstractThe present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxy

https://www.huntington-research.lu.se/evidence-dysfunction-nigrostriatal-pathway-r61-line-transgenic-huntingtons-disease-mice - 2026-05-25

Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease

Petersén Å, Chase K, Puschban Z, DiFiglia M, Brundin P and Aronin N.Experimental Neurology 175: 297-300 (2002)AbstractA transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with

https://www.huntington-research.lu.se/maintenance-susceptibility-neurodegeneration-following-intrastriatal-injections-quinolinic-acid-new - 2026-05-25

Huntington's Disease: the mystery unfolds?

Petersén Å and Brundin P.International Review of Neurobiology 53: 315-339 (2002) SummaryThe Huntington's disease (HD) has stimulated novel clinical drug trials based on the ideas about mechanisms of cell death in the disorder. A recent study investigated the effects of remacemide and coenzyme Q on progression of symptoms in HD. These drugs are an N-methyl-d-aspartate (NMDA) antagonist and a mitoch

https://www.huntington-research.lu.se/huntingtons-disease-mystery-unfolds - 2026-05-25

Mice transgenic for exon 1 of the Huntington's disease gene display reduced striatal sensitivity to neurotoxicity induced by dopamine and 6-hydroxydopamine

Petersén Å, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S and Brundin P.European Journal of Neuroscience 14: 1-13 (2001)AbstractHuntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease. We have

https://www.huntington-research.lu.se/mice-transgenic-exon-1-huntingtons-disease-gene-display-reduced-striatal-sensitivity-neurotoxicity - 2026-05-25

Expanded CAG repeats in exon 1 of the Huntington's Disease gene stimulate dopamine-mediated striatal neuron autophagy and degeneration

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P and Sulzer D.Human Molecular Genetics 10: 1243-1254 (2001)AbstractHuntington's disease (HD) is caused by an expanded CAG repeat in exon 1 of the gene coding for the huntingtin protein. The cellular pathway by which this mutation induces HD remains unknown, although alterations in protein degradation are involved. To study intrinsic

https://www.huntington-research.lu.se/expanded-cag-repeats-exon-1-huntingtons-disease-gene-stimulate-dopamine-mediated-striatal-neuron - 2026-05-25

Brain-derived neurotrophic factor inhibits apoptosis and dopamine-induced free radical production in striatal neurons but does not prevent cell death

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, and Sulzer D.Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Lund, SwedenBrain Research Bulletin 56(3-4): 331-335 (2001)AbstractIn hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) p

https://www.huntington-research.lu.se/brain-derived-neurotrophic-factor-inhibits-apoptosis-and-dopamine-induced-free-radical-production - 2026-05-25

The Collection

The books in the Library of the Law Commissions have belonged to various committees that worked on reforms of Swedish legislation. Presented here is a brief history and timeline of the committees. The book collection comes primarily from a series of committees and commissions that worked to reform Swedish legislation during the period 1811-1974. In parallel with these, there were other committees,

https://www.law.lu.se/library/library-swedish-law-commissions/collection - 2026-05-25

Climate Adaptation and Human Rights – 5 credits

Climate Adaptation and Human Rights (JXCA01) – Distance Course in English Climate change affects societies, ecosystems, and people’s living conditions across the globe. Addressing growing risks such as floods, heatwaves, droughts, and other climate-related disasters requires not only technical solutions, but also socially just and inclusive strategies. This online course in Climate Adaptation and

https://www.law.lu.se/study/x-courses/climate-adaptation-and-human-rights-5-credits - 2026-05-25

Summer School in Digital Human Rights (Closed for application)

Intensive course taught by leading experts in the field The Faculty of Law and the Raoul Wallenberg Institute for Human Rights at the University of Lund are delighted to announce a Summer School in Digital Human Rights, which will take place in Lund, Sweden from 22-26 June 2026. This will be a residential, advanced, and intensive course on the application of international human rights law in the d

https://www.law.lu.se/study/summer-school-digital-human-rights-closed-application - 2026-05-25

Climate Effects under the EIA Directive

4 June 2026 10:15 | Seminar Screening for Sustainability seminar - “Climate Effects under the EIA Directive”Benoit Mayer, Professor of Climate Law at the School of Law at the University of Reading.Climate Effects under the EIA DirectiveThe EU Environmental Impact Assessment (EIA) Directive was amended in 2014 to require developers to assess the significant direct and indirect effects of their proj

https://www.law.lu.se/calendar/climate-effects-under-eia-directive - 2026-05-25

Graduation ceremony for the Master’s programmes

5 June 2026 10:00 to 13:00 | Other Graduation ceremony for the Master’s programmes in International Human Rights Law and European Business Law. Graduating students from the Master’s programmes in International Human Rights Law and European Business Law are warmly invited to attend the upcoming graduation ceremony on 5 June.The event celebrates the accomplishments of our graduating class and marks

https://www.law.lu.se/calendar/graduation-ceremony-masters-programmes-0 - 2026-05-25

Lunch-to-Lunch LU4Water Legal Workshop on Water Regulation

4 June 2026 12:00 to 5 June 2026 13:30 | Workshop Lunch-to-Lunch LU4Water Legal Workshop on Water RegulationFaculty of Law, Lund University, June 4–5, 2026ProgramThursday 4 JuneAddress: Lilla Gråbrödersgatan 3C, Tryckeriet, 3 floor, room Tetra Pak12.00–13.00 Lunch and registration  13.00–13.10 Opening speech        Britta Sjöstedt, Faculty of Law, Lund University        Anna Zemskova, Faculty of L

https://www.law.lu.se/calendar/lunch-lunch-lu4water-legal-workshop-water-regulation - 2026-05-25

Transcription services

At the Faculty of Law, you as a researcher have access to two transcription services: one local service and one that you can use remotely. The Faculty of Law’s Transcription ServiceThe Faculty of Law’s IT department offers a free transcription service. It consists of a local installation of Whisper AI, which allows you to easily transcribe audio files into a text document that is saved directly to

https://www.law.lu.se/transcription - 2026-05-25

Seminar with Romain Francois R Chuffart

29 May 2026 10:15 to 12:00 | Seminar Screening for Sustainability Seminars Romain Francois R ChuffartThis article investigates the colonial legal repetitions that emerge as autonomous shipping vessels are deployed in the Arctic region. Through examining the extractive component of autonomous shipping, we uncover how autonomous shipping operations contribute to an “Othering” and reification of the

https://www.law.lu.se/calendar/seminar-romain-francois-r-chuffart - 2026-05-25

Seminar with Dr Yoriko Otomo

2 June 2026 10:15 to 12:00 | Seminar Screening for Sustainability Seminars: “AI and Implications for Environmental Governance”Dr Yoriko OtomoAI’s environmental harms are not incidental side effects but expressions of a deeply unequal global political economy. Recent projections suggest that data centres’ electricity demand will more than double from about 415 TWh in 2024 to roughly 945 TWh by 2030

https://www.law.lu.se/calendar/seminar-dr-yoriko-otomo - 2026-05-25

Gender Equality and Equal Opportunities Committee

The Gender Equality and Equal Opportunities Committee is a preparatory body for the Faculty Board and Dean with the following tasks:The committee shall propose and initiate various measures for gender equality, diversity and equal treatment to counteract all forms of discrimination.The committee shall conduct an active preventive and systematic work with work environment, gender equality and equal

https://www.law.lu.se/about-faculty/organisation/gender-equality-and-equal-opportunities-committee - 2026-05-25

Guest Lecture with Cathérine Van de Graaf

3 June 2026 14:00 to 15:00 | Lecture/talk Allegation-Picking of Non-Discrimination as Judicial Avoidance?Article 14 as the Fifth Wheel on the Strasbourg Wagon Guest Lecture with Cathérine Van de GraafHuman Rights Center, Ghent UniversityUniversity of Cologne, Academy for European Human Rights ProtectionArticle 14 of the European Convention on Human Rights (ECHR) requires that the rights and freedo

https://www.law.lu.se/calendar/guest-lecture-catherine-van-de-graaf - 2026-05-25

Summer fika with the Health Law Research Centre

26 May 2026 14:30 to 16:00 | Other We, at the Health Law Research Centre, want to wish you all a wonderful and relaxing summer!  May 26 at 2.30 pm, the Health Law Research Centre will organize a very informal summer fika in the Galleria, and you are welcome to join us! There you will meet Mary Donnelly, Professor of Law at University College Cork, and Anne-Maree Farrell, Professor of Medical Juris

https://www.law.lu.se/calendar/summer-fika-health-law-research-centre - 2026-05-25

Guest lecture with Dr. Tamas Molnar

27 May 2026 13:00 to 15:00 | Lecture/talk Guest lecture with Dr. Tamas MolnarThe Role of the EU Agency for Fundamental Rights in the European Fundamental Rights Protection LandscapeDr. Tamas Molnar holds a PhD in public international law (ELTE, Budapest – summa cum laude; title of dissertation: “Incorporation of international legal norms into the Hungarian legal system”).Since September 2016, he h

https://www.law.lu.se/calendar/guest-lecture-dr-tamas-molnar - 2026-05-25

Library Committee

The Library Committee serves as a reference for the library's activities and in selection of information resources. The Committee is an advisory body to the head of department and the head of the library in various library issues. Chair Christoffer Wong Senior Lecturer Email: christoffer [dot] wong [at] jur [dot] lu [dot] se Telephone: +46 46 222 10 38 More information about Christoffer Wong Staff

https://www.law.lu.se/about-faculty/organisation/library-committee - 2026-05-25