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Our Biophysical ToolsOur research group investigates mechanics of viral replication, virus-host interactions, virus assembly and disassembly within the host. Specifically, we investigate energetics, structure and mobility of the intra-capsid genome as well as mechanical properties of viral capsids, influenced by changes in physiological environment that are important for viral replication. Main to
https://www.virus-biophysics.lu.se/methods-and-techniques - 2026-05-03
Principal Investigator: Alex Evilevitch, PhDProfessor of Cell Biology Email: Alex [dot] Evilevitch [at] med [dot] lu [dot] se Lab photos Postdocs José Ramón Villanueva Valencia, PhDEmail: jose_ramon [dot] villanueva-valencia [at] med [dot] lu [dot] se (jose_ramon[dot]villanueva-valencia[at]med[dot]lu[dot]se) Santosh Gawali, PhD Email: santosh [dot] gawali [at] med [dot] lu [dot] se G
https://www.virus-biophysics.lu.se/people - 2026-05-03
Alex Evilevitch Research Group We are always interested in reviewing applications from MSc students, prospective PhD students and postdocs.Project description Herpesviruses are a leading cause of human viral disease. Herpesviruses consist of a double-stranded DNA genome contained within a protein shell, termed the capsid, that is surrounded by an unstructured protein layer and a lipid-envelope. H
https://www.virus-biophysics.lu.se/open-positions - 2026-05-03
https://www.virus-biophysics.lu.se/teaching - 2026-05-03
January 9, 2024 , Physics World "Viruses change structure at the temperature of the human body to better infect us". https://physicsworld.com/a/viruses-change-structure-at-the-temperature-of-the-human-body-to-better-infect-us/ November 8, 2023, Lund University press release on our pioneering study published in PNAS showing how temperature triggers release of viral genome by changing the form and
https://www.virus-biophysics.lu.se/news-0 - 2026-05-03
To see Prof. Alex Evilevitch Open Researcher and Contributor ID (ORCID), click the link below (it opens another website):https://orcid.org/0000-0002-0245-9574 Below, there is the full list of publication of Prof. Alex Evilevitch. It links to another webpage related to the publisher.Villanueva Valencia J. R., Li D., Casjens S. R., Evilevitch A., "‘SAXS-osmometer’ method provides measurement of
https://www.virus-biophysics.lu.se/publications - 2026-05-03
We use atomic force microscopy (AFM) nano-indentation method to measure DNA mobility in the capsid. The mobility of DNA packaged inside the HSV-1 capsid is measured by recording the force resisting the capsid indentation when the AFM tip is brought into contact with the DNA-filled capsid in solution. Force resisting the AFM tip indentation of the capsid is recorded as the force-distance curve. Cap
https://www.virus-biophysics.lu.se/methods-and-techniques/atomic-force-microscopy - 2026-05-03
We use cryo electron microscopy (cryo-EM) and image reconstruction to examine the virion structure at subnanometer resolution. We also analyze structure and density of viral DNA packaged in a capsid. Figure: Cutaway views from cryo-EM reconstructions of (A) HSV-1 C-capsid and (B) phage lambda procapsid and mature DNA-filled lambda capsid. HSV-1 and lambda phage capsids are shown to scale. Owing t
https://www.virus-biophysics.lu.se/methods-and-techniques/cryo-electron-microscopy - 2026-05-03
The isothermal titration calorimetry (ITC) provides the most direct method to measure the internal energy of the confined viral genome. In order to experimentally dissect the thermodynamic determinants of viral DNA packaging and ejection energetics, we were first to use ITC to directly measure the heat released by DNA ejection from a virus capsid. This approach allows one to address experimentally
https://www.virus-biophysics.lu.se/methods-and-techniques/microcalorimetry - 2026-05-03
Super-Resolution Structured Illumination Microscopy (SR-SIM) provides resolutions down to 120 nm, allowing visualization of individual herpesvirus capsids (HSV-1) attached to the nucleus (HSV-1 C-capsid diameter is 125 nm). Figure: Imaging of reconstituted capsid-nuclei system confirms specific capsid binding to the NPCs at the nuclear membrane. Representative super-resolution SIM image showing G
Despite the structure of packaged viral DNA being central for ejection and consequentially infectivity of the virus, the detailed understanding of the packing structure of DNA inside the viral capsid. SAXS and SANS allow investigation of the structure of DNA filled capsids in solution in a wide range of environmental conditions. SAXS and SANS are powerful techniques that provides detailed structur
For many double stranded (ds) DNA viruses the viral genome is actively packaged into the virus capsid by a powerful molecular motor. This results in an energetically unfavorable state of the packaged genome, creating tens of atmospheres internal pressure inside the virion. Using a new calorimetric assay to determine the activation energy barriers associated with genome loss in response to elevated
https://www.virus-biophysics.lu.se/covers-highlights - 2026-05-03
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https://www.arkitektur.lth.se/a-huset/kontakt - 2026-05-03
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https://www.arkitektur.lth.se/a-huset/om-nagot-hander - 2026-05-03
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Welcome to Lund University Pre-Pilot Plant LUPPP - Lund University Pre-Pilot Plant is a cutting-edge research infrastructure designed to accelerate the green transition and strengthen innovation in food technology, biotechnology, and chemical engineering. LUPPP is connected to Biotech Heights and provides a unique environment for the scaling up of bioprocesses from lab to pilot scale. We welcom
https://www.luppp.lu.se/start - 2026-05-03
Purification/chromatography ÄKTA Avant 25 (Cytiva) The ÄKTA Avant 25 is a high-performance liquid chromatography system developed by Cytiva for method and process development in protein purification. It is designed to support a wide range of chromatography techniques including:Affinity chromatographyIon exchange chromatographySize exclusion (gel filtration) chromatographyHydrophobic interaction ch
https://www.luppp.lu.se/resources/biotechnology - 2026-05-03
