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Anxiety is an aggravating comorbidity of many psychiatric disorders that is often underdiagnosed and undertreated, and little is known on the mechanisms underlying its regulation. Here, we find that serum LPA16:0 abundance increases with trait anxiety in both humans and mice; while high LPA16:0 levels are sufficient to reduce the in vitro proliferation of adult hippocampal neural stem/progenitor c
The existence and functional significance of immature neurons in the adult human brain, particularly in the context of neurodegenerative disorders, remain an open question. Although rodent studies have highlighted active roles for adult-born immature neurons in the hippocampus both under healthy conditions and in Alzheimer's disease (AD), evidence from the human brain is limited and lacks detailed
One of the starting points of this work was the duality of Borcea relating standard level k representations of A(1) 1 and level 2k+1 of A(2) 2 . For k = 1, the combinatorial bases in both cases yield the two Capparelli identities and we wanted to see if there is a correspondence between the bases in terms of partitions for all k ∈ N. By using the vertex operator relations in the principal picture
Let (X, T, µ, d) be a metric measure-preserving system for which 3-fold correlations decay exponentially for Lipschitz continuous observables. Suppose that (Mk) is a sequence satisfying some weak decay conditions and suppose there exist open balls Bk (x) around x such that µ(Bk (x)) = Mk. Under a short return time assumption, we prove a strong Borel–Cantelli lemma, including an error term, for rec
Spaceports are a new and often controversial feature of the tourism landscape. This study examines how sustainable development and Environmental, Social, and Governance (ESG) factors impact residents’ quality-of-life (QoL) and support for new spaceport development in South Korea through an integrated theoretical framework combining bottom-up spillover effect theory and process theory. Using a mixe
Positive systems describing networks with inherently non-negative states and inputs arise naturally in routing, logistics, and compartmental modelling. We consider problems modelled as positive linear systems in incidence form with linear cost. The addition of capacity constraints on states (storage) and inputs (flows between nodes) significantly increases the problem complexity. Leveraging the an
We give upper and lower bounds for weighted Chebyshev and residual polynomials on subsets of the real line. As an application, we prove a Szegő-type theorem in the setting of Parreau–Widom sets.
While surface modifications are widely pursued to improve antimicrobial performance of photocatalytic nanoparticles (NPs), the particle–membrane interactions responsible for these effects remain underexplored. We address this gap by investigating the influence of coating TiO2 NPs with the cationic polymer poly(2-(dimethylamino)ethyl methacrylate) methyl chloride quaternary salt (qPDMAEMA). In cont
Background and purpose: Synthetic computed tomography (sCT) enables magnetic resonance imaging (MRI)-only radiotherapy by providing electron density information for dose calculation. While sCT-based planning has been proven sufficiently accurate for convolution-based dose calculation algorithms, linear Boltzmann transport equation (LBTE)-based approaches exhibit higher sensitivity to tissue hetero
To describe the impact of adding a tyrosine kinase inhibitor (TKI) to intensive chemotherapy (IC) on the outcome of de novo BCR::ABL1+ acute myeloid leukemia (AML), we retrospectively analyzed the data of 212 adult AML with ≥20% bone marrow blasts, BCR::ABL1+ or t(9;22)(q34.1;q11.2), no history of previous chronic myeloid leukemia and no prior exposure to BCR-ABL1 TKI. Eighty-nine patients were tr
Blood-based biomarkers are emerging as scalable tools for the diagnosis and monitoring of neurodegenerative diseases, but markers enabling differential diagnosis across major dementias remain limited. Here we show that large-scale plasma proteomics identifies disease-associated signatures across Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia. We analyzed 1,318 plasma sa
Ultrasound-induced degradation of soft polymeric colloids, like microgels, as well as a controlled drug release enabled by mechanoresponsive bonds, has recently attracted considerable attention. However, most examples in the literature focus primarily on the applications rather than examining the underlying mechanisms of the structural changes occurring in microgels due to cavitation─changes that
We propose a network behavioral-feedback Susceptible–Infected–Recovered (SIR) epidemic model in which the interaction matrix describing the infection rates across subpopulations depends in feedback on the current epidemic state. This model captures both heterogeneities in individuals’ mixing, contact frequency, aptitude to contract and spread the infection, and endogenous behavioral responses such
Background: Iron deficiency is a common and clinically relevant comorbidity in heart failure, associated with reduced functional capacity, higher symptom burden, and increased hospitalisation risk. Most evidence on iron deficiency in heart failure originates from hospital-based cohorts, whereas the epidemiology and clinical implications in primary care populations remain poorly described. This stu
BACKGROUND AND PURPOSE: The glymphatic system facilitates perivascular clearance, and its dysfunction has been implicated in neurodegenerative diseases. Diffusion tensor imaging along the perivascular space (DTI-ALPS) has been proposed as an indirect approach to assess glymphatic function, but its reliability is debated. The choice of b-value is an aspect of possible improvement. While a b-value o
Introduction: The structures of the skull and the brain are related to each other. Prior work in individuals with isolated congenital anosmia (ICA) showed that these individuals were characterized by olfactory bulb (OB) defects. The aim of this study was to compare the morphological pattern of the anterior skull base surrounding the OB between individuals with ICA and normosmic controls. We meant
Time-resolved X-ray solution scattering (TR-XSS) provides direct access to protein structural dynamics but has largely been restricted from the microsecond range up to approximately 100 milliseconds. As a result, slower enzymatic systems, including many P-type ATPases, remain difficult to probe. Here, we extend the temporal reach of TR-XSS by sequentially positioning radiation damage-free acquisit
