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Avian malaria, caused by Plasmodium parasites, commonly persists as a chronic infection, yet reliable treatment protocols remain insufficiently evaluated. Assessing treatment efficacy is essential for improving disease management and understanding impacts on host health. We conducted a 2.5-year experimental study to assess the efficacy and safety of atovaquone-proguanil (Malarone®) against Plasmod
INTRODUCTION: Fall-related injuries are a common cause of morbidity and impaired quality of life among patients with severe respiratory disease. Use of long-term oxygen therapy (LTOT) may be associated with a further increased risk.METHODS: This was a longitudinal study of patients starting LTOT between 2006 and 2023 in the Swedish DISCOVERY cohort. Rates of healthcare contact due to three types o
Introduction: Many patients do not benefit from cardiac resynchronization therapy (CRT) with current guideline parameters. The objective of this study was to examine the relationship between left ventricular activation time (LVAT) from the standard 12-lead surface electrocardiogram (ECG) and clinical outcome from CRT. Methods: A retrospective study was performed on patients receiving CRT implants
Land-use carbon metabolism (LUCM) optimization has been increasingly recognized as a critical and complex pathway toward carbon neutrality in China. Using land-use and socioeconomic data from Hubei Province (2000-2020), this study develops a dual-network framework integrating ecological network analysis (ENA) and social network analysis (SNA) to examine temporal carbon flows and spatial carbon lin
Objective: To describe arterial stiffness, ankle-brachial index (ABI), advanced glycation end products (AGE) and glycosylated hemoglobin (HbA1c) in middle-aged people with cervical and upper thoracic SCI, and compare findings with the general population. Design: Cross-sectional study with matched controls. Setting: Tertiary outpatient SCI unit in southern Sweden. Participants: Participants (n = 25
Sexual selection in simultaneous hermaphrodites can act through male–male competition and female choice, often favouring male-biased traits, yet remains understudied relative to gonochorists. We tested how sex-limited experimental evolution alters mating behaviour and the male copulatory organ (the stylet) in Macrostomum lignano. After more than 40 generations of selection for male- or female-spec
Biological strategies for manipulating light have revealed new concepts in light scattering, inspiring the design of sustainable photonic materials. While iridescent optical systems have been extensively studied, many applications require noniridescent structural colors which are much more difficult to achieve. Photonic glasses, comprising randomly arranged dielectric spheres, offer a promising so
Nitrogen availability is thought to be a key factor that modifies the strength and direction of plant-soil feedback (PSF), but how nitrogen availability and PSF interact in forests remains unresolved. For example, PSF is one of the drivers underpinning the well-known nursing effect in the Atlantic forests of the UK and Ireland. In these systems, the nursing effect occurs when Scots pine ( Pinus sy
We show the following hardness results for monotone learning and approximation of monotone circuit size: 1. Under the Randomised Exponential-Time Hypothesis (rETH), it requires time nΩ(log n) to PAC-learn monotone formulas with n input bits and size s(n) = n by monotone circuits of size n(log n)1−ϵ, for every ϵ > 0. 2. Under the Randomised Exponential-Time Hypothesis (rETH), for any δ > 0, there i
Objective: Suture-mediated closure devices have enabled totally percutaneous endovascular aneurysm repair (EVAR). Although hemorrhagic access-site complications are well recognized, closure-device related common femoral artery (CFA) stenosis or dissection is less well described. We report the use of an endovascular bailout strategy for these complications and assess midterm outcomes. Methods: Betw
Through Arctic amplification, global climate change is projected to disproportionally affect high-latitude environments. Additionally, the geographical heterogeneity and complex terrain of mountains promote climate-driven ecological change on fine spatial scales. We used a high-resolution convection-permitting regional climate model (HCLIM) and a state-of-the-art dynamic vegetation model (LPJ-GUES
Public debate is central to most theories of democracy, yet few cross-national studies have examined its association with democratic satisfaction. This article identifies three features of national public spheres – pluralism, information, and respect – and presents annual measures of these features for 175 countries from 2000 to 2020. Among electoral democracies, pluralism remained stable, but the
The Telychian Age (Llandovery, Silurian) is marked by significant radiation among marine organisms, a faunal turnover, and palaeoenvironmental changes, collectively known as the Valgu Bioevent (Valgu BE), Valgu Carbon Isotope Excursion (Valgu CIE), and the Valgu Oxygen Isotope Excursion (Valgu OIE). However, the environmental drivers of these changes remain debated. Here we investigate the middle
