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Extracellular contractile injection systems (eCISs) are phage-derived nanomachines used by bacteria to deliver effectors into target cells. Well-studied examples include the Photorhabdus asymbiotica virulence cassettes and the antifeeding prophage from Serratia entomophila, which have been engineered for heterologous cargo delivery. Recent genomic analyses identified previously uncharacterized eCI
BACKGROUND: Pediatric cancer diagnosis and treatment reduce Health-Related Quality of Life (HRQoL). The Pediatric Quality of Life (PedsQL) Cancer Module is the most commonly used cancer specific HRQoL instrument, but most studies included relatively small cohorts and no reference scores are available. The development of a PedsQL Cancer Module benchmark, based on a large population of pediatric can
We study an information design problem to reduce congestion in transportation networks. In presence of an uncertain network state, the central planner may sends private signals to the users, with the goal of steering the user equilibrium towards the system optimum flow. We consider private signals and provide sufficient conditions under which optimality may be achieved by information provision in
We deal with a control problem for a complex social network in which each agent has an action and an opinion, evolving according to a coevolutionary model. In particular, we consider a scenario in which a committed minority - a set of stubborn nodes - aims to steer a population, initially at a consensus, to a different consensus state. Our study focuses on determining the conditions under which su
The interactions between aerosols and clouds are still one of the largest sources of uncertainty in quantifying anthropogenic radiative forcing. To reduce this uncertainty, we must first determine the baseline natural aerosol loading for different environments. In the pristine and hardly accessible polar regions, the exact nature of local aerosol sources remains poorly understood. It is unclear ho
Here we reassess available evidence for the long-held misconception of amoebae possessing exceptionally large genomes. Traditionally, estimates relied on inaccurate methods like DNA weight measurements, leading to inflated sizes. These methods failed to account for contaminating DNA from prey, endosymbionts, and intrinsic genomic features like ribosomal operon amplification. Modern sequencing tech
Continuity of care represents a concept of paramount importance in territorial healthcare and notably in general practice. It is a concept focused on three main dimensions, namely informational, relational, and managerial continuity. It may impact on outcomes of older patients and older frail patients, even in patients pertaining to the surgery setting. An Italian model and a French model for cont
Competitive pressure is an important driving factor of corporate behavioural changes. Yet, it is still unclear how it influences corporate attitudes towards environmental challenges. In this study, we systematically analyse the sustainability behaviour of a global sample of publicly traded firms to examine if and how competitive pressure pushes them to implement effective behavioural changes to re
Sweden did not follow the same route that most other European countries embarked on in the handling of the COVID-19 pandemic. When other countries closed as a response to the spread of the virus, Sweden decided not to impose a full lockdown. Rather, Sweden kept a large part of society open, such as keeping schools for children and bars and restaurants open, albeit with some restrictions. The focus
This research monograph explores new frontiers in Markov chains. Although time-homogeneous Markov chains are well understood, this is not at all the case with time-inhomogeneous ones. The book, after a review on the classical theory of homogeneous chains, including the electrical network approach, introduces several new models which involve inhomogeneous chains as well as related new types of rand
Concert with National Arts Centre Orchestra, CanadaConductor: John Storgårds Programme:Joseph Haydn: Konzert für Trompete und Orchester Es-Dur Hob. VIIe:1 Betsy Jolas: Onze Lieder (1977) für Trompete und OrchesterPeter I. Tschaikowsky: Symphonie Nr. 5 e-Moll op. 64
Swedish trumpeter Håkan Hardenberger is the soloist in Rolf Wallin’s trumpet concerto Fisher King. Dima Slobodeniouk also conducts the evocative Moonlight on Jupiter by Väinö Raitio and Sergei Prokofiev's Symphony No. 7.
Venues:Wilminktheater en Muziekcentrum Enschede / Tivoli Vredenburg / Het Concertgebouw Amsterdam / Elbphilharmonie / Festhalle Viersen / Alte Oper Frankfurt / Amare / Muziekgebouw aan't IJ Amsterdam AmsterdamProgramme:Georg Philipp Telemann: Konzert für Violine, Violoncello, Trompete und Streicher in D-Dur, TWV 53:D5Ludwig van Beethoven: Streichquartett Nr. 15 a-Moll op. 132, "Heiliger Dankgesang
Ouvertyren till operetten Candide, Anders Eliassons fjärde symfoni och Beethovens Kejsarkonsert är stycken som vitt skiljer sig från varandra på pappret, men som på något märkligt sätt passar ihop. Det här programmet är livfullt, festligt och bedövande vackert.Håkan Hardenberger har besökt MSO tidigare i höst för att spela Daniel Börtz Trumpetkonsert, men denna kväll dirigerar han
Background: Long-term survival after lung transplantation is significantly shorter compared with other solid organ transplantations. Chronic lung allograft dysfunction (CLAD), including bronchiolitis obliterans syndrome (BOS), remains the major barrier to survival. CLAD is diagnosed according to ISHLT's guidelines: a 20% drop in FEV1 using spirometry for CLAD grade 1. Given the difficulties of con
Bokhandlaren och boråsprofilen John Wold (1863-1942) efterlämnade vid sin död ett värdefullt bibliotek som förvaras hos ordenssällskapet Tempel Riddare Orden i Borås. Innehållet domineras av Wolds två stora intressen: nykterhetsfrågan och ordensväsende. I boken presenteras boksamlingen med ambitionen att i stora drag belysa både dess innehåll och det historiska sammanhang den tillkommit i.
Håkan Hardenberger joins Fulcrum Point New Music Project Artistic Director Stephen Burns, CSO Principal Trumpeter Esteban Batallán, Lyric Opera’s Rebecca Oliverio with DePaul Faculty member Paul Lowry in a program of dazzling trumpet solos, duos, trios, quartets, and Trumpet Ensembles. Programme:Tōru Takemitsu: Paths in Memoriam W. Lutoslawski (Trompete solo),Plaza (Midwest Premiere) Stefano Scoda
Håkan Hardenberger performs Tomasi’s Trumpet Concerto, an expressive and technical piece that was once declared “unplayable.” Schmitt’s most famous composition—the symphonic suite from the ballet La Tragédie de Salomé—and Stravinsky’s ballet and orchestral work The Firebird, with its story of good versus evil, will come to life under the dynamic stylings of conductor Fabien Gabel.Program to Includ
Forskning visar att läkemedelsreklam kan vara vilseledande. Därför borde Läkartidningen göra som sin danska systertidning: tacka nej till industrins annonser.
