Filtyp
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, with limited systemic therapeutic options and high recurrence rates. New treatment modalities in oncology, including antibody-drug conjugates and CAR-T cells, target the tumor cell surfaceome. However, despite extensive genomic and transcriptomic profiling, actionable surface antigens for targeted immunothe
Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) plaque deposition, tau pathology, and neuroinflammation, with genetic variants in the apolipoprotein E (APOE) gene representing the strongest risk factor for late-onset AD. Microglia, the brain’s resident immune cells, are increasingly recognized as central to disease progression through their roles in neuroinflammation and Aβ clearance.
Since the discovery of graphene in 2004, there has been intense and continuous research into the possibilities of creating other 2 dimensional (2D) materials. Since then, much progress has been made, resulting in many new metals, semiconductors, and insulators that can fill any number of roles from transistors to solar cells. In this thesis, I discuss hexagonal beryllium oxide (h-BeO) as a potenti
This study aims to explore how healthcare counselors in adult psychiatry in Region Skåne work with children as next of kin and the limitations and opportunities they experience in implementing a child’s perspective. The study is based on six semi-structured interviews with healthcare counselors. The material was analyzed thematically with an inductive approach. The results indicate that healthcare
The dissertation De argutis imaginibus was presented in 1725, in Uppsala, Sweden, by supervisor Lars Arrhenius and respondent Johannes J. Dalenius. The text contains various ideas regarding emblem studies, and concerns itself with emblems as well as other argutae imagines – “witful images”. This thesis aims to present an overview of the content of the dissertation, and to frame this with a cultura
We observe that, while predicting returns remain difficult and uncertain, volatility exhibit more persistence and predictability due to well-known patterns such as volatility clustering (Mandelbrot, 1967). We test whether short-horizon volatility forecasts can be used to time leverage in a passive index strategy so as to mitigate the growth penalty from volatility drag in leveraged exchange-traded
Pollinators such as Bombus terrestris play a vital role in ecosystem stability and agricultural productivity. Developing methods to estimate key biological traits such as age and weight is crucial for advancing ecological understanding and conservation efforts. In eusocial insects like B. terrestris, age and weight influence behaviour, task allocation, and survivability, but traditional methods fo
Adeno-associated viruses (AAVs) are among the most promising vectors for safe and effective gene delivery in therapeutic applications. However, engineering functional AAV capsids remains a major challenge due to the vast sequence space, unpredictable biological performance, and limited translational success of many variants. Machine learning offers a powerful strategy to address these limitations
This thesis examines if the European Patent Convention (EPC) supports or impedes the patentability of green chemistry innovations in pharmaceuticals.. The research is motivated by the growing urgency to align intellectual property systems with environmental objectives under EU law. Using the doctrinal analysis, it evaluates how the European Patent Office (EPO) interprets the EPC’s core requirement
AIM: We investigate if merged gridded satellite rainfall products (CHIRPS, MSWEP, or SUPER), used with the HYPE hydrological model, can replace limited rain gauge measurements when modelling streamflow in poorly gauged basins. Three research questions frame this aim: (1) How does the HYPE hydrological model perform in a poorly gauged basin? (2) Which rainfall product performs better (CHIRPS, MSWEP
Polyolefins make up the majority of all plastics produced and can be found in a range of applications. Simultaneously, 60% of all plastics are not being recycled, and consequently are accumulating in the environment where it poses serious threats to both the environment, human health, and economies. Current attempts to address the problem have had limited success. An emerging solution is biodegrad
Infective endocarditis (IE) is a severe disease affecting the inner lining of the heart. Its diverse symptoms complicate diagnosis and the current main diagnostic tool is the Duke criteria which classifies suspected cases as definite, possible or rejected IE. A substantial portion of cases falls into the ambiguous “possible” category and there is a need for a more precise diagnostic system. This t
Mindfulness har under de senaste åren blivit allt mer populärt i Sverige. Från att främst ha använts inom psykologin för att hantera stress och ohälsa, har det idag spridit sig till arbetsplatser och blivit en del av olika institutioner. I den här uppsatsen undersöks mindfulness ur ett sociologiskt perspektiv: hur praktiken påverkar människors värderingar, identiteter och föreställningar om sig sjMindfulness has increasingly become a popularized phenomenon in Sweden. From being integrated at workplaces and used for therapeutic purposes in psychology, the phenomenon has been institutionalized. This study is a sociological inquiry on mindfulness-related practices and how it shapes values, identities, and beliefs. Using the lens of Pierre Bourdieu’s relational sociology and the methodology of
ODIN (Optical and Diffraction Imaging with Neutrons) is a general purpose imaging in- strument under construction at the European Spallation Source (ESS). The instrument will provide the scientific community with a wide array of neutron imaging techniques, including neutron tomography. Coupled with an integrated X-ray source, the instrument will feature multi-modal capabilities. The complementary
This thesis investigates the integration of artificial intelligence (AI ) within the Swedish courts, with a particular focus on its compatibility with the rights to privacy and a fair trial as enshrined in the Charter of Fundamental Right of the European Union (CFR). As we entered the third decade of the 21st century, a technological revolution, led by AI is transforming various sectors, including
Sex hormones play an important role in shaping immune responses, which in turn influence reproductive outcomes. The molecular and cellular mechanisms underlying the crosstalk between the immune system, sex hormones, and the reproductive system remain poorly understood. This study addressed this knowledge gap by utilizing single-cell RNA sequencing and proteome analysis to enhance the understanding
Denna kandidatuppsats undersöker ”avförtrollning som upplysningens program” utifrån Max Horkheimer och Theodor W. Adornos tes (1944), med fokus på hur detta kommer till uttryck i den ångermanländske prästen Jöns Hornæus Sannfärdig berättelse (1740/1771). Genom en kvalitativ diskursanalys, kompletterad med en enklare kvantitativ kartläggning, analyseras Hornæus framställningar av övernaturliga väseThis bachelor’s thesis examines “disenchantment as the program of Enlightenment” through Max Horkheimer and Theodor W. Adorno’s thesis (1944), focusing on how it appears in the Swedish (Ångermanland) priest Jöns Hornæus’ Sannfärdig berättelse (1740/1771). Using qualitative discourse analysis, supported by a simple quantitative survey, the study analyzes Hornæus’ depictions of supernatural beings a
Due to their representation of the Western myth, Native Americans, and women, Laura Ingalls Wilder’s semiautobiographical Little House novels have been a topic of debate since their publication between 1932 and 1971. However, scholars have overlooked the role the domestic education of girls plays in Wilder’s novels. The domestic education can be seen as a method for conveying myths of the Western
The food processing industry is integral to modern society, with increasing demands for efficiency and sustainability. Industrial food freezers, such as the JBT Marel’s GyroCompact spiral freezer, are energy-intensive systems operating for extended durations daily, making energy efficiency improvements critical both economically and environmentally. This thesis aims to develop a vision-based monit
In times of rising inflation, global unrest and shifting societal values, much of the public and academic focus has been on how economically vulnerable groups adapt their consumption. However, less attention has been paid to high-income earners who are often assumed to remain unaffected by economic fluctuations. This thesis investigates how high-income individuals in Sweden navigate their everyday
