Malaria är en av vår nutids största globala hälsoproblem och skördar hundratusentals människoliv årligen. Malaria är en parasitisk sjukdom, där Plasmodium falciparum är den gängse malariaparasiten. Denna parasit infekterar vanligen den afrikanska malariamyggan, Anopheles gambiae, som i sin tur har en hög preferens för just oss människor. Således sker spridningen av malaria till människor primärt gMalaria is a global health issue affecting hundreds of millions of people worldwide and accounts for as much as 405 000 deaths annually. Preventative actions are taken but are seemingly not enough to eradicate the spread. Targeting underlying molecular mechanisms behind the host-seeking behavior of the principal malaria vector Anopheles gambiae, would offer a new approach in the development of an

Vattenkanaler kallade akvaporiner finns i kroppen för att transportera vatten och därmed reguleras vattennivån i cellerna i kroppen. Denna process kallas trafficking vilket förenklat betyder att akvaporinen förflyttas och blir aktiverad eller avaktiverad för att öka eller minska flödet av vatten. Om denna process inte fungerar på ett korrekt sätt, kan diverse sjukdomar uppstå som orsakar problem för peWater is a large part of life on earth and is also a large part of the human body which is why it is so important. Aquaporins are water channels that transports water through a process called trafficking. Aquaporin 2 is one of these aquaporins and with a faulty trafficking or mutations it could lead to nephrogenic diabetes insipidus and severe dehydration. Ezrin is a protein in the body which FERM

The EU was initially created as an area of free trade amongst its Member States, its main objective is the realization of the full integration of the internal market. Of central importance to the objective is the fundamental freedoms and thereby the free movement of goods. However, in recent decades issues of an environmental nature have become more prevalent within the EU legal order and a framew

Detta examensarbete ger ett förslag på en ny järnvägsstation i Kirunas nya centrum. I Kiruna pågår just nu en stadsomvandling, där en tredjedel av staden flyttas tre kilometer österut på grund av markdeformationer från Kirunagruvan. Detta innebär stora förändringar för Kirunaborna men även stora förändringar i stadsbilden, då majoriteten av centrum har eller kommer rivas och byggas upp igen i nya This thesis gives a suggestion for a new railway station in the new city center of Kiruna, Sweden. Kiruna is now experiencing an urban transformation, where one third of the population and the city moves three kilometers to the east due to ground deformations coming from the Kiruna iron ore mine. This leads to huge changes for Kiruna’s population, but also huge changes in the cityscape, since most

Christian slaves and their view on the others A comparative analysis of European captivity narratives in Northern Africa during the eighteenth century In the 18 th century, several hundred thousand Europeans were captives in Northern Africa. They represented different nationalities and religions. During the same period, there were numerous conflicts based on religion, and the balance of power be

En ny underfamilj av cellulära vakter i växter Heterologt överuttryck av proteiner innebär att en gen som kodar för ett protein uttrycks i en annan värdorganism som normalt inte har den genen i sin arvsmassa. Inom biokemisk forskning är detta en viktig metod för att kunna studera proteiners struktur och funktion. Tyvärr kan uttrycket av en främmande gen medföra skador på värdorganismens celluläraHeterologous overexpression of proteins signifies that the encoding gene of a protein in one organism is expressed in another host organism that normally does not have that gene in its genome. In basic biochemical research, this is an important method for studying various protein functions such as activity and interactions in biological processes, as well as obtaining sufficient amounts to determi

With the rapid production of sportswear and its price advantage, consumption has also increased significantly, which has a rather negative impact on the environment, society, and the economy. Fashion retailers and their consumers are also well aware of this, and their demands for sustainable fashion have had a strong impact on the production of sportswear and consumer behaviour in recent years. Su

Recent years have seen digitalisation entangled in everyday life; with the broader context of a digitalised world, one can no longer see the digitalised retail space and its technological artefacts as a lone-standing phenomena. Instead, it is necessary to see digitalisation as way of understanding and being in the modern world. This paper explores the practices and subsequent meanings in the use o

I ett hållbart samhälle är tillgänglighet en viktig förutsättning för alla, oavsett deras bakgrund. Det finns olika komponenter som ingår inom begreppet tillgänglighet. En av dessa komponenter handlar om transportmöjligheten, att man ska ha möjlighet att transportera sig till olika punkter med minsta möjliga reseuppoffring. Detta kan uppnås med hjälp av kollektivtrafiken, eftersom kollektivtrafik In a sustainable society accessibility is vital and should be provided for everyone, regardless of their background. There are different components within accessibility as a concept. One of these components is transport, which has to do with the ability to transport to different destinations with minimum sacrifice. This can be achieved with public transport, because it’s available for everyone and

The purpose of this report is to investigate a branch and bound algorithm designed to construct monotone smoothing splines. The splines are defined as the solution of a minimization problem, where one wants to find a curve with non-negative derivative everywhere, that fits a data set consisting of points in the plane, while also being sufficiently smooth. The report describes the theory necessary

The common carotid artery (CCA), the artery that supplies our brains with oxygen, is of great importance in stroke research. The usual way to monitor the artery is by using ultrasound (US) imaging. An automated way of segmenting out the arteries from the US images is desired to optimize research. With an upswing in development of convolutional neural networks (CNN), this is now possible. CNN uses

Tidigare forskning visar att distansstudier vid högskolor och universitet har blivit allt vanligare. Den tidigare forskningen visar även att denna form av studier är vanligare hos individer från ett arbetarklasshem samt hos individer med föräldrar/vårdnadshavare som saknar högre studier. Syftet med denna studie var att utöka kunskapen kring distansstudier som en möjlighet till social rörlighet.

Vi lever idag i ett digitalt samhälle. Du använder förmodligen själv dagligen olika program och även om all mjukvara i slutändan består av ettor och nollor finns det allt som oftast en person bakom varje program som tagit fram den, en utvecklare. Programmerare tar ofta hjälp från så kallade mjukvaruplattformar. Dessa riktar sig inte direkt mot vanliga användare, utan mot just utvecklare av mjukvaThis research report was carried out in collaboration with Qlik AB and aimed to identify what aspects are needed from a software platform in order for developers to want to use them. It also aimed to identify how well the software platform Qlik Core had implemented these aspects. The research used online questionnaires, interviews and data analysis using Qlik Sense. The research compared how diffe

It has for long been known that dark matter must exist in our universe. Despite massive efforts to detect dark matter, its constituents remain a mystery. One strategy to unveil this mystery is to produce dark matter by colliding Standard Model particles. The most common signature of dark matter production is an excess of missing transverse energy, MET. Such an event would be very rare, which is wh