The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö. The group is focused on the complement system in health and disease. Our ambition is to make high quality basic science based on clinically relevant questions and yielding novel diagnostic approaches and clinical interventions. Our research is su

https://www.protein-chemistry.lu.se/anna-blom-research-group-0 - 2025-05-01

The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö.  The group is focused on the complement system in health and disease. The complement, crucial part of innate immune system is involved in many basic biological processes such as defence against infections but when activated in a wrong place or no

https://www.protein-chemistry.lu.se/protein-chemistry-research-group - 2025-05-01

Best publications from our group over past years. The Library in Dublin. King B.C., Kulak K, Krus U., Rosberg R., Golec E., Wozniak K., Gomez M.F., Zhange E., O'Connell D., Renström E. and Blom A.M. (2019) Complement C3 proteinst against autophagy related beta-cell detah via ATG16L1 interaction and regulation of autophagy.., Cell Metabolism, 29, 202-210. Holmquist E., Bartoschek M., Reitsma B., Ja

https://www.protein-chemistry.lu.se/top-publications - 2025-05-01

List of selected publications from our research group exemplifying the projects we are conducting. The group in Madrid at Complement Worshop Blom. A. M., Pertoft H. and Fries E. (1995) Inter-a-inhibitor is required for the formation of the hyaluronan-containing coat on fibroblasts and mesothelial cells. J. Biol. Chem., 270, 9698-9701. Blom A. M., Mörgelin M., Öyen M., Jarvet J. and Fries E. (1999)

https://www.protein-chemistry.lu.se/top-publications/selected-publications-group - 2025-05-01

In blood, complement proteins are a major component and perhaps therefore most of these were identified already decades ago. However, only in recent years it has become apparent that complement not only plays a major role in innate defense against pathogens but also identifies foreign materials and removes waste (immune complexes and dying cells). The physiological relevance of complement is demon

https://www.protein-chemistry.lu.se/projects - 2025-05-01

We are studying an unexpected role of complement – in the physiology and metabolism of pancreatic beta-cells. Surprisingly, this is related to intracellular functions of complement and therefore changes the way we perceive this “blood” system and will likely inspire discovery of many other intracellular effects of complement. We study the role of intracellular complement factor C3 and membrane bou

https://www.protein-chemistry.lu.se/projects/insulin-and-immunity-when-complement-takes-control - 2025-05-01

As a first line of defense against pathogens and a mediator between innate and adaptive immunity, complement is a particular focus of evasion strategies developed by pathogens.  We showed that one common strategy is to bind complement inhibitor C4BP, which leads to decreased opsonisation of bacteria with C3b impairing phagocytosis and allowing bacterial survival. It appears that binding of C4BP is

https://www.protein-chemistry.lu.se/projects/bacterial-complement-evasion-strategies - 2025-05-01

  Myriam Martin, Rebecca Trattner and Anna Blom Misguided or excessive complement activation is involved in many common diseases such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis and age-related macula degeneration. In collaboration with clinicians we are studying molecular mechanisms of complement involvement in these diseases. Joint inflammation in rheumatoid arthritis (RA),

https://www.protein-chemistry.lu.se/projects/pathologic-complement-activation-diseases - 2025-05-01

Expression of COMP in breast cancer tissue Complement-dependent cytotoxicity is one of the mechanisms by which therapeutic monoclonal antibodies are toxic to cancer cells. Also, complement is currently undergoing re-appreciation of its role in the immune surveillance of tumors. The majority of human tumors are low immunogenic and complement may be involved in their recognition via direct “danger s

https://www.protein-chemistry.lu.se/projects/complement-and-cancer - 2025-05-01

Complement has recently gained substantial worldwide attention, as it was discovered that several common diseases such as age-related macular degeneration (blindness in elderly) are related to deregulation of the balance between complement activation and inhibition. Full complement deficiencies lead to severe infectious and autoimmune diseases but are uncommon while it appears that we are just beg

https://www.protein-chemistry.lu.se/projects/inherited-deficiencies-complement-inhibitors - 2025-05-01

Myriam Martin, Rebecca Trattner and Anna Blom  You can reach us by mailor by calling 040-33 78 30 and 040-33 15 20Vaishnavi Dandavate, postdoctoral fellowE-mail: vaishnavi [dot] dandavate [at] med [dot] lu [dot] sePia Ecke, undergraduate studentE-mail: Pia [dot] Ecke [at] med [dot] lu [dot] seAlexander Ekström, PhD studentE-mail: alexander [dot] ekstrom [at] med [dot] lu [dot] se (alexander[dot]ek

https://www.protein-chemistry.lu.se/members-our-research-group - 2025-05-01

Here you can find description of open positions and internships in our research group. MSc StudentsWe often can offer thesis projects for Masters students within the projects conducted in our group. Please, contact Anna Blom (Anna [dot] Blom [at] med [dot] lu [dot] se (Anna[dot]Blom[at]med[dot]lu[dot]se)) directly for more details.PhD StudentsWe are always interested in reviewing PhD students appl

https://www.protein-chemistry.lu.se/open-positions - 2025-05-01

Research funding supporting projects conducted in our research group: Swedish Research Council Cancerfonden Torsten Söderberg Foundation ALF Knut and Alice Wallenberg Foundation Novo nordisk fonden Erling-Persson Family Foundation Alfred Österlund Foundation  Grants for clinical research from Skåne University Hospital (including cancer) King Gustav Vth, 80-years Anniversary Foundation Diabetesfond

https://www.protein-chemistry.lu.se/research-funding - 2025-05-01

Medical Protein Chemistry Group. Who are we? Professor Anna Blom leads the Medical Protein Chemistry group Projects conducted in our research group Open positions Lund University Diabetes Centre Department of Translational Medicine

https://www.protein-chemistry.lu.se/protein-chemistry - 2025-05-01

The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö. The group is focused on the complement system in health and disease. Our ambition is to make high quality basic science based on clinically relevant questions and yielding novel diagnostic approaches and clinical interventions. Our research is su

https://www.protein-chemistry.lu.se/anna-blom-research-group - 2025-05-01

You will find the accessible journals on the Library's basement level. In the list they are marked with "in the Library". Shortcuts to the journals A B C D E F H I J K L M N O P Q R S T V,W X Z Use the keyboard shortcut Ctrl + F (for Windows) or ⌘ + F (for Mac) to search the page.Detailed information and conventions in the list of journalsAActa physica polonicaContinued as: Acta Physica Polonica A

https://www.science-library.lu.se/search-and-find/articles-and-journals/journals-physics - 2025-05-01

The Library of Science has several subject guides and resources to help you study or do research. About our subject guidesThe Library of Science subject guides are a good place to start when looking for material such as subject databases, journals, or e-books. The guides can also help you develop your information literacy, writing, and reference management.Shortcuts to the contentGeneral guidesBio

https://www.science-library.lu.se/search-and-find/subject-and-resource-guides - 2025-05-01

The teaching materials you produce are public records and therefore must be deposited in long-term safekeeping or deleted. For advice and help, contact your department director of studies or the Faculty Archivist. Teaching materials which must be deposited Certain materials and documents produced when teaching or supervising students must be archived: Your teaching materials, compendiums, lab inst

https://www.science-library.lu.se/lecturer/records-management-teaching-materials - 2025-05-01

In 200 years, it could be your study that provides the answers. Preserving your research work, is not just about leaving an impression, as the research you are conducting today could prove invaluable for future researchers. Below, you can read about the research documentation that is to be preserved and what is to be disposed of or weeded out. Research documents that must be preserved Discuss the

https://www.science-library.lu.se/researcher-or-doctoral-student/preservation-your-research-work - 2025-05-01

Before you collect data, it is important to plan how to name and organise your files, how to describe your data (which metadata to collect), and which file formats are the appropriate ones to use.Also, consider whether you need any permits, for example from the Swedish Chemicals Agency or the Swedish Radiation Safety Authority. You may also need a permit if you are studying endangered species, tak

https://www.science-library.lu.se/researcher-or-doctoral-student/research-data-management/collection-and-description-research-data - 2025-05-01