Keeping up the PICUP
The aggregation of α-synuclein into fibrils has been long proven to be closely related to the toxicity leading to Parkinson’s disease. In this process, medium-sized intermediates called oligomers are formed, a heterogeneous group of aggregates formed by a small number of monomers. While fibrils have been proven to cause little to no toxicity, oligomers have been demonstrated to induce cell death.