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The chaperone DNAJB6b delays amyloid formation by suppressing the nucleation of amyloid fibrils and increases the solubility of amyloid-prone proteins. These dual effects on kinetics and equilibrium are related to the unusually high chemical potential of DNAJB6b in solution. As a consequence, the chaperone alone forms highly polydisperse oligomers, whereas in a mixture with an amyloid-forming prot
A method for modelling the prompt production of molecular states using the hadronic rescattering framework of the general-purpose Pythia event generator is introduced. Production cross sections of possible exotic hadronic molecules via hadronic rescattering at the LHC are calculated for the χc1(3872) resonance, a possible tetraquark state, as well as three possible pentaquark states, Pc+(4312), Pc
The Pythia event generator is used in several contexts to study hadron and lepton interactions, notably p p and p p ¯ collisions. In this article we extend the hadronic modelling to encompass the collision of a wide range of hadrons h with either a proton or a neutron, or with a simplified model of nuclear matter. To this end we model hp total and partial cross sections as a function of energy, an
Path integration is a general mechanism used by many animals to maintain an updated record of their position in relation to a set reference point.1–11 To do this, they continually integrate direction and distance information into a memorized home vector. What remains unclear is how this vector is stored, maintained, and utilized for successful navigation. A recent computational model based on the
The widespread salinisation of freshwater ecosystems poses a major threat to the biodiversity, functioning, and services that they provide. Human activities promote freshwater salinisation through multiple drivers (e.g., agriculture, resource extraction, urbanisation) that are amplified by climate change. Due to its complexity, we are still far from fully understanding the ecological and evolution
In seasonally variable environments, phenotypic plasticity in phenology may be critical for adaptation to fluctuating environmental conditions. Using an 18-generation longitudinal dataset from natural damselfly populations, we show that phenology has strongly advanced. Individual fitness data suggest this is likely an adaptive response towards a temperature-dependent optimum. A laboratory experime
In ecological sciences, animal diets are often simplified to ‘resources' or ‘caloric quantities'. However, in the present study, we investigated the optimal foraging strategy of Atlantic cod Gadus morhua when both macro- and micro-nutritional requirements are accounted for. Proteins cannot be synthesized from fatty acids, so the proteins for gonad development must come from other dietary sources.
Spontaneous magnetic alignment is the simplest known directional response to the geomagnetic field that animals perform. Magnetic alignment is not a goal directed response and its relevance in the context of orientation and navigation has received little attention. Migratory songbirds, long-standing model organisms for studying magnetosensation, have recently been reported to align their body with
CONTEXT.—: Perinatal death is an increasingly important problem as the COVID-19 pandemic continues, but the mechanism of death has been unclear.OBJECTIVE.—: To evaluate the role of the placenta in causing stillbirth and neonatal death following maternal infection with COVID-19 and confirmed placental positivity for SARS-CoV-2.DESIGN.—: Case-based retrospective clinico-pathological analysis by a mu
Background and Problem: Existing healthcare systems have been put under immense pressure during the COVID-19 pandemic. Disruptions in essential maternal and newborn services have come from even high-income countries within the World Health Organization (WHO) European Region. Aim: To describe the quality of care during pregnancy and childbirth, as reported by the women themselves, during the COVID-
Co-occurring anxiety in children on the autism spectrum is associated with greater social challenges, including poorer social skills and relationships, which may influence the severity and presentation of anxiety symptoms, particularly social anxiety. The current study used Bayesian network analytics (Williams & Mulder, 2020) and a multimethod approach to examine (a) how different facets of so
We previously reported that loss of mitochondrial transcription factor B1 (TFB1M) leads to mitochondrial dysfunction and is involved in the pathogenesis of type 2 diabetes (T2D). Whether defects in ribosomal processing impact mitochondrial function and could play a pathogenetic role in β-cells and T2D is not known. To this end, we explored expression and the functional role of dimethyladenosine tr
