BACKGROUND: Breast cancer in young adults has been implicated with a worse outcome. Analyses of genomic traits associated with age have been heterogenous, likely because of an incomplete accounting for underlying molecular subtypes. We aimed to resolve whether triple-negative breast cancer (TNBC) in younger versus older patients represent similar or different molecular diseases in the context of g

The past decade has witnessed the opening of a yawning chasm between scholarly attempts to theorise European union and the political realities of the EU (European Union) in crisis. The decade that has witnessed the ascendency of political systems analysis, neoliberal assumptions of efficiency and Europeanisation studies within Europe has also seen the failure of intergovernmental attempts to refor

The article argues that dissident voices which attempt to theorise Europe differently and advocate another European trajectory have been largely excluded and left unheard in mainstream discussions over the past decade of scholarship and analysis. Dissident voices in European Union studies are those that seek to actively challenge the mainstream of the study of Europe. The article briefly examines

Awakening interest in anion exchange membrane fuel cells (AEMFC) for low temperature applications has led to an increased demand for high-performing polymers stable under alkaline conditions. In this study a poly(p-terphenylene piperidinium)-based (PAP) membrane and ionomer was synthesised and applied in membrane electrode assemblies (MEAs), with porous gas-diffusion electrodes based on Pt catalys

The awarding of the Nobel Peace Prize 2012 to the EU (European Union) came as a surprise. Not only was the eurozone economic crisis undermining both policy effectiveness and public support for the EU, but it was also seriously challenging the EU's image in global politics. The eurozone crisis, the Nobel Prize and the search for a ‘new narrative for Europe’ demonstrate that the processes of Europea

Dalby församling inlämnade i augusti 2018 till länsstyrelsen i Skåne en ansökan om tillstånd till invändig renovering av Dalby kyrka innefattande en flytt av dopfunten från nuvarande plats på ett podium längst bak i långhuset till en plats i koret, strax till höger om predikstolen. Länsstyrelsen beviljade flytten 2018-10-10 på, som jag menar, felaktiga grunder. Jag insände därför ett överklagande

We present a unifying theory to explain cancer recurrence, therapeutic resistance, and lethality. The basis of this theory is the formation of simultaneously polyploid and aneuploid cancer cells, polyaneuploid cancer cells (PACCs), that avoid the toxic effects of systemic therapy by entering a state of cell cycle arrest. The theory is independent of which of the classically associated oncogenic mu

Color vision has evolved multiple times in both vertebrates and invertebrates and is largely determined by the number and variation in spectral sensitivities of distinct opsin subclasses. However, because of the difficulty of expressing long-wavelength (LW) invertebrate opsins in vitro, our understanding of the molecular basis of functional shifts in opsin spectral sensitivities has been biased to

Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are struc-turally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross– sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556

The efficacy and side effects of endocrine therapy in breast cancer (BC) depend largely on estrogen receptor alpha (ERα) expression, the specific drug administered, and treatment scheduling. Although the benefits of endocrine therapy outweigh any adverse effects in the initial stages of BC, later- or advanced-stage tumors acquire resistance to treatments. The mechanisms underlying tumor resistance

Amongst the impacts of climate change, those arising from extreme hydrological events are expected to cause the greatest impacts. To assess the changes in temperature and precipitation and their impacts on the discharge in the upper Yangtze Basin from pre-industrial to the end of 21st century, four hydrological models were integrated with four global climate models. Results indicated that mean dis

Demarketing is generally recognized as that aspect of marketing that aims at discouraging customers in general or a certain class of customers in particular on either a temporary or permanent basis and has been increasingly posited as a potential tool to degrow tourism and improve its overall sustainability, particularly as a result of so-called overtourism. The paper provides an overview of the v

Fertility preservation for male childhood cancer survivors not yet capable of producing mature spermatozoa, relies on experimental approaches such as testicular explant culture. Although the first steps in somatic maturation can be observed in human testicular explant cultures, germ cell depletion is a common obstacle. Hence, understanding the spermatogonial stem cell (SSC) niche environment and i

Supported lipid bilayers (SLBs) are one of the most common cell-membrane model systems to study cell-cell interactions. Nickel-chelating lipids are frequently used to functionalize the SLB with polyhistidine-tagged ligands. We show here that these lipids by themselves can induce calcium signaling in T cells, also when having protein ligands on the SLB. This is important to avoid “false” signaling