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Background. During the translation of mRNA into polypeptide, elongation factor G (EF-G) catalyzes the translocation of peptidyl-tRNA from the A site to the P site of the ribosome. According to the 'classical' model, EF-G in the GTP-bound form promotes translocation, while hydrolysis of the bound GTP promotes dissociation of the factor from the post-translocation ribosome. According to a more recen

After peptide release by a class-1 release factor, the ribosomal subunits must be recycled back to initiation. We have demonstrated that the distance between a strong Shine-Dalgarno (SD) sequence and a codon in the P site is crucial for the binding stability of the deacylated tRNA in the P site of the posttermination ribosome and the in-frame maintenance of its mRNA. We show that the elongation fa

RNA polymerases differ functionally and structurally in the initiation phase of transcription, when polymerization of 8-12 nucleotides occurs, from the later phases of transcription. Here we argue that the ribosome also might have different properties when translating the first codons in open reading frames, as compared with the later phases of translation.

#108. Entrelacé, for four vibraphonists on one vibraphone

Mesenchymal stem cells (MSCs) were proposed as a critical therapeutic candidate in diabetic nephropathy (DN). Renal stem cells as a source for repairing are controversial. The purpose of the present study was to evaluate the effect of kidney rat stem cells on DN. After evaluation of surface stem cell markers by flow cytometry analysis, MSCs that were labeled with CM-Dil were injected to experiment

Introduction: Mesenchymal stem cells (MSCs) were proposed as a critical therapeutic candidate in diabetic nephropathy (DN). Renal stem cells as a source for repairing are controversial. The purpose of the present study was to evaluate the effect of kidney rat stem cells on DN. Materials and methods: After separation of renal stem cells from rat kidney, the surface Stem cell markers were assessed b

This conceptual paper addresses how the emergent impact agenda is slowly but surely changing the normative framework of modern science. In order to understand such a cultural shift, we draw a chronology around the evaluation regime of research impact and identify a causal mechanism that changes the disciplinary structure of the research ecosystem. We draw upon a sociological model of scientific kn

Type 2 diabetes is a serious, lifestyle-related condition characterized by insufficient glycemic control resulting in hyperglycemia. Long-term hyperglycemia is a major risk factor for a range of health complications, and type 2 diabetes complications are among the leading causes of morbidity and mortality worldwide. Of all forms of diabetes, type 2 diabetes constitutes around 90% of cases, indicat

New decentralized energy-generation technologies have turned economies of scale upside down while becoming more economically viable. At the same time, the increased penetration of information technologies has led to new opportunities to manage infrastructure in a less hierarchical, more flexible way. Together with citizen demands for control over energy, these two converging trends has put energy

Internal positivity offers a computationally cheap certificate for external (inputoutput) positivity of a linear time-invariant system. However, the drawback with this certificate lies in its realization dependency. First, computing such a realization requires finding a polyhedral cone with a potentially high number of extremal generators that lifts the dimension of the state-space representation,

There have been a few reports of successful lung transplantation (LTx) in patients with SARS-CoV-2-induced acute respiratory distress syndrome (ARDS); however, all reports were with rather short follow-up. Here we present a 62-year-old man without prior lung diseases. Following SARS-CoV-2-induced ARDS and 6 months of extracorporeal membrane oxygenation, he underwent LTx. 3 months post-transplantat

Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but insights into its underlying biological mechanisms and treatments to preserve it are limited. Here we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in about 200,000 women of European ancestry. These common alleles were associated