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The genetic background of lupus nephritis (LN) has not been completely elucidated. We performed a case-only study of 2886 SLE patients, including 947 (33%) with LN. Renal biopsies were available from 396 patients. The discovery cohort (Sweden, n = 1091) and replication cohort 1 (US, n = 962) were genotyped on the Immunochip and replication cohort 2 (Denmark/Norway, n = 833) on a custom array. Pati
Dupuytren’s disease (DD) is a fibroproliferative disorder affecting the palmar fascia of the hand. Risk factors include diabetes mellitus (DM), whereas a high body mass index (BMI) is associated with a lower prevalence of DD. The aim of this study was to further elucidate risk and protective factors for the development of DD using longitudinal population-based data from the Malmö Diet and Cancer S
The dissertation aims to advance our understanding about the role of local industry structure in regional economic development. More specifically, it investigates how relatedness between local industries (i.e. similarities in what kind of knowledge industries use) contributes to and constrains regional economic development. Empirically, the dissertation investigates Swedish regional development in
Premise of research. Geochemical fingerprinting of fossil plants is a relatively new research field complementing morphological analyses and providing information for paleoenvironmental interpretations. Ginkgoales contains a single extant species but was diverse through the Mesozoic and is an excellent target for biochemical analyses. Methodology. Cuticles derived from fresh and fallen autumn leav
Live blogging from legal trials has become one of the most accessible ways in which the public can gain direct insight into legal proceedings, particularly in countries where television cameras are denied entry into the courtroom. Whilst live blogging constitutes an important way of ensuring the transparency and openness of legal processes and documents – a principle known as open justice and a ke
The cultivation of ethnographic discovery is not only about being insightful in the field by paying attention to unexpected events and unforeseen social processes. We should also search for potentially surprising or disturbing findings after the fieldwork. This can provide additional ways to create an original and sustainable understanding of research material. In this chapter, we discuss a study
Human midbrain dopamine (DA) neurons are a heterogeneous group of cells that share a common neurotransmitter phenotype and are in close anatomical proximity but display different functions, sensitivity to degeneration, and axonal innervation targets. The A9 DA neuron subtype controls motor function and is primarily degenerated in Parkinson's disease (PD), whereas A10 neurons are largely unaffected
Recent advances in cell reprogramming have made it possible to form new therapeutic cells within the body itself via a process called direct conversion or lineage reprogramming. A series of studies have shown that it is possible to reprogram resident glia into new neurons within the brain parenchyma. These studies opened up for the targeted attempts to achieve functional brain repair using in vivo
The use of stem cell derived dopamine neurons for treating patients with Parkinson's disease has now evolved to the first in human clinical trials. In this debate, we argue that assuming these trials give positive outcomes that this therapy will supercede DBS as the neurosurgical treatment of choice for PD patients in the future given it is a one-off therapy that repairs a critical pathway in the
In two recent postmortem studies, Jeffrey Kordower and colleagues report new findings that open up for an interesting discussion on the status of GDNF/NRTN signaling in patients with Parkinson's disease (PD), adding an interesting perspective on the, admittedly very limited, signs of restorative effects previously seen in GDNF/NRTN-treated patients. Their new findings show that the level of the GD
We study acoustic streaming in liquids driven by a nondissipative acoustic body force created by light-induced temperature gradients. This thermoacoustic streaming produces a velocity amplitude nearly 100 times higher than the boundary-driven Rayleigh streaming and the Rayleigh-Bénard convection at a temperature gradient of 10 K/mm in the channel. The Rayleigh streaming is altered by the acoustic
The Jk(a-b-) phenotype results from alterations in the JK gene and is characterized by absence of the RBC urea transporter in the cell membrane. The frequency of Jk(a-b-) varies among populations, but this phenotype is most commonly found in people of Polynesian and Finnish descent. Although rare, Jk(a-b-) individuals present a clinical challenge because anti-Jk3 is produced readily in response to
According to non-doxasticism, religious faith can be in an important sense belief-less. However, such faith becomes vulnerable to the despair-problem known from the literature on hope. I suggest that the problem can be overcome by adopting J. L. Schellenberg’s imagination-based account of non-doxastic faith. In developing this idea, I draw on the account of imagination offered by Amy Kind and an u
All the cells of the individuals with phenotypes "p" y "Pk" lack the glucidic antigens of "public" blood groups. These subjects form natural and regular antibodies against the missing structures (anti-P, anti-PP1 y anti-PP1Pk) that agglutínate or hemolyze the red-blood cells of every individual, excepting those with the same phenotype. Due to the exceptional character of these pictures (a few indi
