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The maturation process that occurs in most viruses is evolutionarily driven as it resolves several conflicting virion assembly requirements. During herpesvirus assembly in a host cell nucleus, micron-long double-stranded herpes DNA is packaged into a nanometer-sized procapsid. This leads to strong confinement of the viral genome with resulting tens of atmospheres of intra-capsid DNA pressure. Yet,
The mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute lymphoblastic leukemia (ALL) are not fully understood. We performed whole genome sequencing of samples collected at diagnosis, relapse(s) and remission from 29 Nordic patients. Somatic point mutations and large-scale structural variants were called using individually matched remission samples as controls, and all
Participant representativeness and statistical power are crucial elements of robust research with human participants, both of which relate to the successful recruitment of research participants. Nevertheless, such core features may often not be fully reported or duly considered in psychiatric research. Building on our experiences of collecting data in the context of forensic mental health services
Omräkning av barns (≥2 år) kreatininvärden till motsvarande värden vid 18 års ålder och applicerade i Lund–Malmö-formeln för vuxna ledde till avsevärt förbättrad skattning av GFR bland barn vid uppmätt GFR <75, bibehållen noggrannhet ≥75 ml/min/1,73m2 och likvärdig med pediatriska formler.Lund–Malmö-formeln kan användas under hela livet ≥2 år utan plötsliga artificiella förändringar i skattad GFR Age-adjustment of creatinine, i.e. recalculation of childhood levels of creatinine to corresponding levels at 18 years of age and applied in the adult revised Lund-Malmö GFR equation led to markedly improved accuracy in Swedish children (n=1 718) at measured GFR <75 mL/min/1.73 m2 (n=318) and preserved high accuracy at ≥75 mL/min/1.73 m2 (n=1 400). The adjusted LMR equation performed as well as de
Aim: According to the Cognitive Model of Insomnia, engaging in sleep-related cognitive processes may lead to sleep problems over time. The aim was to examine associations between five sleep-related cognitive processes and the incidence of insomnia, and to investigate if baseline anxiety and depression influence the associations. Methods: Two thousand three hundred and thirty-three participants com
In the present work, the impact of phosphorus impurities on the grain boundary strength of nickel has been investigated by means of density functional theory (DFT) modelling. Owing to different outcomes and trends previously reported in the literature, it is unclear whether P is strengthening or weakening the Ni grain boundary. To address this issue, we utilize three different DFT based methods: t
China’s unprecedented measures to mobilize its diverse surveillance apparatus played a key part in the country’s successful containment of the ongoing coronavirus pandemic. Critics worldwide believe these invasive technologies, in the hands of an authoritarian regime, could trample the right to privacy and curb fundamental civil and human rights. However, there is little domestic public resistance
There have been recently multiple calls to investigate the rhythmic behaviors (RBs) of nonhuman animals, as a way to gain insight into the evolution of human rhythm cognition and musicality. Currently, the empirical data from non-human species is scarce. Most strikingly, we lack data from chimpanzees (Pan troglodytes), our closest genetic relatives. Here, we present an observational study conducte
Bus priority measures are introduced in cities in order to improve travel time, frequency, and reliability, thereby benefiting the passengers and establishing a more attractive and competitive public transport system. Since first being implemented in Chicago in the late 1930s, bus priority measures are now widely applied across the globe, and a plethora of measures regarding priority in terms of t
We propose that an interdisciplinary approach is necessary to better understand the normative gender aspects of automating perinatal depression-care in socially assistive robots and how to take them into account at design stage. Consequently, the aim is twofold: firstly, to understand the existing normative gender aspects within perinatal depression, and secondly, to enable the socially assistive
Purpose: According to the World Health Organization (WHO), hearing loss (HL) affects up to 15% of the world’s adult population. Coping and personality are hypothesized to underlie quality of life (QoL) and distress scores. We aimed to study the importance of personality and coping in persons with HL for self-reported hearing disability, QoL, and distress. Methods: A cross-sectional survey was carr
BACKGROUND: Opioids are still widely prescribed to long-term pain patients although they are no longer recommended for long-term treatments due to poor evidence for long-term efficacy, risks of serious side effects, and the possibility of inducing opioid hyperalgesia. In a Cochrane study from 2017, the authors identified an urgent need for more randomized controlled trials investigating the effici
Previous studies have shown an association between IQ and adaptive global functioning, i.e. how well a person is functioning in different domains of life. However, it is unclear to what extent such an association applies in children with neurodevelopmental disorders (NDDs). The study group consisted of 550 population-screened children assessed with the K-SADS, WISC-IV, and the C-GAS. Approximately
A circular concept involving use of faba bean hulls for production of oyster mushrooms (Pleurotus ostreatus (Jacq.) P. Kumm.) and the post-harvest residues for feed purposes was evaluated. Faba bean hulls are a waste remaining after the beans are dehulled to decrease the content of anti-nutritional factors and increase the food value of the beans. Faba bean hulls proved very suitable as substrate
West African Sahelian and Sudanian ecosystems provide essential services to people and also play a significant role within the global carbon cycle. However, climate and land use are dynamically changing, and uncertainty remains with respect to how these changes will affect the potential of these regions to provide food and fodder resources or how they will affect the biosphere-atmosphere exchange
This policy brief looks into the role of social norms to fight corruption in the school system in the Cau Giay district in Hanoi. An ongoing research project has conducted multiple ethnographic field studies in schools and included parents, teachers, and other school personnel in the research data. Their experiences and reflections are the core of this brief. The results show the existence of info
