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Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles (SV) and released at the synaptic active zone (AZ). While in recent years major progress has been made in unraveling the molecular machinery responsible for SV docking, fusion and exocytosis, the mechanisms governing AZ protein and SV trafficking through axons still remain unclear. Here, we performed stop-f
Copper chalcogenide nanocrystals find applications in photovoltaic inks, bio labels, and thermoelectric materials. We reveal insights in the nucleation and growth during synthesis of anisotropic Cu2ZnSnS4 nanocrystals by simultaneously performing in situ X-ray absorption spectroscopy (XAS) and small-angle X-ray scattering (SAXS). Real-time XAFS reveals that upon thiol injection into the reaction f
This thesis consists of three self-contained papers in theoretical and computational macroeconomics and growth theory with income inequality and human capital accumulation as common themes. The first paper investigates what level of income tax progressivity is welfare-optimal given modern patterns of income inequality in the US. The paper develops a model for endogenous income inequality that fits
Context. Gaia Early Data Release 3 (Gaia EDR3) provides accurate astrometry for about 1.6 million compact (QSO-like) extragalactic sources, 1.2 million of which have the best-quality five-parameter astrometric solutions. Aims. The proper motions of QSO-like sources are used to reveal a systematic pattern due to the acceleration of the solar systembarycentre with respect to the rest frame of the Un
Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that in recent years has been reported to have significant effects on numerous tissues. Chronic obstructive pulmonary disease (COPD) is associated with hypophosphatemia but the evidence for elevated plasma levels of FGF23 in COPD subjects is ambiguous. Recently, FGF23 has even been shown to be involved in the inflammatory pathways activ
Background: Individuals from melanoma-prone families have similar or reduced sun-protective behaviors compared to the general population. Studies on trends in sun-related behaviors have been temporally and geographically limited. Methods: Individuals from an international consortium of melanoma-prone families (GenoMEL) were retrospectively asked about sunscreen use, sun exposure (time spent outsid
Even though floral scent is of major importance for pollinator attraction, it is less investigated than other floral traits. Previous studies suggest the importance of joint exploration of olfactory and visual floral cues to understand plant–pollinator interactions. We investigated flower scents in Collinsia heterophylla, a bee-pollinated, annual herb a with mixed-mating system combining self- and
Cryogels are interconnected macroporous materials that are synthesized from a monomer solution at sub-zero temperatures. Cryogels, which are used in various applications in many research areas, are frequently used in biomedicine applications due to their excellent properties, such as biocompatibility, physical resistance and sensitivity. Cryogels can also be prepared in powder, column, bead, spher
Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked to adverse pulmonary effects. However, the impact of low-level environmental PAH exposure on lung function in early adulthood remains uncertain. Objectives: To evaluate the associations between urinary PAH metabolites and lung function parameters in young adults. Methods: Urinary metabolites of pyrene, phenanthrene, an
Patients in Opioid Substitution Treatment (OST) have increased mortality and morbidity, with circulatory conditions suggested to be a contributing factor. Since OST patients tend to have unmet physical healthcare needs, a small-scale intervention providing on-site primary healthcare (PHC) in OST clinics was implemented in Malmö, Sweden in 2016. In this study, we assessed registered circulatory con
In this chapter, we explore how natural resources can be exploitable resources thanks to knowledge improvements. This issue is tackled by looking at the evolution of engineering faculties and graduate engineers from 1850 to 1939 in Andean and Nordic countries, two regions where natural resources were critical at the onset of modern economic growth. We find the consolidation of a knowledge gap betw
This chapter represents a comparative study of the emergence of environmental policies in the Chilean and Swedish copper industry. The chapter identifies a number of key factors which helps to explain dissimilar characteristics of actions to protect the environment in both countries as well as the timing for these actions. One key difference identified—besides obvious factors such as income levels
Pseudo-guaianolides represent a large group of sesquiterpene lactones exhibiting significant cytotoxic and anti-inflammatory activities. Their biological activities are due to a 훼-methylene-훾-lactone unit in their chemical structure, which reacts with free sulfhydryl groups of free cysteine via a Michael-addition. Damsin is a major pseudo guaianolide found in Ambrosia arborescens Mill., a plant di
Purpose – The aim of this paper is to contribute with increased knowledge of the complex role of internal communication during a crisis like the COVID-19 pandemic. More specifically, the authors want to address the following research questions. How can the overall approach to internal crisis communication during the pandemic be interpreted, and what view of internal crisis communication does this
In this thesis we study the steady Euler equations in three dimensions where the solution is assumed to have nonvanishing vorticity. The thesis is based on three research papers. In the first and the third we study the steady Euler equations in the context of the water wave problem, which means we are solving a free boundary problem, while in the second paper we study the equations in a fixed cyli
A new error metric targeting rendered high dynamic range images is presented. Our method computes a composite visualization over a number of low dynamic range error maps of exposure compensated and tone mapped image pairs with automatically computed, or manually provided, parameters. We argue that our new error maps predict errors substantially better than metrics previously used in rendering. Sou
Den 28:e oktober slog Amazon.se upp dörrarna för den svenska e-handelsplatsen och experternas åsikter var delade. Amazon fick kritik för att det var ett hastverk med dåliga översättningar och att svenskarna inte skulle attraheras. I en liknande rapport som denna från december månad såg konsumenternas reaktion positiv ut (Anselmsson & Tunca, 2020). Hur ser situationen ut efter att Black Friday
