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The detection of electromagnetic (EM) emission following the gravitational wave (GW) event GW170817 opened the era of multi-messenger astronomy with GWs and provided the first direct evidence that at least a fraction of binary neutron star (BNS) mergers are progenitors of short Gamma-Ray Bursts (GRBs). GRBs are also expected to emit very-high energy (VHE, > 100 GeV) photons, as proven by the recen
The Cherenkov Telescope Array (CTA) observatory is the next generation of ground-based imaging atmospheric Cherenkov telescopes (IACTs). Building on the strengths of current IACTs, CTA is designed to achieve an order of magnitude improvement in sensitivity, with unprecedented angular and energy resolution. CTA will also increase the energy reach of IACTs, observing photons in the energy range from
Background: Intermittent claudication requires treatment with secondary prevention to reduce disease progression and the risk of cardiovascular events and to improve quality of life. Health literacy and self-efficacy are important preconditions for the health behaviour changes necessary for adhering to secondary prevention. Aim: Evaluate health literacy in patients with intermittent claudication r
High-energy gamma rays are promising tools to constrain or reveal the nature of dark matter, in particular Weakly Interacting Massive Particles. Being well into its pre-construction phase, the Cherenkov Telescope Array (CTA) will soon probe the sky in the 20 GeV - 300 TeV energy range. Thanks to its improved energy and angular resolutions as well as significantly larger effective area when compare
The Cherenkov Telescope Array (CTA) is the next-generation gamma-ray observatory currently under construction. It will improve over the current generation of imaging atmospheric Cherenkov telescopes (IACTs) by a factor of five to ten in sensitivity and it will be able to observe the whole sky from a combination of two sites: a northern site in La Palma, Spain, and a southern one in Paranal, Chile.
High levels of cell-free haemoglobin (Hb) may occur in plasma as a consequence of e.g., pathological haemolysis or blood transfusion. These Hb molecules can be removed from blood circulation by forming a complex with the acute-phase protein haptoglobin (Hp) and thereby can also the intrinsic toxicity of free Hb be limited. In this study it is shown that ferric HbA, HbF, HbE and HbS, respectively,
The Cherenkov Telescope Array (CTA) is the future ground-based observatory for gamma-ray astronomy at very high energies. The atmosphere is an integral part of every Cherenkov telescope. Different atmospheric conditions, such as clouds, can reduce the fraction of Cherenkov photons produced in air showers that reach ground-based telescopes, which may affect the performance. Decreased sensitivity of
Background and ObjectivesImpaired spatial navigation is considered an early sign in many neurodegenerative diseases. We aimed to determine whether spatial navigation was associated with future dementia in patients with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) and to explore associations between spatial navigation and biomarkers of Alzheimer disease (AD) and neurodegene
We investigate the possibility of detection of the VHE gamma-ray counterparts to the neutrino astrophysical sources within the Neutrino Target of Opportunity (NToO) program of CTA using the populations simulated by the FIRESONG software to resemble the diffuse astrophysical neutrino flux measured by IceCube. We derive the detection probability for different zenith angles and geomagnetic field conf
In this Letter, we explore the use of thermodynamic length to improve the performance of experimental protocols. In particular, we implement Landauer erasure on a driven electron level in a semiconductor quantum dot, and compare the standard protocol in which the energy is increased linearly in time with the one coming from geometric optimization. The latter is obtained by choosing a suitable metr
The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). A decision analytic model was constructed to estimate the costs and benefits of one-off screening strategies differentiated by screening age, sex and the threshold for initiating statin therapy (“uniform” or “age-adjusted”) from the Spanish NHS perspective. The age-adjusted
Swedish universities and colleges have received a substantial funding increase since the turn of the millennium, as part of continued policies of expanding the admission of students to higher education to broader layers of the population and strengthen Swedish public research and development to increase the competitiveness of the Swedish knowledge-based economy. In this article, publicly available
Introduction: As people with haemophilia (PWH) receive better treatment and live longer they are more likely to encounter cardiovascular disease (CVD) and other comorbidities. ESC guidelines for the acute management of patients presenting with acute coronary syndrome (ACS) are based on the non-haemophilia population. Aim: To review the guidelines and propose relevant adaptations for PWHA without i
Several types of Galactic sources, like magnetars, microquasars, novae or pulsar wind nebulae flares, display transient emission in the X-ray band. Some of these sources have also shown emission at MeV-GeV energies. However, none of these Galactic transients have ever been detected in the very-high-energy (VHE; E>100 GeV) regime by any Imaging Air Cherenkov Telescope (IACT). The Galactic Transient
The relative importance of adaptation and individual ontogenetic experience in dogs’ high levels of behavioral compatibility with humans has been a topic of intense scientific attention over the past two decades. Salomons et al. Current Biology, 31, 3137–3144, (2021) recently presented a particularly rich data set of observations on both wolf and dog puppies that has the potential to contribute su
Objective: The decline in suicide rates has leveled off in many countries during the last decade, suggesting that new interventions are needed in the work with suicide prevention. Learnings from investigations of suicide should contribute to the development of these new interventions. However, reviews of investigations have indicated that few new lessons have been learned. To be an effective tool,
At very high energies (VHE), the emission of γ rays is dominated by discrete sources. Due to the limited resolution and sensitivity of current-generation instruments, only a small fraction of the total Galactic population of VHE γ-ray sources has been detected significantly. The larger part of the population can be expected to contribute as a diffuse signal alongside emission originating from prop
We consider the calculations of photoionization spectra and core resonances of open-shell systems using range-separated time-dependent density-functional theory. Specifically, we use the time-dependent range-separated hybrid (TDRSH) scheme, combining a long-range Hartree-Fock exchange potential and kernel with a short-range potential and kernel from a local density-functional approximation, and th
PURPOSE: We constructed Bladder Cancer Data Base Sweden (BladderBaSe) 2.0 to expand studies in BladderBaSe on incidence, treatment outcomes, side effects, survival and health economic aspects of men and women with cancer in the urinary bladder, upper tract urothelial carcinoma (UTUC) (renal pelvis and ureter) and urethral carcinoma. PARTICIPANTS: BladderBaSe 2.0 includes 53 298 patients with cance
Mantle cell lymphoma (MCL) after relapse is associated with poor prognosis. No standard of care exists and available evidence for treatments is limited, particularly in patients who fail Bruton tyrosine kinase inhibitor (BTKi) therapy. This multicentre retrospective chart review study, SCHOLAR-2, addresses this knowledge gap and reports on data collected from 240 patients with relapsed/refractory
