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BACKGROUND: The critical role of the immune system in controlling cancer progression has become evident and immune modulatory therapy is now approved for clinical use. However, while the majority of studies on the inflammatory tumour microenvironment have focused on the cellular immune response, in particular the prognostic and predictive role of various T cell infiltrates, the role of the humoral
OBJECTIVES: In Sweden, two centres perform lung transplantation for a population of about 9 million and the entire population is covered for lung transplantation by government health insurance. Lund University Hospital is one of these centres. This retrospective report reviews the 25-year experience of the Skåne University Hospital Lung Transplant Program with particular emphasis on short-term out
BACKGROUND: Chronic obstructive pulmonary disease is a leading cause of mortality, and associated with increased healthcare utilization and healthcare expenditure. In several countries, morbidity-based systems have changed the way resources are allocated in general practice. In primary care, fee-for-services tariffs are often based on political negotiation rather than costing systems. The potentia
This article accounts for recent developments in corporate social responsibility, international trade and investment law, international human rights law, development aid, and the laws of home states reaching extraterritorially in order to advance a regulatory perspective on commerce and human rights. While these developments are remarkable, the analysis documents the prevalence of softer strategie
Steam explosion pretreatments was used to improve the anaerobic biodegradability of Miscanthus lutarioriparius (M. lutarioriparius). The pretreatments were carried out under five different conditions: L1 (0.5 MPa 153°C 5 min), L2 (1.0 MPa 180°C 5 min), L3 (1.5 MPa 198°C 3 min), L4 (1.5 MPa 198°C 5 min) and L5 (1.5 MPa 198°C 10 min). The biochemical methane potential (BMP) of raw M. lutarioriparius
This paper addresses the challenge of how to understand and handle divergent views on the need for leadership interventions between managers and subordinates. Recent popular discourses of leadership, such as the authentic leadership perspective, privileges the potential leader himself or herself as the origin of leadership. This perspective thereby neglects the view of the followers and the essent
AIM: To evaluate correlations between physical activity, VO2PEAK and body fat versus autonomic function in children.METHODS: Children (n = 98) between 10 and 12 years underwent a maximal exercise test (VO2PEAK) and dual-energy X-ray absorptiometry measured body fat. General physical activity, moderate to vigorous physical activity and vigorous physical activity were assessed by accelerometers. Dee
In recent years, there has been an upsurge of pan-European institutions, both from within the European Union and outside it, aiming to support European cinema. This article questions what it means to be a ‘European film institution’ in the contemporary film industry at a time when economic, political and cultural turmoil in the wake of the financial crisis affects this identity. The institution st
Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation in animal models, and elimination of this cell population is required for curative therapies. Here, we describe a series of pooled, in vivo RNAi screens to identify essential transcription factors (TFs) in a murine model of acute myeloid leukemia (AML) with genetically and phenotypically de
OBJECTIVE: The aim of this study was to analyze whether the associations between perceived environmental and individual characteristics and perceived walking limitations in older people differ between those with intact and those with poorer lower extremity performance.METHOD: Persons aged 75 to 90 (N= 834) participated in interviews and performance tests in their homes. Standard questionnaires wer
The increasing importance being placed on waste prevention in Swedish wastegovernance raises the question of how waste prevention is defined in practice.This paper presents a qualitative analysis of a sample of fifty-one key Swedishwaste prevention initiatives with the purpose of identifying which kind ofactions are imagined, promoted, and set into motion under the label of wasteprevention. The an
In this paper I study the public debt dynamics of three episodes (the crises of the 1950s, the 1980s and 2010-15) in Ireland’s modern economic history. By using traditional debt dynamic decomposition formulae, I measure the components which contributed most to public debt ratio reduction following previous high debt episodes. I also employ the case of Sweden for comparative purposes, in how it eme
BACKGROUND: There is no consensus whether angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) should be used for secondary prevention in all or in only high-risk patients after an acute myocardial infarction (AMI).OBJECTIVES: This study sought to investigate whether ACEI/ARB treatment after AMI is associated with better outcomes across different risk profiles, inc
